Human Gene PPP2R2C (ENST00000382599.9_7) from GENCODE V47lift37
  Description: protein phosphatase 2 regulatory subunit Bgamma, transcript variant 1 (from RefSeq NM_020416.4)
Gencode Transcript: ENST00000382599.9_7
Gencode Gene: ENSG00000074211.14_9
Transcript (Including UTRs)
   Position: hg19 chr4:6,322,308-6,474,341 Size: 152,034 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr4:6,325,029-6,473,956 Size: 148,928 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:6,322,308-6,474,341)mRNA (may differ from genome)Protein (447 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: 2ABG_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; AltName: Full=IMYPNO1; AltName: Full=PP2A subunit B isoform B55-gamma; AltName: Full=PP2A subunit B isoform PR55-gamma; AltName: Full=PP2A subunit B isoform R2-gamma; AltName: Full=PP2A subunit B isoform gamma;
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
SIMILARITY: Contains 7 WD repeats.
CAUTION: The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1 to 23).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.75 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 680.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -220.60385-0.573 Picture PostScript Text
3' UTR -870.102721-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000009 - PP2A_PR55
IPR018067 - PP2A_PR55_CS
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9Y2T4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019888 protein phosphatase regulator activity
GO:0004722 protein serine/threonine phosphatase activity

Biological Process:
GO:0000278 mitotic cell cycle
GO:0032502 developmental process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0070262 peptidyl-serine dephosphorylation

Cellular Component:
GO:0000159 protein phosphatase type 2A complex
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF383964 - JP 2014500723-A/191467: Polycomb-Associated Non-Coding RNAs.
AK296474 - Homo sapiens cDNA FLJ58008 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform.
BC032954 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform, mRNA (cDNA clone MGC:33570 IMAGE:4823280), complete cds.
AF086924 - Homo sapiens protein phosphatase 2A1 B gamma subunit IMYPNO1 mRNA, complete cds.
AF145027 - Homo sapiens protein phosphatase 2A1 B gamma subunit mRNA, complete cds.
AK316003 - Homo sapiens cDNA, FLJ78902 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform.
MA619541 - JP 2018138019-A/191467: Polycomb-Associated Non-Coding RNAs.
BC045682 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform, mRNA (cDNA clone IMAGE:5300526).
BC021735 - Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform, mRNA (cDNA clone IMAGE:4816112).
AK127386 - Homo sapiens cDNA FLJ45468 fis, clone BRSTN2015788.
JD083684 - Sequence 64708 from Patent EP1572962.
JD539993 - Sequence 521017 from Patent EP1572962.
JD560043 - Sequence 541067 from Patent EP1572962.
JD439256 - Sequence 420280 from Patent EP1572962.
JD314434 - Sequence 295458 from Patent EP1572962.
JD094518 - Sequence 75542 from Patent EP1572962.
JD447947 - Sequence 428971 from Patent EP1572962.
JD429339 - Sequence 410363 from Patent EP1572962.
JD429188 - Sequence 410212 from Patent EP1572962.
JD549348 - Sequence 530372 from Patent EP1572962.
JD302800 - Sequence 283824 from Patent EP1572962.
JD159167 - Sequence 140191 from Patent EP1572962.
JD292689 - Sequence 273713 from Patent EP1572962.
JD332907 - Sequence 313931 from Patent EP1572962.
JD437490 - Sequence 418514 from Patent EP1572962.
JD421194 - Sequence 402218 from Patent EP1572962.
JD180165 - Sequence 161189 from Patent EP1572962.
JD161180 - Sequence 142204 from Patent EP1572962.
JD407985 - Sequence 389009 from Patent EP1572962.
JD500081 - Sequence 481105 from Patent EP1572962.
JD271476 - Sequence 252500 from Patent EP1572962.
JD260555 - Sequence 241579 from Patent EP1572962.
JD490377 - Sequence 471401 from Patent EP1572962.
JD221234 - Sequence 202258 from Patent EP1572962.
JD544697 - Sequence 525721 from Patent EP1572962.
JD292673 - Sequence 273697 from Patent EP1572962.
JD161792 - Sequence 142816 from Patent EP1572962.
JD192960 - Sequence 173984 from Patent EP1572962.
JD405961 - Sequence 386985 from Patent EP1572962.
JD071662 - Sequence 52686 from Patent EP1572962.
JD137094 - Sequence 118118 from Patent EP1572962.
AK122849 - Homo sapiens cDNA FLJ16469 fis, clone BRHIP3009140, highly similar to Serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, gamma isoform.
AK093115 - Homo sapiens cDNA FLJ35796 fis, clone TESTI2005835, highly similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform.
AX747932 - Sequence 1457 from Patent EP1308459.
JD190747 - Sequence 171771 from Patent EP1572962.
JD339028 - Sequence 320052 from Patent EP1572962.
JD177863 - Sequence 158887 from Patent EP1572962.
JD532842 - Sequence 513866 from Patent EP1572962.
JD088289 - Sequence 69313 from Patent EP1572962.
JD137751 - Sequence 118775 from Patent EP1572962.
JD100214 - Sequence 81238 from Patent EP1572962.
JD447931 - Sequence 428955 from Patent EP1572962.
JD500298 - Sequence 481322 from Patent EP1572962.
JD394939 - Sequence 375963 from Patent EP1572962.
JD362240 - Sequence 343264 from Patent EP1572962.
JD362239 - Sequence 343263 from Patent EP1572962.
KJ901657 - Synthetic construct Homo sapiens clone ccsbBroadEn_11051 PPP2R2C gene, encodes complete protein.
AB590545 - Synthetic construct DNA, clone: pFN21AB8130, Homo sapiens PPP2R2C gene for protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform, without stop codon, in Flexi system.
JD309650 - Sequence 290674 from Patent EP1572962.
JD434840 - Sequence 415864 from Patent EP1572962.
CU689582 - Synthetic construct Homo sapiens gateway clone IMAGE:100019357 5' read PPP2R2C mRNA.
AB209183 - Homo sapiens mRNA for gamma isoform of regulatory subunit B55, protein phosphatase 2 isoform b variant protein.
JD287093 - Sequence 268117 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: 2ABG_HUMAN, A8MSY7, B7Z3Y1, ENST00000382599.1, ENST00000382599.2, ENST00000382599.3, ENST00000382599.4, ENST00000382599.5, ENST00000382599.6, ENST00000382599.7, ENST00000382599.8, NM_020416, Q7Z4V7, Q8NEC4, Q9H3G7, Q9Y2T4, uc318qxp.1, uc318qxp.2
UCSC ID: ENST00000382599.9_7
RefSeq Accession: NM_020416.4
Protein: Q9Y2T4 (aka 2ABG_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.