Human Gene PRR14L (ENST00000327423.11_8) from GENCODE V47lift37
  Description: proline rich 14 like (from RefSeq NM_173566.3)
Gencode Transcript: ENST00000327423.11_8
Gencode Gene: ENSG00000183530.14_12
Transcript (Including UTRs)
   Position: hg19 chr22:32,077,333-32,146,118 Size: 68,786 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr22:32,081,513-32,134,846 Size: 53,334 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:32,077,333-32,146,118)mRNA (may differ from genome)Protein (2151 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PR14L_HUMAN
DESCRIPTION: RecName: Full=Protein PRR14L; AltName: Full=Proline rich 14-like protein;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE CAUTION: Sequence=AAH40859.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15536.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15536.1; Type=Frameshift; Positions=1174; Sequence=BAC85470.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC85533.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI22445.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.84 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 180.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.20191-0.436 Picture PostScript Text
3' UTR -1340.504180-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026320 - PRR14

Pfam Domains:
PF15386 - Drosophila Tantalus-like

ModBase Predicted Comparative 3D Structure on Q5THK1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  CT841517 - Homo sapiens dJ694E4.2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ694E4.2.V3).
BC040859 - Homo sapiens chromosome 22 open reading frame 30, mRNA (cDNA clone MGC:50372 IMAGE:5535580), complete cds.
HQ448629 - Synthetic construct Homo sapiens clone IMAGE:100072068; CCSB011348_02 chromosome 22 open reading frame 30 (C22orf30) gene, encodes complete protein.
KJ904054 - Synthetic construct Homo sapiens clone ccsbBroadEn_13448 PRR14L gene, encodes complete protein.
CU691928 - Synthetic construct Homo sapiens gateway clone IMAGE:100021371 5' read C22orf30 mRNA.
BX647272 - Homo sapiens mRNA; cDNA DKFZp781P2328 (from clone DKFZp781P2328).
AK055930 - Homo sapiens cDNA FLJ31368 fis, clone NB9N42000042.
AK090566 - Homo sapiens cDNA FLJ33247 fis, clone ASTRO2004974.
AK123082 - Homo sapiens cDNA FLJ41087 fis, clone ADRGL2012179.
JD057711 - Sequence 38735 from Patent EP1572962.
JD270358 - Sequence 251382 from Patent EP1572962.
JD321845 - Sequence 302869 from Patent EP1572962.
JD253097 - Sequence 234121 from Patent EP1572962.
JD428232 - Sequence 409256 from Patent EP1572962.
AK130944 - Homo sapiens cDNA FLJ27434 fis, clone WMD09549.
JD392720 - Sequence 373744 from Patent EP1572962.
JD514205 - Sequence 495229 from Patent EP1572962.
JD444744 - Sequence 425768 from Patent EP1572962.
JD103857 - Sequence 84881 from Patent EP1572962.
JD367763 - Sequence 348787 from Patent EP1572962.
JD214452 - Sequence 195476 from Patent EP1572962.
JD060555 - Sequence 41579 from Patent EP1572962.
JD203493 - Sequence 184517 from Patent EP1572962.
JD312285 - Sequence 293309 from Patent EP1572962.
JD067934 - Sequence 48958 from Patent EP1572962.
JD023229 - Sequence 4253 from Patent EP1572962.
JD031439 - Sequence 12463 from Patent EP1572962.
JD034108 - Sequence 15132 from Patent EP1572962.
AK026712 - Homo sapiens cDNA: FLJ23059 fis, clone LNG03912.

-  Other Names for This Gene
  Alternate Gene Symbols: C22orf30, ENST00000327423.1, ENST00000327423.10, ENST00000327423.2, ENST00000327423.3, ENST00000327423.4, ENST00000327423.5, ENST00000327423.6, ENST00000327423.7, ENST00000327423.8, ENST00000327423.9, NM_173566, PR14L_HUMAN, Q5THK1, Q5THK4, Q6ZNN1, Q6ZWH0, Q8IW74, Q9H5T4, uc317sgw.1, uc317sgw.2
UCSC ID: ENST00000327423.11_8
RefSeq Accession: NM_173566.3
Protein: Q5THK1 (aka PR14L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.