Human Gene PRM3 (ENST00000327157.4_6) from GENCODE V47lift37
  Description: protamine 3 (from RefSeq NM_021247.3)
Gencode Transcript: ENST00000327157.4_6
Gencode Gene: ENSG00000178257.4_8
Transcript (Including UTRs)
   Position: hg19 chr16:11,367,056-11,367,486 Size: 431 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr16:11,367,141-11,367,452 Size: 312 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:11,367,056-11,367,486)mRNA (may differ from genome)Protein (104 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRM3_HUMAN
DESCRIPTION: RecName: Full=Protamine-3; AltName: Full=Sperm protamine P3;
FUNCTION: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome (By similarity).
SIMILARITY: Belongs to the protamine-P3 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 56.55 RPKM in Testis
Total median expression: 56.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.2034-0.153 Picture PostScript Text
3' UTR -22.7085-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026077 - PRMP3

ModBase Predicted Comparative 3D Structure on Q9NNZ6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003677 DNA binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0008150 biological_process
GO:0030154 cell differentiation
GO:0030261 chromosome condensation
GO:0030317 flagellated sperm motility

Cellular Component:
GO:0000786 nucleosome
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC172319 - Synthetic construct Homo sapiens clone IMAGE:100069013, MGC:199024 protamine 3 (PRM3) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000327157.1, ENST00000327157.2, ENST00000327157.3, NM_021247, PRM3_HUMAN, Q9NNZ6, uc317sfi.1, uc317sfi.2
UCSC ID: ENST00000327157.4_6
RefSeq Accession: NM_021247.3
Protein: Q9NNZ6 (aka PRM3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.