ID:PROP1_HUMAN DESCRIPTION: RecName: Full=Homeobox protein prophet of Pit-1; Short=PROP-1; AltName: Full=Pituitary-specific homeodomain factor; FUNCTION: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed specifically in embryonic pituitary. DISEASE: Defects in PROP1 are the cause of pituitary hormone deficiency combined type 2 (CPHD2) [MIM:262600]; also known as pituitary dwarfism III. It is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones. SIMILARITY: Belongs to the paired homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PROP1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75360
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0008022 protein C-terminus binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001568 blood vessel development GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007417 central nervous system development GO:0009887 animal organ morphogenesis GO:0009953 dorsal/ventral pattern formation GO:0016477 cell migration GO:0021979 hypothalamus cell differentiation GO:0021984 adenohypophysis development GO:0043066 negative regulation of apoptotic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048732 gland development GO:0048850 hypophysis morphogenesis GO:0060070 canonical Wnt signaling pathway GO:0060126 somatotropin secreting cell differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
