ID:ANM1_HUMAN DESCRIPTION: RecName: Full=Protein arginine N-methyltransferase 1; EC=2.1.1.-; AltName: Full=Histone-arginine N-methyltransferase PRMT1; EC=2.1.1.125; AltName: Full=Interferon receptor 1-bound protein 4; FUNCTION: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional acivity. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]. ENZYME REGULATION: By BTG1, BTG2 and ILF3. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1 uM for AdoMet; KM=4.2 uM for H4; Vmax=1.2 nmol/min/mg enzyme toward AdoMet; Vmax=1.24 nmol/min/mg enzyme toward H4; SUBUNIT: Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP AND IFNAR1 (By similarity). Interacts with ILF3 and SUPT5H. Interacts with FOXO1; the interaction methylates FOXO1, retaining it in the nucleus and increasing its transcriptional activity. Methylation of FOXO1 is increased with oxidative stress. INTERACTION: Q08211:DHX9; NbExp=2; IntAct=EBI-78738, EBI-352022; P04591:gag (xeno); NbExp=2; IntAct=EBI-78738, EBI-6179727; Q5JVS0:HABP4; NbExp=2; IntAct=EBI-78738, EBI-523625; Q12906:ILF3; NbExp=2; IntAct=EBI-78738, EBI-78756; SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol (By similarity). TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the protein arginine N-methyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99873
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK304660 - Homo sapiens cDNA FLJ55610 complete cds, highly similar to Protein arginine N-methyltransferase 1 (EC 2.1.1.-). AK295973 - Homo sapiens cDNA FLJ60588 complete cds, highly similar to Protein arginine N-methyltransferase 1 (EC 2.1.1.-). AB590883 - Synthetic construct DNA, clone: pFN21AE1854, Homo sapiens PRMT1 gene for protein arginine methyltransferase 1, without stop codon, in Flexi system. BC019268 - Homo sapiens protein arginine methyltransferase 1, mRNA (cDNA clone IMAGE:2823702), partial cds. AY775289 - Homo sapiens protein arginine methyltransferase 1 isoform 4 (HRMT1L2) mRNA, complete cds, alternatively spliced. D66904 - Homo sapiens mRNA, complete cds, suppressor for yeast mutant. Y10805 - H.sapiens mRNA for arginine methyltransferase, splice variant, 1435 bp. Y10806 - H.sapiens mRNA for arginine methyltransferase, splice variant, 1316 bp. Y10807 - H.sapiens mRNA for arginine methyltransferase, splice variant, 1262 bp. BC109282 - Homo sapiens protein arginine methyltransferase 1, mRNA (cDNA clone MGC:129947 IMAGE:40031731), complete cds. BC109283 - Homo sapiens protein arginine methyltransferase 1, mRNA (cDNA clone MGC:129948 IMAGE:40031735), complete cds. CR407608 - Homo sapiens full open reading frame cDNA clone RZPDo834A082D for gene HRMT1L2, HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) complete cds, without stopcodon. KJ904482 - Synthetic construct Homo sapiens clone ccsbBroadEn_13876 PRMT1 gene, encodes complete protein. EU446980 - Synthetic construct Homo sapiens clone IMAGE:100069881; IMAGE:100012189; FLH258583.01L protein arginine methyltransferase 1 (PRMT1) gene, encodes complete protein. DQ599702 - Homo sapiens piRNA piR-37768, complete sequence. AF085918 - Homo sapiens full length insert cDNA clone YR23E03. DQ586593 - Homo sapiens piRNA piR-53705, complete sequence. DQ586594 - Homo sapiens piRNA piR-53706, complete sequence. AK301038 - Homo sapiens cDNA FLJ58951 complete cds. JD335500 - Sequence 316524 from Patent EP1572962. KX421002 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 5 (PRMT1) mRNA, complete cds, alternatively spliced. KX421003 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 6 (PRMT1) mRNA, complete cds, alternatively spliced. KX421004 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 7 (PRMT1) mRNA, complete cds, alternatively spliced. KX421005 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 8 (PRMT1) mRNA, complete cds, alternatively spliced. KX421006 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 9 (PRMT1) mRNA, complete cds, alternatively spliced. KX421007 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 10 (PRMT1) mRNA, complete cds, alternatively spliced. KX421008 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 11 (PRMT1) mRNA, complete cds, alternatively spliced. KX421009 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 12 (PRMT1) mRNA, complete cds, alternatively spliced. KX421010 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 13 (PRMT1) mRNA, complete cds, alternatively spliced. KX421011 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 14 (PRMT1) mRNA, complete cds, alternatively spliced. KX421012 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 15 (PRMT1) mRNA, complete cds, alternatively spliced. KX421013 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 16 (PRMT1) mRNA, complete cds, alternatively spliced. KX421014 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 17 (PRMT1) mRNA, complete cds, alternatively spliced. KX421015 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 18 (PRMT1) mRNA, complete cds, alternatively spliced. KX421016 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 19 (PRMT1) mRNA, complete cds, alternatively spliced. KX421017 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 20 (PRMT1) mRNA, complete cds, alternatively spliced. KX421018 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 21 (PRMT1) mRNA, complete cds, alternatively spliced. KX421019 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 22 (PRMT1) mRNA, complete cds, alternatively spliced. KX421020 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 23 (PRMT1) mRNA, complete cds, alternatively spliced. KX421021 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 24 (PRMT1) mRNA, complete cds, alternatively spliced. KX421022 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 25 (PRMT1) mRNA, complete cds, alternatively spliced. KX421023 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 26 (PRMT1) mRNA, complete cds, alternatively spliced. KX421024 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 27 (PRMT1) mRNA, complete cds, alternatively spliced. KX421025 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 28 (PRMT1) mRNA, complete cds, alternatively spliced. KX421026 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 29 (PRMT1) mRNA, complete cds, alternatively spliced. KX421027 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 30 (PRMT1) mRNA, complete cds, alternatively spliced. KX421028 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 31 (PRMT1) mRNA, complete cds, alternatively spliced. KX421029 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 32 (PRMT1) mRNA, complete cds, alternatively spliced. KX421030 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 33 (PRMT1) mRNA, complete cds, alternatively spliced. KX421031 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 34 (PRMT1) mRNA, complete cds, alternatively spliced. KX421032 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 35 (PRMT1) mRNA, complete cds, alternatively spliced. KX421033 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 36 (PRMT1) mRNA, complete cds, alternatively spliced. KX421034 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 37 (PRMT1) mRNA, complete cds, alternatively spliced. KX421035 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 38 (PRMT1) mRNA, complete cds, alternatively spliced. KX421036 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 39 (PRMT1) mRNA, complete cds, alternatively spliced. KX421037 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 40 (PRMT1) mRNA, complete cds, alternatively spliced. KX421038 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 41 (PRMT1) mRNA, complete cds, alternatively spliced. KX421039 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 42 (PRMT1) mRNA, complete cds, alternatively spliced. KX421040 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 43 (PRMT1) mRNA, complete cds, alternatively spliced. KX421041 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 44 (PRMT1) mRNA, complete cds, alternatively spliced. KX421042 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 45 (PRMT1) mRNA, complete cds, alternatively spliced. KX421043 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 46 (PRMT1) mRNA, complete cds, alternatively spliced. KX421044 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 47 (PRMT1) mRNA, complete cds, alternatively spliced. KX421045 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 48 (PRMT1) mRNA, complete cds, alternatively spliced. KX421046 - Homo sapiens protein arginine N-methyltransferase 1 transcript variant 49 (PRMT1) mRNA, complete cds, alternatively spliced. KX421047 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 50 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421048 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 51 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421049 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 52 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421050 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 53 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421051 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 54 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421052 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 55 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421053 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 56 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421054 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 57 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421055 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 58 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421056 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 59 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421057 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 60 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421058 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 61 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421059 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 62 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421060 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 63 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421061 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 64 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421062 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 65 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421063 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 66 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421064 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 67 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421065 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 68 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421066 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 69 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421067 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 70 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421068 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 71 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421069 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 72 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421070 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 73 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421071 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 74 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421072 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 75 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421073 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 76 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421074 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 77 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421075 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 78 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421076 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 79 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421077 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 80 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421078 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 81 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421079 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 82 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421080 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 83 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421081 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 84 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421082 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 85 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421083 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 86 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421084 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 87 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421085 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 88 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421086 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 89 (PRMT1) mRNA, partial sequence; alternatively spliced. KX421087 - Homo sapiens nonfunctional protein arginine methyltransferase 1 transcript variant 90 (PRMT1) mRNA, partial sequence; alternatively spliced.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_btg2Pathway - BTG family proteins and cell cycle regulation h_vdrPathway - Control of Gene Expression by Vitamin D Receptor
Reactome (by CSHL, EBI, and GO)
Protein Q99873 (Reactome details) participates in the following event(s):
R-HSA-3215152 TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter R-HSA-8934742 RUNX1 binds PRMT1 R-HSA-9023861 PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene R-HSA-8934735 PRMT1 arginine-methylates RUNX1 R-HSA-5205867 PRMT1 methylates arginine-12 of histone H2A (H2AR11) R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene R-HSA-9023860 Histone acetyltransferases are recruited to the TFF1 gene R-HSA-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4 R-HSA-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-9018519 Estrogen-dependent gene expression R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-8878171 Transcriptional regulation by RUNX1 R-HSA-8939211 ESR-mediated signaling R-HSA-3214858 RMTs methylate histone arginines R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-212436 Generic Transcription Pathway R-HSA-9006931 Signaling by Nuclear Receptors R-HSA-3247509 Chromatin modifying enzymes R-HSA-73857 RNA Polymerase II Transcription R-HSA-162582 Signal Transduction R-HSA-4839726 Chromatin organization R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
