Human Gene PRND (ENST00000305817.3_4) from GENCODE V47lift37

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Description: prion like protein doppel (from RefSeq NM_012409.4)
Gencode Transcript: ENST00000305817.3_4
Gencode Gene: ENSG00000171864.5_7
Transcript (Including UTRs)
Position: hg19 chr20:4,702,555-4,709,106 Size: 6,552 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr20:4,705,198-4,705,728 Size: 531 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:4,702,555-4,709,106)			mRNA (may differ from genome)		Protein (176 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PRND_HUMAN DESCRIPTION: RecName: Full=Prion-like protein doppel; AltName: Full=PrPLP; AltName: Full=Prion protein 2; Flags: Precursor; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). TISSUE SPECIFICITY: Expressed in testis. SIMILARITY: Belongs to the prion family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PRND Diseases sorted by gene-association score: creutzfeldt-jakob disease (35), prion disease (20), scrapie (19), insomnia, fatal familial (9), astrocytoma (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002945 Cisplatin D003300 Copper D004041 Dietary Fats D007545 Isoproterenol C041786 palm oil C017947 sodium arsenite

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 64.85 RPKM in Testis Total median expression: 67.40 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-24.30	72	-0.337	Picture	PostScript	Text
3' UTR	-969.30	3378	-0.287	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR021566 - Doppel
IPR022416 - Prion/Doppel_prot_b-ribbon_dom

Pfam Domains:
PF00377 - Prion/Doppel alpha-helical domain
PF11466 - Prion-like protein Doppel

SCOP Domains:
54098 - Prion-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1LG4 - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q9UKY0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005507 copper ion binding GO:0046872 metal ion binding Biological Process: GO:0006878 cellular copper ion homeostasis GO:0007338 single fertilization GO:0007340 acrosome reaction GO:0051260 protein homooligomerization Cellular Component: GO:0005576 extracellular region GO:0005886 plasma membrane GO:0016020 membrane GO:0031225 anchored component of membrane GO:0031362 anchored component of external side of plasma membrane

Descriptions from all associated GenBank mRNAs


	AK313404 - Homo sapiens cDNA, FLJ93940, Homo sapiens prion gene complex, downstream (PRND), mRNA. BC043644 - Homo sapiens prion protein 2 (dublet), mRNA (cDNA clone MGC:41841 IMAGE:5272576), complete cds. AF187843 - Homo sapiens doppel protein (PRND) mRNA, partial cds. AY358985 - Homo sapiens clone DNA87991 PRND (UNQ1830) mRNA, complete cds. AF187844 - Homo sapiens prion-like protein (PRND) mRNA, complete cds. JD290578 - Sequence 271602 from Patent EP1572962. CU692184 - Synthetic construct Homo sapiens gateway clone IMAGE:100020807 5' read PRND mRNA. HQ448044 - Synthetic construct Homo sapiens clone IMAGE:100071420; CCSB010476_04 prion protein 2 (dublet) (PRND) gene, encodes complete protein. KJ898525 - Synthetic construct Homo sapiens clone ccsbBroadEn_07919 PRND gene, encodes complete protein. JD201595 - Sequence 182619 from Patent EP1572962. JD067100 - Sequence 48124 from Patent EP1572962. JD530526 - Sequence 511550 from Patent EP1572962. JD367002 - Sequence 348026 from Patent EP1572962. JD164673 - Sequence 145697 from Patent EP1572962. JD049439 - Sequence 30463 from Patent EP1572962. JD308558 - Sequence 289582 from Patent EP1572962. JD065287 - Sequence 46311 from Patent EP1572962. JD069065 - Sequence 50089 from Patent EP1572962. JD296066 - Sequence 277090 from Patent EP1572962. JD161174 - Sequence 142198 from Patent EP1572962. JD363573 - Sequence 344597 from Patent EP1572962. JD548405 - Sequence 529429 from Patent EP1572962. JD121442 - Sequence 102466 from Patent EP1572962. JD553616 - Sequence 534640 from Patent EP1572962. JD563433 - Sequence 544457 from Patent EP1572962. JD507790 - Sequence 488814 from Patent EP1572962. JD286193 - Sequence 267217 from Patent EP1572962. JD562136 - Sequence 543160 from Patent EP1572962. JD293303 - Sequence 274327 from Patent EP1572962. JD142117 - Sequence 123141 from Patent EP1572962. JD454970 - Sequence 435994 from Patent EP1572962. JD536725 - Sequence 517749 from Patent EP1572962. JD252507 - Sequence 233531 from Patent EP1572962. JD207718 - Sequence 188742 from Patent EP1572962. JD285606 - Sequence 266630 from Patent EP1572962. JD455935 - Sequence 436959 from Patent EP1572962. JD385843 - Sequence 366867 from Patent EP1572962. JD111224 - Sequence 92248 from Patent EP1572962. JD321606 - Sequence 302630 from Patent EP1572962. JD284624 - Sequence 265648 from Patent EP1572962. JD150164 - Sequence 131188 from Patent EP1572962. JD334035 - Sequence 315059 from Patent EP1572962. JD186287 - Sequence 167311 from Patent EP1572962. JD068197 - Sequence 49221 from Patent EP1572962. JD320401 - Sequence 301425 from Patent EP1572962. JD378642 - Sequence 359666 from Patent EP1572962. JD043523 - Sequence 24547 from Patent EP1572962. JD140534 - Sequence 121558 from Patent EP1572962. JD081718 - Sequence 62742 from Patent EP1572962. JD551768 - Sequence 532792 from Patent EP1572962. JD360197 - Sequence 341221 from Patent EP1572962. JD542840 - Sequence 523864 from Patent EP1572962. JD212835 - Sequence 193859 from Patent EP1572962. AF086354 - Homo sapiens full length insert cDNA clone ZD63E04. JD249163 - Sequence 230187 from Patent EP1572962. JD086412 - Sequence 67436 from Patent EP1572962. JD121114 - Sequence 102138 from Patent EP1572962. JD381331 - Sequence 362355 from Patent EP1572962. JD381332 - Sequence 362356 from Patent EP1572962. JD344129 - Sequence 325153 from Patent EP1572962. JD356529 - Sequence 337553 from Patent EP1572962. JD552358 - Sequence 533382 from Patent EP1572962. JD242673 - Sequence 223697 from Patent EP1572962. JD342229 - Sequence 323253 from Patent EP1572962. JD480476 - Sequence 461500 from Patent EP1572962. JD435401 - Sequence 416425 from Patent EP1572962. JD506290 - Sequence 487314 from Patent EP1572962. JD232899 - Sequence 213923 from Patent EP1572962. JD145213 - Sequence 126237 from Patent EP1572962. JD280737 - Sequence 261761 from Patent EP1572962. JD231043 - Sequence 212067 from Patent EP1572962. JD096646 - Sequence 77670 from Patent EP1572962. JD326213 - Sequence 307237 from Patent EP1572962. JD292958 - Sequence 273982 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9UKY0 (Reactome details) participates in the following event(s): R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A7U7M5, DPL, ENST00000305817.1, ENST00000305817.2, NM_012409, PRND_HUMAN, Q9H311, Q9H312, Q9NTM4, Q9UKY0, uc317nrx.1, uc317nrx.2, UNQ1830/PRO3443 UCSC ID: ENST00000305817.3_4 RefSeq Accession: NM_012409.4 Protein: Q9UKY0 (aka PRND_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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