Human Gene PRR12 (ENST00000418929.7_7) from GENCODE V47lift37
  Description: proline rich 12 (from RefSeq NM_020719.3)
Gencode Transcript: ENST00000418929.7_7
Gencode Gene: ENSG00000126464.15_10
Transcript (Including UTRs)
   Position: hg19 chr19:50,094,439-50,129,696 Size: 35,258 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr19:50,094,912-50,128,864 Size: 33,953 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:50,094,439-50,129,696)mRNA (may differ from genome)Protein (2036 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRR12_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 12;
SIMILARITY: Contains 2 A.T hook DNA-binding domains.
SEQUENCE CAUTION: Sequence=BAA86519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PRR12
Diseases sorted by gene-association score: intellectual disability (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.11 RPKM in Brain - Cerebellum
Total median expression: 432.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -222.00473-0.469 Picture PostScript Text
3' UTR -298.00832-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017956 - AT_hook_DNA-bd_motif
IPR025451 - DUF4211

Pfam Domains:
PF13926 - Domain of unknown function (DUF4211)

ModBase Predicted Comparative 3D Structure on Q9ULL5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane


-  Descriptions from all associated GenBank mRNAs
  AB033031 - Homo sapiens mRNA for KIAA1205 protein, partial cds.
AB384139 - Synthetic construct DNA, clone: pF1KSDA1205, Homo sapiens PRR12 gene for proline-rich protein 12, complete cds, without stop codon, in Flexi system.
LF207659 - JP 2014500723-A/15162: Polycomb-Associated Non-Coding RNAs.
LF367764 - JP 2014500723-A/175267: Polycomb-Associated Non-Coding RNAs.
LF367763 - JP 2014500723-A/175266: Polycomb-Associated Non-Coding RNAs.
BC034003 - Homo sapiens proline rich 12, mRNA (cDNA clone IMAGE:5421551), partial cds.
JD137986 - Sequence 119010 from Patent EP1572962.
JD111981 - Sequence 93005 from Patent EP1572962.
JD223849 - Sequence 204873 from Patent EP1572962.
JD120947 - Sequence 101971 from Patent EP1572962.
JD335775 - Sequence 316799 from Patent EP1572962.
JD335776 - Sequence 316800 from Patent EP1572962.
JD307575 - Sequence 288599 from Patent EP1572962.
JD389427 - Sequence 370451 from Patent EP1572962.
JD134766 - Sequence 115790 from Patent EP1572962.
JD560862 - Sequence 541886 from Patent EP1572962.
JD223072 - Sequence 204096 from Patent EP1572962.
JD239128 - Sequence 220152 from Patent EP1572962.
JD045736 - Sequence 26760 from Patent EP1572962.
JD390721 - Sequence 371745 from Patent EP1572962.
JD548384 - Sequence 529408 from Patent EP1572962.
JD190902 - Sequence 171926 from Patent EP1572962.
JD510451 - Sequence 491475 from Patent EP1572962.
JD121717 - Sequence 102741 from Patent EP1572962.
MA603341 - JP 2018138019-A/175267: Polycomb-Associated Non-Coding RNAs.
MA603340 - JP 2018138019-A/175266: Polycomb-Associated Non-Coding RNAs.
MA443236 - JP 2018138019-A/15162: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PB06, ENST00000418929.1, ENST00000418929.2, ENST00000418929.3, ENST00000418929.4, ENST00000418929.5, ENST00000418929.6, KIAA1205, NM_020719, PRR12 , PRR12_HUMAN, Q8N4J6, Q9ULL5, uc319omw.1, uc319omw.2
UCSC ID: ENST00000418929.7_7
RefSeq Accession: NM_020719.3
Protein: Q9ULL5 (aka PRR12_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.