ID:PRG3_HUMAN DESCRIPTION: RecName: Full=Proteoglycan 3; AltName: Full=Eosinophil major basic protein homolog; AltName: Full=Prepro-major basic protein homolog; Short=Prepro-MBPH; Flags: Precursor; FUNCTION: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Localized to the eosinophil secondary granule. TISSUE SPECIFICITY: Expressed in bone marrow. Not detected in placenta. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Eosinophil major basic protein homolog; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_208";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2Y8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
