ID:2AAB_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; AltName: Full=PP2A subunit A isoform PR65-beta; AltName: Full=PP2A subunit A isoform R1-beta; FUNCTION: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGOL1. Interacts with RAF1. INTERACTION: P67775:PPP2CA; NbExp=6; IntAct=EBI-357094, EBI-712311; P63151:PPP2R2A; NbExp=2; IntAct=EBI-357094, EBI-1048931; Q15172:PPP2R5A; NbExp=2; IntAct=EBI-357094, EBI-641666; Q16537:PPP2R5E; NbExp=2; IntAct=EBI-357094, EBI-968374; P11233:RALA; NbExp=6; IntAct=EBI-357094, EBI-1036803; O08722:Unc5b (xeno); NbExp=4; IntAct=EBI-357094, EBI-4404185; DOMAIN: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure. SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family. SIMILARITY: Contains 15 HEAT repeats. SEQUENCE CAUTION: Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30154
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0060561 apoptotic process involved in morphogenesis GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
LF208486 - JP 2014500723-A/15989: Polycomb-Associated Non-Coding RNAs. LF213953 - JP 2014500723-A/21456: Polycomb-Associated Non-Coding RNAs. AK292275 - Homo sapiens cDNA FLJ76434 complete cds, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B), transcript variant 2, mRNA. AK301705 - Homo sapiens cDNA FLJ53228 complete cds, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B), transcript variant 2, mRNA. BC027596 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform, mRNA (cDNA clone MGC:26454 IMAGE:4831056), complete cds. KJ904531 - Synthetic construct Homo sapiens clone ccsbBroadEn_13925 PPP2R1B-like gene, encodes complete protein. DQ890606 - Synthetic construct clone IMAGE:100003236; FLH167782.01X; RZPDo839F0390D protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B) gene, encodes complete protein. DQ894107 - Synthetic construct Homo sapiens clone IMAGE:100008567; FLH167778.01L; RZPDo839F0389D protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B) gene, encodes complete protein. EU176538 - Synthetic construct Homo sapiens clone IMAGE:100011646; FLH264007.01L; RZPDo839D11245D protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform (PPP2R1B) gene, encodes complete protein. AF163473 - Homo sapiens protein phosphatase 2A regulatory subunit A beta isoform (PPP2R1B) mRNA, complete cds. DQ584959 - Homo sapiens piRNA piR-52071, complete sequence. JD390244 - Sequence 371268 from Patent EP1572962. JD297887 - Sequence 278911 from Patent EP1572962. JD358343 - Sequence 339367 from Patent EP1572962. JD268328 - Sequence 249352 from Patent EP1572962. JD564829 - Sequence 545853 from Patent EP1572962. JD089760 - Sequence 70784 from Patent EP1572962. JD073013 - Sequence 54037 from Patent EP1572962. JD515567 - Sequence 496591 from Patent EP1572962. JD373978 - Sequence 355002 from Patent EP1572962. JD360444 - Sequence 341468 from Patent EP1572962. JD453284 - Sequence 434308 from Patent EP1572962. JD161328 - Sequence 142352 from Patent EP1572962. JD067272 - Sequence 48296 from Patent EP1572962. JD329745 - Sequence 310769 from Patent EP1572962. JD368226 - Sequence 349250 from Patent EP1572962. JD168076 - Sequence 149100 from Patent EP1572962. JD328638 - Sequence 309662 from Patent EP1572962. JD550901 - Sequence 531925 from Patent EP1572962. JD439242 - Sequence 420266 from Patent EP1572962. JD285851 - Sequence 266875 from Patent EP1572962. JD498869 - Sequence 479893 from Patent EP1572962. JD228254 - Sequence 209278 from Patent EP1572962. JD291272 - Sequence 272296 from Patent EP1572962. JD385220 - Sequence 366244 from Patent EP1572962. JD093237 - Sequence 74261 from Patent EP1572962. JD409044 - Sequence 390068 from Patent EP1572962. JD235907 - Sequence 216931 from Patent EP1572962. JD292613 - Sequence 273637 from Patent EP1572962. JD494406 - Sequence 475430 from Patent EP1572962. LF376956 - JP 2014500723-A/184459: Polycomb-Associated Non-Coding RNAs. JD296634 - Sequence 277658 from Patent EP1572962. JD307899 - Sequence 288923 from Patent EP1572962. JD367048 - Sequence 348072 from Patent EP1572962. JD323030 - Sequence 304054 from Patent EP1572962. JD307151 - Sequence 288175 from Patent EP1572962. JD434986 - Sequence 416010 from Patent EP1572962. JD529754 - Sequence 510778 from Patent EP1572962. JD430502 - Sequence 411526 from Patent EP1572962. JD289033 - Sequence 270057 from Patent EP1572962. JD042925 - Sequence 23949 from Patent EP1572962. JD452021 - Sequence 433045 from Patent EP1572962. JD404231 - Sequence 385255 from Patent EP1572962. LF376955 - JP 2014500723-A/184458: Polycomb-Associated Non-Coding RNAs. JD501046 - Sequence 482070 from Patent EP1572962. JD369733 - Sequence 350757 from Patent EP1572962. JD315635 - Sequence 296659 from Patent EP1572962. JD531122 - Sequence 512146 from Patent EP1572962. JD324664 - Sequence 305688 from Patent EP1572962. AK293388 - Homo sapiens cDNA FLJ54667 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. JD531041 - Sequence 512065 from Patent EP1572962. M65254 - Protein phosphatase 2A 65 kDa regulatory subunit-beta mRNA, complete cds. JD350011 - Sequence 331035 from Patent EP1572962. JD509863 - Sequence 490887 from Patent EP1572962. JD235248 - Sequence 216272 from Patent EP1572962. JD220750 - Sequence 201774 from Patent EP1572962. AK294716 - Homo sapiens cDNA FLJ56507 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. JD061471 - Sequence 42495 from Patent EP1572962. JD184984 - Sequence 166008 from Patent EP1572962. JD291366 - Sequence 272390 from Patent EP1572962. AF087438 - Homo sapiens protein phosphatase 2 subunit A isoform beta (PPP2R1B) mRNA, complete cds. AK296455 - Homo sapiens cDNA FLJ55030 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. AB384965 - Synthetic construct DNA, clone: pF1KB4592, Homo sapiens PPP2R1B gene for serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform, complete cds, without stop codon, in Flexi system. LF376954 - JP 2014500723-A/184457: Polycomb-Associated Non-Coding RNAs. LF376949 - JP 2014500723-A/184452: Polycomb-Associated Non-Coding RNAs. LF376948 - JP 2014500723-A/184451: Polycomb-Associated Non-Coding RNAs. LF376946 - JP 2014500723-A/184449: Polycomb-Associated Non-Coding RNAs. LF376945 - JP 2014500723-A/184448: Polycomb-Associated Non-Coding RNAs. JD383092 - Sequence 364116 from Patent EP1572962. JD076610 - Sequence 57634 from Patent EP1572962. JD408874 - Sequence 389898 from Patent EP1572962. MA449530 - JP 2018138019-A/21456: Polycomb-Associated Non-Coding RNAs. MA444063 - JP 2018138019-A/15989: Polycomb-Associated Non-Coding RNAs. MA612533 - JP 2018138019-A/184459: Polycomb-Associated Non-Coding RNAs. MA612532 - JP 2018138019-A/184458: Polycomb-Associated Non-Coding RNAs. MA612531 - JP 2018138019-A/184457: Polycomb-Associated Non-Coding RNAs. MA612526 - JP 2018138019-A/184452: Polycomb-Associated Non-Coding RNAs. MA612525 - JP 2018138019-A/184451: Polycomb-Associated Non-Coding RNAs. MA612523 - JP 2018138019-A/184449: Polycomb-Associated Non-Coding RNAs. MA612522 - JP 2018138019-A/184448: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P30154 (Reactome details) participates in the following event(s):
R-HSA-163769 Activation of PP2A by Xylulose-5-phosphate R-HSA-195251 Assembly of the destruction complex R-HSA-389532 PP2A binds CTLA4 homodimer R-HSA-432143 PECAM-1 binds PP2A R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 R-HSA-201685 Beta-catenin is released from the destruction complex R-HSA-388833 Phosphorylation of CTLA-4 R-HSA-6811454 MAPKs phosphorylate PP2A R-HSA-6811472 IER3 recruits MAPKs to PP2A-B56-beta,gamma R-HSA-8856945 PP2A methylation by LCMT1 R-HSA-8856951 PP2A demethylation by PPME1 R-HSA-2430552 p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D R-HSA-6792871 CCNG1 recruits PP2A-PPP2R5C to MDM2 R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2 R-HSA-163689 Dephosphorylation of pChREBP (Ser 196) by PP2A R-HSA-163750 Dephosphorylation of phosphoPFKFB1 by PP2A complex R-HSA-201790 DARPP-32 is dephosphorylated on Thr75 by PP2A R-HSA-5229343 AXIN is phosphorylated in the destruction complex R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex R-HSA-195275 Phosphorylation of APC component of the destruction complex R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-388809 CTLA-4 binds B7-1/B7-2 R-HSA-195304 Association of beta-catenin with the destruction complex R-HSA-390329 Dephosphorylation of AKT by PP2A R-HSA-5672957 PP2A dephosphorylates KSR1 R-HSA-5672961 PP2A dephosphorylates inactive RAFs R-HSA-5675431 PP2A dephosphorylates RAF1 R-HSA-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma R-HSA-163688 Dephosphorylation of pChREBP (Thr 666) by PP2A R-HSA-164056 Dephosphorylation of pChREBP (Ser 568) by PP2A R-HSA-199959 ERKs are inactivated by protein phosphatase 2A R-HSA-113503 PP2A mediated localization of RB1 protein in chromatin R-HSA-1363274 Dephosphorylation of p107 (RBL1) by PP2A R-HSA-1363276 Dephosphorylation of p130 (RBL2) by PP2A R-HSA-4088141 PP2A-PPP2R2A dephosphorylates FOXM1 R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-163685 Energy Metabolism R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-389513 CTLA4 inhibitory signaling R-HSA-432142 Platelet sensitization by LDL R-HSA-5467337 APC truncation mutants have impaired AXIN binding R-HSA-5467340 AXIN missense mutants destabilize the destruction complex R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-6804757 Regulation of TP53 Degradation R-HSA-1430728 Metabolism R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors R-HSA-70171 Glycolysis R-HSA-180024 DARPP-32 events R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-195721 Signaling by WNT R-HSA-388841 Costimulation by the CD28 family R-HSA-418346 Platelet homeostasis R-HSA-4839744 truncated APC mutants destabilize the destruction complex R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-4839748 AMER1 mutants destabilize the destruction complex R-HSA-199418 Negative regulation of the PI3K/AKT network R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-5673000 RAF activation R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-198753 ERK/MAPK targets R-HSA-202670 ERKs are inactivated R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-69275 G2/M Transition R-HSA-69231 Cyclin D associated events in G1 R-HSA-68875 Mitotic Prophase R-HSA-6806003 Regulation of TP53 Expression and Degradation R-HSA-70326 Glucose metabolism R-HSA-111885 Opioid Signalling R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-162582 Signal Transduction R-HSA-1280218 Adaptive Immune System R-HSA-109582 Hemostasis R-HSA-4791275 Signaling by WNT in cancer R-HSA-1257604 PIP3 activates AKT signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-113510 E2F mediated regulation of DNA replication R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69236 G1 Phase R-HSA-5633007 Regulation of TP53 Activity R-HSA-71387 Metabolism of carbohydrates R-HSA-418594 G alpha (i) signalling events R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-168256 Immune System R-HSA-5663202 Diseases of signal transduction R-HSA-9006925 Intracellular signaling by second messengers R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-187037 Signaling by NTRK1 (TRKA) R-HSA-450294 MAP kinase activation R-HSA-69206 G1/S Transition R-HSA-453279 Mitotic G1-G1/S phases R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-388396 GPCR downstream signalling R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-5683057 MAPK family signaling cascades R-HSA-166520 Signaling by NTRKs R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-448424 Interleukin-17 signaling R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-212436 Generic Transcription Pathway R-HSA-372790 Signaling by GPCR R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-449147 Signaling by Interleukins R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-73857 RNA Polymerase II Transcription R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168249 Innate Immune System R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
