ID:PRG2_HUMAN DESCRIPTION: RecName: Full=Bone marrow proteoglycan; Short=BMPG; AltName: Full=Proteoglycan 2; Contains: RecName: Full=Eosinophil granule major basic protein; Short=EMBP; Short=MBP; AltName: Full=Pregnancy-associated major basic protein; Flags: Precursor; FUNCTION: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. SUBUNIT: In pregnancy serum, the proform exists as a disulfide- linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg. SUBCELLULAR LOCATION: Bone marrow proteoglycan: Secreted. Note=The proform is secreted. SUBCELLULAR LOCATION: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). TISSUE SPECIFICITY: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. DEVELOPMENTAL STAGE: Levels of the proform increase in serum and placenta during pregnancy. PTM: Nitrated. MISCELLANEOUS: Binds heparin. Does not bind calcium. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Wikipedia; Note=Major basic protein entry; URL="http://en.wikipedia.org/wiki/Major_basic_protein"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Eosinophil major basic protein; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_207";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13727
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002215 defense response to nematode GO:0002376 immune system process GO:0006955 immune response GO:0032693 negative regulation of interleukin-10 production GO:0032753 positive regulation of interleukin-4 production GO:0042035 regulation of cytokine biosynthetic process GO:0042742 defense response to bacterium GO:0043312 neutrophil degranulation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
