ID:PPP5_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 5; Short=PP5; EC=3.1.3.16; AltName: Full=Protein phosphatase T; Short=PP-T; Short=PPT; FUNCTION: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 iron ion per subunit (By similarity). COFACTOR: Binds 1 manganese ion per subunit (By similarity). SUBUNIT: Interacts with CDC16 and CDC27. INTERACTION: Self; NbExp=2; IntAct=EBI-716663, EBI-716663; Q16543:CDC37; NbExp=2; IntAct=EBI-716663, EBI-295634; P03372:ESR1; NbExp=4; IntAct=EBI-716663, EBI-78473; Q92731:ESR2; NbExp=4; IntAct=EBI-716663, EBI-78505; P07900:HSP90AA1; NbExp=8; IntAct=EBI-716663, EBI-296047; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53041
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000278 mitotic cell cycle GO:0001933 negative regulation of protein phosphorylation GO:0006281 DNA repair GO:0006351 transcription, DNA-templated GO:0006470 protein dephosphorylation GO:0006974 cellular response to DNA damage stimulus GO:0010288 response to lead ion GO:0016576 histone dephosphorylation GO:0035970 peptidyl-threonine dephosphorylation GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043278 response to morphine GO:0051259 protein oligomerization GO:0051291 protein heterooligomerization GO:0060548 negative regulation of cell death GO:0070262 peptidyl-serine dephosphorylation GO:0070301 cellular response to hydrogen peroxide GO:0071276 cellular response to cadmium ion GO:1901215 negative regulation of neuron death GO:1904550 response to arachidonic acid GO:2000324 positive regulation of glucocorticoid receptor signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
