Human Gene PSMB8 (ENST00000374882.8_8) from GENCODE V47lift37
  Description: proteasome 20S subunit beta 8, transcript variant 2 (from RefSeq NM_148919.4)
Gencode Transcript: ENST00000374882.8_8
Gencode Gene: ENSG00000204264.12_12
Transcript (Including UTRs)
   Position: hg19 chr6:32,808,494-32,811,824 Size: 3,331 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr6:32,808,736-32,811,773 Size: 3,038 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:32,808,494-32,811,824)mRNA (may differ from genome)Protein (276 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PSMB8
Diseases sorted by gene-association score: autoinflammation, lipodystrophy, and dermatosis syndrome* (1650), nakajo syndrome* (429), jmp syndrome (17), cardiac sarcoidosis (15), microcytic anemia (13), panniculitis (9), lipodystrophy (8), adiposis dolorosa (7), renal cell carcinoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 178.70 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1741.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.2051-0.220 Picture PostScript Text
3' UTR -91.90242-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Descriptions from all associated GenBank mRNAs
  LF210795 - JP 2014500723-A/18298: Polycomb-Associated Non-Coding RNAs.
JD345400 - Sequence 326424 from Patent EP1572962.
LQ882894 - Sequence 43 from Patent WO2018160841.
BC001114 - Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), mRNA (cDNA clone MGC:1491 IMAGE:2967119), complete cds.
JD334633 - Sequence 315657 from Patent EP1572962.
JD068298 - Sequence 49322 from Patent EP1572962.
JD057867 - Sequence 38891 from Patent EP1572962.
X62598 - H.sapiens RING10 mRNA.
U17496 - Human proteasome subunit LMP7 (allele LMP7B) mRNA, complete cds.
U17497 - Human proteasome subunit LMP7 (allele LMP7C) mRNA, complete cds.
JD475272 - Sequence 456296 from Patent EP1572962.
JD187705 - Sequence 168729 from Patent EP1572962.
JD350222 - Sequence 331246 from Patent EP1572962.
KJ891918 - Synthetic construct Homo sapiens clone ccsbBroadEn_01312 PSMB8 gene, encodes complete protein.
AB464084 - Synthetic construct DNA, clone: pF1KB6395, Homo sapiens PSMB8 gene for proteasome (prosome, macropain) subunit beta type 8, without stop codon, in Flexi system.
CR541661 - Homo sapiens full open reading frame cDNA clone RZPDo834D1127D for gene PSMB8, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7); complete cds, without stopcodon.
LF341246 - JP 2014500723-A/148749: Polycomb-Associated Non-Coding RNAs.
AK300962 - Homo sapiens cDNA FLJ50880 complete cds, highly similar to Proteasome subunit beta type 8 precursor (EC 3.4.25.1).
LF212708 - JP 2014500723-A/20211: Polycomb-Associated Non-Coding RNAs.
JD442347 - Sequence 423371 from Patent EP1572962.
LQ927258 - Sequence 35 from Patent WO2018191660.
MA446372 - JP 2018138019-A/18298: Polycomb-Associated Non-Coding RNAs.
MA576823 - JP 2018138019-A/148749: Polycomb-Associated Non-Coding RNAs.
MA448285 - JP 2018138019-A/20211: Polycomb-Associated Non-Coding RNAs.
MP584544 - Sequence 43 from Patent WO2020081767.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mhcPathway - Antigen Processing and Presentation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000374882.1, ENST00000374882.2, ENST00000374882.3, ENST00000374882.4, ENST00000374882.5, ENST00000374882.6, ENST00000374882.7, NM_148919, PSM8 , uc318lxi.1, uc318lxi.2, X5CMJ9, X5CMJ9_HUMAN
UCSC ID: ENST00000374882.8_8
RefSeq Accession: NM_148919.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.