ID:KAPCB_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase catalytic subunit beta; Short=PKA C-beta; EC=2.7.11.11; FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by cAMP. SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity). INTERACTION: Q92917:GPKOW; NbExp=4; IntAct=EBI-5258763, EBI-746309; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity). TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAD92426.1; Type=Frameshift; Positions=322; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/prkacb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase PF14531 - Kinase-like
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P22694
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ891884 - Synthetic construct Homo sapiens clone ccsbBroadEn_01278 PRKACB gene, encodes complete protein. KJ897377 - Synthetic construct Homo sapiens clone ccsbBroadEn_06771 PRKACB gene, encodes complete protein. KJ905281 - Synthetic construct Homo sapiens clone ccsbBroadEn_14781 PRKACB gene, encodes complete protein. LF206366 - JP 2014500723-A/13869: Polycomb-Associated Non-Coding RNAs. BC035058 - Homo sapiens protein kinase, cAMP-dependent, catalytic, beta, mRNA (cDNA clone MGC:41879 IMAGE:5262372), complete cds. AK314550 - Homo sapiens cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA. M34181 - Human testis-specific cAMP-dependent protein kinase catalytic subunit (C-beta isoform) mRNA, complete cds. EU832783 - Synthetic construct Homo sapiens clone HAIB:100067812; DKFZo008C0233 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein. GQ129404 - Synthetic construct Homo sapiens clone HAIB:100068472; DKFZo004C0234 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds. AB451364 - Homo sapiens PRKACB mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2, partial cds, clone: FLJ08037AAAF. AB451239 - Homo sapiens PRKACB mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2, complete cds, clone: FLJ08037AAAN. BX537705 - Homo sapiens mRNA; cDNA DKFZp686H10244 (from clone DKFZp686H10244). BX641026 - Homo sapiens mRNA; cDNA DKFZp686K18247 (from clone DKFZp686K18247). AK304322 - Homo sapiens cDNA FLJ54730 complete cds, highly similar to cAMP-dependent protein kinase, beta-2-catalytic subunit (EC 2.7.11.11). EU832837 - Synthetic construct Homo sapiens clone HAIB:100067866; DKFZo008H0133 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein. GQ129233 - Synthetic construct Homo sapiens clone HAIB:100068528; DKFZo004H0134 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds. AK296482 - Homo sapiens cDNA FLJ52554 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11). AK304375 - Homo sapiens cDNA FLJ54579 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11). CR936631 - Homo sapiens mRNA; cDNA DKFZp781I2452 (from clone DKFZp781I2452). AB209189 - Homo sapiens mRNA for cAMP-dependent protein kinase catalytic subunit beta isoform 2 variant protein. AK091420 - Homo sapiens cDNA FLJ34101 fis, clone FCBBF3007631, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11). AX746972 - Sequence 497 from Patent EP1308459. EU832842 - Synthetic construct Homo sapiens clone HAIB:100067871; DKFZo008H0633 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein. GQ129248 - Synthetic construct Homo sapiens clone HAIB:100068533; DKFZo004H0634 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds. AK316115 - Homo sapiens cDNA, FLJ79014 complete cds, highly similar to cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11). MA441943 - JP 2018138019-A/13869: Polycomb-Associated Non-Coding RNAs. BC016285 - Homo sapiens protein kinase, cAMP-dependent, catalytic, beta, mRNA (cDNA clone MGC:9320 IMAGE:3916100), complete cds. CU677593 - Synthetic construct Homo sapiens gateway clone IMAGE:100018627 5' read PRKACB mRNA. AB463197 - Synthetic construct DNA, clone: pF1KB8430, Homo sapiens PRKACB gene for protein kinase, cAMP-dependent, catalytic, beta, without stop codon, in Flexi system. AM392526 - Synthetic construct Homo sapiens clone IMAGE:100002647 for hypothetical protein (PRKACB gene). AM393233 - Synthetic construct Homo sapiens clone IMAGE:100002909 for hypothetical protein (PRKACB gene). AM393317 - Synthetic construct Homo sapiens clone IMAGE:100002648 for hypothetical protein (PRKACB gene). AM393497 - Synthetic construct Homo sapiens clone IMAGE:100002649 for hypothetical protein (PRKACB gene). AY927364 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 2 (PRKACB) mRNA, partial cds, alternatively spliced. AY927365 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 3 (PRKACB) mRNA, partial cds, alternatively spliced. BX647515 - Homo sapiens mRNA; cDNA DKFZp686G17199 (from clone DKFZp686G17199). AY927366 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4 (PRKACB) mRNA, partial cds, alternatively spliced. AY927367 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4ab (PRKACB) mRNA, partial cds, alternatively spliced. AY927368 - Homo sapiens cAMP-dependent protein kinase catalytic beta subunit isoform 4abc (PRKACB) mRNA, partial cds, alternatively spliced. GQ129231 - Synthetic construct Homo sapiens clone HAIB:100068526; DKFZo004G1134 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, partial cds. EU832835 - Synthetic construct Homo sapiens clone HAIB:100067864; DKFZo008G1133 protein kinase, cAMP-dependent, catalytic, beta protein (PRKACB) gene, encodes complete protein. LF353572 - JP 2014500723-A/161075: Polycomb-Associated Non-Coding RNAs. LF353568 - JP 2014500723-A/161071: Polycomb-Associated Non-Coding RNAs. MA589149 - JP 2018138019-A/161075: Polycomb-Associated Non-Coding RNAs. MA589145 - JP 2018138019-A/161071: Polycomb-Associated Non-Coding RNAs. LF353560 - JP 2014500723-A/161063: Polycomb-Associated Non-Coding RNAs. LF353559 - JP 2014500723-A/161062: Polycomb-Associated Non-Coding RNAs. JD548472 - Sequence 529496 from Patent EP1572962. JD259982 - Sequence 241006 from Patent EP1572962. JD221129 - Sequence 202153 from Patent EP1572962. JD303589 - Sequence 284613 from Patent EP1572962. JD235464 - Sequence 216488 from Patent EP1572962. JD291822 - Sequence 272846 from Patent EP1572962. JD266656 - Sequence 247680 from Patent EP1572962. LF353558 - JP 2014500723-A/161061: Polycomb-Associated Non-Coding RNAs. JD345204 - Sequence 326228 from Patent EP1572962. JD559921 - Sequence 540945 from Patent EP1572962. JD391929 - Sequence 372953 from Patent EP1572962. JD170937 - Sequence 151961 from Patent EP1572962. LF353557 - JP 2014500723-A/161060: Polycomb-Associated Non-Coding RNAs. JD490118 - Sequence 471142 from Patent EP1572962. JD562332 - Sequence 543356 from Patent EP1572962. JD146761 - Sequence 127785 from Patent EP1572962. JD474142 - Sequence 455166 from Patent EP1572962. JD199851 - Sequence 180875 from Patent EP1572962. JD083096 - Sequence 64120 from Patent EP1572962. JD528103 - Sequence 509127 from Patent EP1572962. JD314298 - Sequence 295322 from Patent EP1572962. JD353299 - Sequence 334323 from Patent EP1572962. JD259546 - Sequence 240570 from Patent EP1572962. LF353556 - JP 2014500723-A/161059: Polycomb-Associated Non-Coding RNAs. JD509228 - Sequence 490252 from Patent EP1572962. JD242327 - Sequence 223351 from Patent EP1572962. JD433117 - Sequence 414141 from Patent EP1572962. JD288411 - Sequence 269435 from Patent EP1572962. LF353555 - JP 2014500723-A/161058: Polycomb-Associated Non-Coding RNAs. AL050208 - Homo sapiens mRNA; cDNA DKFZp586F2323 (from clone DKFZp586F2323). MA589137 - JP 2018138019-A/161063: Polycomb-Associated Non-Coding RNAs. MA589136 - JP 2018138019-A/161062: Polycomb-Associated Non-Coding RNAs. MA589135 - JP 2018138019-A/161061: Polycomb-Associated Non-Coding RNAs. MA589134 - JP 2018138019-A/161060: Polycomb-Associated Non-Coding RNAs. MA589133 - JP 2018138019-A/161059: Polycomb-Associated Non-Coding RNAs. MA589132 - JP 2018138019-A/161058: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_gpcrPathway - Signaling Pathway from G-Protein Families h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM h_mCalpainPathway - mCalpain and friends in Cell motility h_plcePathway - Phospholipase C-epsilon pathway h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_agpcrPathway - Attenuation of GPCR Signaling h_crebPathway - Transcription factor CREB and its extracellular signals h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_akapCentrosomePathway - Protein Kinase A at the Centrosome h_badPathway - Regulation of BAD phosphorylation h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_shhPathway - Sonic Hedgehog (Shh) Pathway h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_no1Pathway - Actions of Nitric Oxide in the Heart h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Reactome (by CSHL, EBI, and GO)
Protein P22694 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
