Human Gene PRMT7 (ENST00000441236.3_4) from GENCODE V47lift37
  Description: protein arginine methyltransferase 7, transcript variant 22 (from RefSeq NR_165373.1)
Gencode Transcript: ENST00000441236.3_4
Gencode Gene: ENSG00000132600.18_15
Transcript (Including UTRs)
   Position: hg19 chr16:68,344,922-68,392,487 Size: 47,566 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr16:68,349,883-68,391,127 Size: 41,245 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:68,344,922-68,392,487)mRNA (may differ from genome)Protein (692 aa)
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UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANM7_HUMAN
DESCRIPTION: RecName: Full=Protein arginine N-methyltransferase 7; EC=2.1.1.-; AltName: Full=Histone-arginine N-methyltransferase PRMT7; EC=2.1.1.125; AltName: Full=[Myelin basic protein]-arginine N-methyltransferase PRMT7; EC=2.1.1.126;
FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
SUBUNIT: Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus.
MISCELLANEOUS: May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
SIMILARITY: Belongs to the protein arginine N-methyltransferase family. PRMT7 subfamily.
SEQUENCE CAUTION: Sequence=BAB14215.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PRMT7
Diseases sorted by gene-association score: short stature, brachydactyly, intellectual developmental disability, and seizures* (1581), brachydactyly (12), citrullinemia (10), syndromic intellectual disability (7), intellectual disability (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.06 RPKM in Brain - Cerebellum
Total median expression: 291.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.50299-0.423 Picture PostScript Text
3' UTR -562.101360-0.413 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025799 - Arg_MeTrfase
IPR025801 - Arg_MeTrfase_PMTR7_chr
IPR014644 - Arg_MeTrfase_PRMT7
IPR010456 - Ribosomal-L11_MeTrfase_PrmA

Pfam Domains:
PF06325 - Ribosomal protein L11 methyltransferase (PrmA)

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q9NVM4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity
GO:0042393 histone binding
GO:0043021 ribonucleoprotein complex binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)

Biological Process:
GO:0000387 spliceosomal snRNP assembly
GO:0006325 chromatin organization
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0016571 histone methylation
GO:0018216 peptidyl-arginine methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030154 cell differentiation
GO:0032259 methylation
GO:0034969 histone arginine methylation
GO:0035246 peptidyl-arginine N-methylation
GO:0035247 peptidyl-arginine omega-N-methylation
GO:0043046 DNA methylation involved in gamete generation
GO:0043393 regulation of protein binding
GO:0043985 histone H4-R3 methylation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK001502 - Homo sapiens cDNA FLJ10640 fis, clone NT2RP2005723, weakly similar to HNRNP ARGININE N-METHYLTRANSFERASE (EC 2.1.1.-).
AK304605 - Homo sapiens cDNA FLJ58467 complete cds, highly similar to Protein arginine N-methyltransferase 7 (EC 2.1.1.-).
AK056647 - Homo sapiens cDNA FLJ32085 fis, clone OCBBF2000323, highly similar to Protein arginine N-methyltransferase 7 (EC 2.1.1.-).
JD367143 - Sequence 348167 from Patent EP1572962.
JD325745 - Sequence 306769 from Patent EP1572962.
JD419651 - Sequence 400675 from Patent EP1572962.
JD423992 - Sequence 405016 from Patent EP1572962.
JD200395 - Sequence 181419 from Patent EP1572962.
JD536459 - Sequence 517483 from Patent EP1572962.
JD536460 - Sequence 517484 from Patent EP1572962.
JD459576 - Sequence 440600 from Patent EP1572962.
JD459577 - Sequence 440601 from Patent EP1572962.
JD130369 - Sequence 111393 from Patent EP1572962.
JD411596 - Sequence 392620 from Patent EP1572962.
JD071954 - Sequence 52978 from Patent EP1572962.
AK097175 - Homo sapiens cDNA FLJ39856 fis, clone SPLEN2014924, highly similar to Protein arginine N-methyltransferase 7 (EC 2.1.1.-).
BC000146 - Homo sapiens protein arginine methyltransferase 7, mRNA (cDNA clone MGC:5331 IMAGE:2900965), complete cds.
JD049495 - Sequence 30519 from Patent EP1572962.
JD435280 - Sequence 416304 from Patent EP1572962.
AB067520 - Homo sapiens mRNA for KIAA1933 protein, partial cds.
AK022739 - Homo sapiens cDNA FLJ12677 fis, clone NT2RM4002398.
AK123945 - Homo sapiens cDNA FLJ41951 fis, clone PROST1000528.
JD515093 - Sequence 496117 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVM4 (Reactome details) participates in the following event(s):

R-HSA-5218952 PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: ANM7_HUMAN, B3KPR0, B3KUG9, B4E379, ENST00000441236.1, ENST00000441236.2, KIAA1933, NR_165373, Q96PV5, Q9H9L0, Q9NVM4, uc320jja.1, uc320jja.2
UCSC ID: ENST00000441236.3_4
RefSeq Accession: NM_019023.5
Protein: Q9NVM4 (aka ANM7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.