ID:KAP3_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit; FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Co-localizes with PJA2 in the cytoplasm and at the cell membrane. TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. PTM: Phosphorylated by the activated catalytic chain. SIMILARITY: Belongs to the cAMP-dependent kinase regulatory chain family. SIMILARITY: Contains 2 cyclic nucleotide-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31323
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005515 protein binding GO:0008603 cAMP-dependent protein kinase regulator activity GO:0019901 protein kinase binding GO:0019904 protein domain specific binding GO:0030552 cAMP binding GO:0031625 ubiquitin protein ligase binding GO:0034236 protein kinase A catalytic subunit binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0001932 regulation of protein phosphorylation GO:0003091 renal water homeostasis GO:0006631 fatty acid metabolic process GO:0007596 blood coagulation GO:0007612 learning GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0034199 activation of protein kinase A activity GO:0035556 intracellular signal transduction GO:0045859 regulation of protein kinase activity GO:0071377 cellular response to glucagon stimulus GO:0097332 response to antipsychotic drug GO:0097338 response to clozapine GO:0097711 ciliary basal body docking GO:2000480 negative regulation of cAMP-dependent protein kinase activity
BC075800 - Homo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta, mRNA (cDNA clone MGC:87711 IMAGE:30331962), complete cds. M31158 - Human cAMP-dependent protein kinase subunit RII-beta mRNA, complete cds. A12297 - RII beta cDNA sequence. AK128639 - Homo sapiens cDNA FLJ46798 fis, clone TRACH3031660, highly similar to cAMP-dependent protein kinase type II-beta regulatory subunit. AK291441 - Homo sapiens cDNA FLJ77303 complete cds, highly similar to Homo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B), mRNA. CU687290 - Synthetic construct Homo sapiens gateway clone IMAGE:100022936 5' read PRKAR2B mRNA. AB384742 - Synthetic construct DNA, clone: pF1KB3088, Homo sapiens PRKAR2B gene for cAMP-dependent protein kinase type II-beta regulatory subunit, complete cds, without stop codon, in Flexi system. AM393700 - Synthetic construct Homo sapiens clone IMAGE:100002692 for hypothetical protein (PRKAR2B gene). KJ897379 - Synthetic construct Homo sapiens clone ccsbBroadEn_06773 PRKAR2B gene, encodes complete protein. KJ905286 - Synthetic construct Homo sapiens clone ccsbBroadEn_14787 PRKAR2B gene, encodes complete protein. AM392728 - Synthetic construct Homo sapiens clone IMAGE:100002941 for hypothetical protein (PRKAR2B gene). AM392771 - Synthetic construct Homo sapiens clone IMAGE:100002940 for hypothetical protein (PRKAR2B gene). AM393258 - Synthetic construct Homo sapiens clone IMAGE:100002939 for hypothetical protein (PRKAR2B gene). JD190323 - Sequence 171347 from Patent EP1572962. JD461704 - Sequence 442728 from Patent EP1572962. JD067003 - Sequence 48027 from Patent EP1572962. JD289685 - Sequence 270709 from Patent EP1572962. JD292288 - Sequence 273312 from Patent EP1572962. JD020454 - Sequence 1478 from Patent EP1572962. JD110100 - Sequence 91124 from Patent EP1572962. JD034902 - Sequence 15926 from Patent EP1572962. JD040327 - Sequence 21351 from Patent EP1572962. JD113053 - Sequence 94077 from Patent EP1572962. JD024090 - Sequence 5114 from Patent EP1572962. JD028738 - Sequence 9762 from Patent EP1572962. JD313273 - Sequence 294297 from Patent EP1572962. JD432922 - Sequence 413946 from Patent EP1572962. BC014355 - Homo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta, mRNA (cDNA clone IMAGE:3686556), with apparent retained intron. JD489845 - Sequence 470869 from Patent EP1572962. JD092564 - Sequence 73588 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway h_mCalpainPathway - mCalpain and friends in Cell motility h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_shhPathway - Sonic Hedgehog (Shh) Pathway h_badPathway - Regulation of BAD phosphorylation h_plcePathway - Phospholipase C-epsilon pathway h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_akapCentrosomePathway - Protein Kinase A at the Centrosome h_agpcrPathway - Attenuation of GPCR Signaling h_crebPathway - Transcription factor CREB and its extracellular signals h_no1Pathway - Actions of Nitric Oxide in the Heart h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_gpcrPathway - Signaling Pathway from G-Protein Families
Reactome (by CSHL, EBI, and GO)
Protein P31323 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
