ID:KAPCG_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase catalytic subunit gamma; Short=PKA C-gamma; EC=2.7.11.11; FUNCTION: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by cAMP. SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. TISSUE SPECIFICITY: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAC41690.1; Type=Erroneous initiation; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/prkacg/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase PF14531 - Kinase-like
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P22612
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ897378 - Synthetic construct Homo sapiens clone ccsbBroadEn_06772 PRKACG gene, encodes complete protein. KJ905282 - Synthetic construct Homo sapiens clone ccsbBroadEn_14782 PRKACG gene, encodes complete protein. M34182 - Human testis-specific protein kinase gamma-subunit mRNA, complete cds. BC039888 - Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma, mRNA (cDNA clone MGC:47865 IMAGE:5165721), complete cds. JD066354 - Sequence 47378 from Patent EP1572962. JD214620 - Sequence 195644 from Patent EP1572962. JD038153 - Sequence 19177 from Patent EP1572962. JD244592 - Sequence 225616 from Patent EP1572962. JD525799 - Sequence 506823 from Patent EP1572962. JD290141 - Sequence 271165 from Patent EP1572962. JD262788 - Sequence 243812 from Patent EP1572962. JD164765 - Sequence 145789 from Patent EP1572962. JD226699 - Sequence 207723 from Patent EP1572962. JD545877 - Sequence 526901 from Patent EP1572962. JD119494 - Sequence 100518 from Patent EP1572962. JD149704 - Sequence 130728 from Patent EP1572962. JD352189 - Sequence 333213 from Patent EP1572962. JD168765 - Sequence 149789 from Patent EP1572962. JD544293 - Sequence 525317 from Patent EP1572962. JD551417 - Sequence 532441 from Patent EP1572962. JD231619 - Sequence 212643 from Patent EP1572962. JD229914 - Sequence 210938 from Patent EP1572962. DQ890764 - Synthetic construct clone IMAGE:100003394; FLH165769.01X; RZPDo839G06160D protein kinase, cAMP-dependent, catalytic, gamma (PRKACG) gene, encodes complete protein. DQ893927 - Synthetic construct Homo sapiens clone IMAGE:100008387; FLH165766.01L; RZPDo839G06159D protein kinase, cAMP-dependent, catalytic, gamma (PRKACG) gene, encodes complete protein. AB463461 - Synthetic construct DNA, clone: pF1KB6497, Homo sapiens PRKACG gene for cAMP-dependent catalytic protein kinase gamma, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_shhPathway - Sonic Hedgehog (Shh) Pathway h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_nos1Pathway - Nitric Oxide Signaling Pathway h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM h_mCalpainPathway - mCalpain and friends in Cell motility h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway h_crebPathway - Transcription factor CREB and its extracellular signals h_gpcrPathway - Signaling Pathway from G-Protein Families h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_agpcrPathway - Attenuation of GPCR Signaling h_badPathway - Regulation of BAD phosphorylation h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_no1Pathway - Actions of Nitric Oxide in the Heart h_plcePathway - Phospholipase C-epsilon pathway h_akapCentrosomePathway - Protein Kinase A at the Centrosome
Reactome (by CSHL, EBI, and GO)
Protein P22612 (Reactome details) participates in the following event(s):