ID:PPR3A_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 3A; AltName: Full=Protein phosphatase 1 glycogen-associated regulatory subunit; AltName: Full=Protein phosphatase type-1 glycogen targeting subunit; Short=RG1; FUNCTION: Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By similarity). TISSUE SPECIFICITY: Skeletal muscle and heart. DOMAIN: The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes. PTM: Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase (By similarity). DISEASE: Defects in PPP1R3A are a cause of susceptibility to noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. SIMILARITY: Contains 1 CBM21 (carbohydrate binding type-21) domain. SEQUENCE CAUTION: Sequence=AAS07492.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16821
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
