Human Gene PPP1CB (ENST00000395366.3_5) from GENCODE V47lift37
  Description: protein phosphatase 1 catalytic subunit beta, transcript variant 1 (from RefSeq NM_002709.3)
Gencode Transcript: ENST00000395366.3_5
Gencode Gene: ENSG00000213639.11_13
Transcript (Including UTRs)
   Position: hg19 chr2:28,974,696-29,025,806 Size: 51,111 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr2:28,974,991-29,022,169 Size: 47,179 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:28,974,696-29,025,806)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPP1CB
Diseases sorted by gene-association score: noonan syndrome-like disorder with loose anagen hair 2* (900), noonan syndrome 1 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.37 RPKM in Artery - Tibial
Total median expression: 846.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.00295-0.451 Picture PostScript Text
3' UTR -775.603637-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Descriptions from all associated GenBank mRNAs
  AF092905 - Homo sapiens protein phosphatase type-1 catalytic subunit delta isoform (PPCS1D) mRNA, complete cds.
AK303682 - Homo sapiens cDNA FLJ58972 complete cds, highly similar to Serine/threonine-protein phosphatase PP1-beta catalytic subunit (EC 3.1.3.16).
AK295957 - Homo sapiens cDNA FLJ58189 complete cds, highly similar to Serine/threonine-protein phosphatase PP1-beta catalytic subunit (EC 3.1.3.16).
AK316532 - Homo sapiens cDNA, FLJ79431 complete cds, highly similar to Serine/threonine-protein phosphatase PP1-beta catalytic subunit (EC 3.1.3.16).
BX647970 - Homo sapiens mRNA; cDNA DKFZp686E2152 (from clone DKFZp686E2152).
AK312329 - Homo sapiens cDNA, FLJ92643, Homo sapiens protein phosphatase 1, catalytic subunit, beta isoform(PPP1CB), mRNA.
BX647295 - Homo sapiens mRNA; cDNA DKFZp781I1636 (from clone DKFZp781I1636).
X80910 - H.sapiens PPP1CB mRNA.
BC002697 - Homo sapiens protein phosphatase 1, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:3672 IMAGE:3609386), complete cds.
BC012045 - Homo sapiens protein phosphatase 1, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:10563 IMAGE:3631338), complete cds.
EU668339 - Homo sapiens epididymis secretory sperm binding protein Li 80p (HEL-S-80p) mRNA, complete cds.
JD458053 - Sequence 439077 from Patent EP1572962.
JD396579 - Sequence 377603 from Patent EP1572962.
AB464241 - Synthetic construct DNA, clone: pF1KB3095, Homo sapiens SPDYA gene for speedy homolog A, without stop codon, in Flexi system.
AM392772 - Synthetic construct Homo sapiens clone IMAGE:100002296 for hypothetical protein (PPP1CB gene).
CR542285 - Homo sapiens full open reading frame cDNA clone RZPDo834H1226D for gene PPP1CB, protein phosphatase 1, catalytic subunit, beta isoform; complete cds, without stopcodon.
BT019744 - Homo sapiens protein phosphatase 1, catalytic subunit, beta isoform mRNA, complete cds.
KJ904529 - Synthetic construct Homo sapiens clone ccsbBroadEn_13923 PPP1CB gene, encodes complete protein.
CR542263 - Homo sapiens full open reading frame cDNA clone RZPDo834D1126D for gene PPP1CB, protein phosphatase 1, catalytic subunit, beta isoform; complete cds, incl. stopcodon.
AK093247 - Homo sapiens cDNA FLJ35928 fis, clone TESTI2010806, highly similar to SERINE/THREONINE PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT (EC 3.1.3.16).
AX748012 - Sequence 1537 from Patent EP1308459.
JD520356 - Sequence 501380 from Patent EP1572962.
JD036778 - Sequence 17802 from Patent EP1572962.
JD364026 - Sequence 345050 from Patent EP1572962.
JD419970 - Sequence 400994 from Patent EP1572962.
JD545739 - Sequence 526763 from Patent EP1572962.
JD225978 - Sequence 207002 from Patent EP1572962.
JD022179 - Sequence 3203 from Patent EP1572962.
JD035899 - Sequence 16923 from Patent EP1572962.
JD350529 - Sequence 331553 from Patent EP1572962.
JD078763 - Sequence 59787 from Patent EP1572962.
JD518709 - Sequence 499733 from Patent EP1572962.
JD026770 - Sequence 7794 from Patent EP1572962.
JD033291 - Sequence 14315 from Patent EP1572962.
JD020840 - Sequence 1864 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000395366.1, ENST00000395366.2, HEL-S-80p , NM_002709, uc318xiw.1, uc318xiw.2, V9HW04, V9HW04_HUMAN
UCSC ID: ENST00000395366.3_5
RefSeq Accession: NM_002709.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.