Human Gene PPP2R2D (ENST00000422256.2) from GENCODE V47lift37
  Description: protein phosphatase 2 regulatory subunit Bdelta (from HGNC PPP2R2D)
Gencode Transcript: ENST00000422256.2
Gencode Gene: ENSG00000175470.14
Transcript (Including UTRs)
   Position: hg19 chr10:133,753,533-133,770,019 Size: 16,487 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr10:133,758,825-133,769,198 Size: 10,374 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:133,753,533-133,770,019)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.53 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 428.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.50485-0.199 Picture PostScript Text
3' UTR -272.00821-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000009 - PP2A_PR55
IPR015943 - WD40/YVTN_repeat-like_dom

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63829 - Calcium-dependent phosphotriesterase
101898 - NHL repeat
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9NZ48
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019888 protein phosphatase regulator activity

Biological Process:
GO:0043666 regulation of phosphoprotein phosphatase activity

Cellular Component:
GO:0000159 protein phosphatase type 2A complex


-  Descriptions from all associated GenBank mRNAs
  AB040974 - Homo sapiens KIAA1541 mRNA for KIAA1541 protein.
AB590522 - Synthetic construct DNA, clone: pFN21AE1916, Homo sapiens PPP2R2D gene for protein phosphatase 2, regulatory subunit B, delta isoform, without stop codon, in Flexi system.
HQ447504 - Synthetic construct Homo sapiens clone IMAGE:100070841; CCSB014140_02 protein phosphatase 2, regulatory subunit B, delta isoform (PPP2R2D) gene, encodes complete protein.
KJ894269 - Synthetic construct Homo sapiens clone ccsbBroadEn_03663 PPP2R2D gene, encodes complete protein.
BC047379 - Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform, mRNA (cDNA clone MGC:51327 IMAGE:5267510), complete cds.
AK293065 - Homo sapiens cDNA FLJ77397 complete cds, highly similar to Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform (PPP2R2D), transcript variant 1, mRNA.
BC045531 - Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform, mRNA (cDNA clone IMAGE:5260389), **** WARNING: chimeric clone ****.
BC060885 - Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform, mRNA (cDNA clone IMAGE:30345158), partial cds.
AK000402 - Homo sapiens cDNA FLJ20395 fis, clone KAT00207, highly similar to 2ABA_RAT PROTEIN PHOSPHATASE PP2A.
BC072402 - Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform, mRNA (cDNA clone MGC:90289 IMAGE:6048730), complete cds.
AF220046 - Homo sapiens uncharacterized hematopoietic stem/progenitor cells protein MDS026 mRNA, complete cds.
BC058076 - Homo sapiens protein phosphatase 2, regulatory subunit B, delta isoform, mRNA (cDNA clone IMAGE:6502514), partial cds.
JD361465 - Sequence 342489 from Patent EP1572962.
JD194015 - Sequence 175039 from Patent EP1572962.
AK001483 - Homo sapiens cDNA FLJ10621 fis, clone NT2RP2005498, highly similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform.
JD056728 - Sequence 37752 from Patent EP1572962.
JD375585 - Sequence 356609 from Patent EP1572962.
JD099791 - Sequence 80815 from Patent EP1572962.
JD437613 - Sequence 418637 from Patent EP1572962.
JD179649 - Sequence 160673 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AB040974, ENST00000422256.1, Q9NZ48, Q9NZ48_HUMAN, uc319rqc.1
UCSC ID: ENST00000422256.2
RefSeq Accession: NM_018461.5
Protein: Q9NZ48

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.