Human Gene PRSS16 (ENST00000230582.8_4) from GENCODE V47lift37

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Description: serine protease 16 (from RefSeq NM_005865.4)
Gencode Transcript: ENST00000230582.8_4
Gencode Gene: ENSG00000112812.16_11
Transcript (Including UTRs)
Position: hg19 chr6:27,215,480-27,224,399 Size: 8,920 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr6:27,215,517-27,223,094 Size: 7,578 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:27,215,480-27,224,399)			mRNA (may differ from genome)		Protein (514 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TSSP_HUMAN DESCRIPTION: RecName: Full=Thymus-specific serine protease; EC=3.4.-.-; AltName: Full=Serine protease 16; Flags: Precursor; FUNCTION: Protease that may play a role in T-cell development. SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal. TISSUE SPECIFICITY: Expressed predominantly in cortical thymic epithelial cells. DEVELOPMENTAL STAGE: Expressed in fetal thymus. SIMILARITY: Belongs to the peptidase S28 family. SEQUENCE CAUTION: Sequence=CAB94769.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PRSS16 Diseases sorted by gene-association score: diabetes mellitus, insulin-dependent (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C547126 AZM551248 D001280 Atrazine D002794 Choline D004041 Dietary Fats D004997 Ethinyl Estradiol D005492 Folic Acid D008715 Methionine C513635 S-2-pentyl-4-pentynoic hydroxamic acid D012906 Smoke D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C496492 abrine C069837 fullerene C60 C028007 nickel monoxide C059514 resveratrol

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.96 RPKM in Pancreas Total median expression: 72.70 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.20	37	-0.222	Picture	PostScript	Text
3' UTR	-255.40	1305	-0.196	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008758 - Peptidase_S28

Pfam Domains:
PF05577 - Serine carboxypeptidase S28

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q9NQE7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008233 peptidase activity GO:0008236 serine-type peptidase activity GO:0008239 dipeptidyl-peptidase activity GO:0016787 hydrolase activity Biological Process: GO:0006508 proteolysis GO:0030163 protein catabolic process Cellular Component: GO:0005764 lysosome GO:0005768 endosome GO:0031410 cytoplasmic vesicle

Descriptions from all associated GenBank mRNAs


	LF209709 - JP 2014500723-A/17212: Polycomb-Associated Non-Coding RNAs. AK097918 - Homo sapiens cDNA FLJ40599 fis, clone THYMU2011183, highly similar to Thymus-specific serine protease precursor (EC3.4.-.-). AK314037 - Homo sapiens cDNA, FLJ94697. AF052514 - Homo sapiens thymus specific serine peptidase mRNA, complete cds. AK303106 - Homo sapiens cDNA FLJ52815 complete cds, highly similar to Thymus-specific serine protease precursor (EC 3.4.-.-). BC156191 - Synthetic construct Homo sapiens clone IMAGE:100061621, MGC:190054 protease, serine, 16 (thymus) (PRSS16) mRNA, encodes complete protein. BC156928 - Synthetic construct Homo sapiens clone IMAGE:100063590, MGC:190800 protease, serine, 16 (thymus) (PRSS16) mRNA, encodes complete protein. AB590521 - Synthetic construct DNA, clone: pFN21AE1958, Homo sapiens PRSS16 gene for protease, serine, 16, without stop codon, in Flexi system. AY305022 - Homo sapiens thymus specific serine peptidase mRNA, partial cds, alternatively spliced. AY305023 - Homo sapiens thymus specific serine peptidase mRNA, partial cds, alternatively spliced. AY305024 - Homo sapiens thymus specific serine peptidase mRNA, partial cds, alternatively spliced. AY305025 - Homo sapiens thymus specific serine peptidase mRNA, partial cds, alternatively spliced. LF213305 - JP 2014500723-A/20808: Polycomb-Associated Non-Coding RNAs. LF331276 - JP 2014500723-A/138779: Polycomb-Associated Non-Coding RNAs. LF209711 - JP 2014500723-A/17214: Polycomb-Associated Non-Coding RNAs. AK226091 - Homo sapiens mRNA for Hypothetical protein FLJ44172 variant, clone: bm05725. AK126160 - Homo sapiens cDNA FLJ44172 fis, clone THYMU2036085. AK093590 - Homo sapiens cDNA FLJ36271 fis, clone THYMU2003069. AX748218 - Sequence 1743 from Patent EP1308459. AK098033 - Homo sapiens cDNA FLJ40714 fis, clone THYMU2027739. JD366898 - Sequence 347922 from Patent EP1572962. JD301988 - Sequence 283012 from Patent EP1572962. JD252450 - Sequence 233474 from Patent EP1572962. JD246053 - Sequence 227077 from Patent EP1572962. JD094498 - Sequence 75522 from Patent EP1572962. JD305885 - Sequence 286909 from Patent EP1572962. JD149544 - Sequence 130568 from Patent EP1572962. JD507738 - Sequence 488762 from Patent EP1572962. JD160314 - Sequence 141338 from Patent EP1572962. JD521636 - Sequence 502660 from Patent EP1572962. JD162711 - Sequence 143735 from Patent EP1572962. JD396468 - Sequence 377492 from Patent EP1572962. JD465435 - Sequence 446459 from Patent EP1572962. JD212151 - Sequence 193175 from Patent EP1572962. JD547370 - Sequence 528394 from Patent EP1572962. JD048198 - Sequence 29222 from Patent EP1572962. JD392539 - Sequence 373563 from Patent EP1572962. JD547370 - Sequence 528394 from Patent EP1572962. JD048198 - Sequence 29222 from Patent EP1572962. JD392539 - Sequence 373563 from Patent EP1572962. JD548241 - Sequence 529265 from Patent EP1572962. JD419206 - Sequence 400230 from Patent EP1572962. JD418058 - Sequence 399082 from Patent EP1572962. JD300133 - Sequence 281157 from Patent EP1572962. JD261389 - Sequence 242413 from Patent EP1572962. JD055943 - Sequence 36967 from Patent EP1572962. JD519875 - Sequence 500899 from Patent EP1572962. JD402842 - Sequence 383866 from Patent EP1572962. JD528756 - Sequence 509780 from Patent EP1572962. MA566853 - JP 2018138019-A/138779: Polycomb-Associated Non-Coding RNAs. MA445286 - JP 2018138019-A/17212: Polycomb-Associated Non-Coding RNAs. MA448882 - JP 2018138019-A/20808: Polycomb-Associated Non-Coding RNAs. MA445288 - JP 2018138019-A/17214: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000230582.1, ENST00000230582.2, ENST00000230582.3, ENST00000230582.4, ENST00000230582.5, ENST00000230582.6, ENST00000230582.7, NM_005865, O75416, Q9NQE7, TSSP, TSSP_HUMAN, uc317dtc.1, uc317dtc.2 UCSC ID: ENST00000230582.8_4 RefSeq Accession: NM_005865.4 Protein: Q9NQE7 (aka TSSP_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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