Human Gene PSMC1 (ENST00000261303.13_4) from GENCODE V47lift37
  Description: proteasome 26S subunit, ATPase 1, transcript variant 1 (from RefSeq NM_002802.3)
Gencode Transcript: ENST00000261303.13_4
Gencode Gene: ENSG00000100764.14_9
Transcript (Including UTRs)
   Position: hg19 chr14:90,722,897-90,741,773 Size: 18,877 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr14:90,722,942-90,738,751 Size: 15,810 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:90,722,897-90,741,773)mRNA (may differ from genome)Protein (440 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53XL8_HUMAN
DESCRIPTION: SubName: Full=Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; SubName: Full=Proteasome (Prosome, macropain) 26S subunit, ATPase, 1, isoform CRA_a; SubName: Full=Proteasome 26S ATPase subunit 1; SubName: Full=cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA;
SIMILARITY: Belongs to the AAA ATPase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.36 RPKM in Testis
Total median expression: 876.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.8045-0.240 Picture PostScript Text
3' UTR -1012.203022-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005937 - 26S_Psome_P45
IPR003593 - AAA+_ATPase
IPR003959 - ATPase_AAA_core
IPR003960 - ATPase_AAA_CS

Pfam Domains:
PF00004 - ATPase family associated with various cellular activities (AAA)
PF05496 - Holliday junction DNA helicase RuvB P-loop domain
PF07724 - AAA domain (Cdc48 subfamily)
PF16450 - Proteasomal ATPase OB C-terminal domain
PF17862 - AAA+ lid domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q53XL8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017025 TBP-class protein binding
GO:0036402 proteasome-activating ATPase activity

Biological Process:
GO:0030163 protein catabolic process
GO:1901215 negative regulation of neuron death
GO:1901800 positive regulation of proteasomal protein catabolic process

Cellular Component:
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0022624 proteasome accessory complex


-  Descriptions from all associated GenBank mRNAs
  L02426 - Human 26S protease (S4) regulatory subunit mRNA, complete cds.
AK313325 - Homo sapiens cDNA, FLJ93843, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1(PSMC1), mRNA.
BC000512 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1, mRNA (cDNA clone MGC:8541 IMAGE:2822718), complete cds.
BC016368 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1, mRNA (cDNA clone MGC:24583 IMAGE:4133348), complete cds.
AK299121 - Homo sapiens cDNA FLJ58247 complete cds, highly similar to 26S protease regulatory subunit 4.
BC067741 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1, mRNA (cDNA clone MGC:86994 IMAGE:5264945), complete cds.
AK222668 - Homo sapiens mRNA for proteasome 26S ATPase subunit 1 variant, clone: CBR03079.
DQ894881 - Synthetic construct Homo sapiens clone IMAGE:100009341; FLH184008.01L; RZPDo839B03143D proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1) gene, encodes complete protein.
DQ891703 - Synthetic construct clone IMAGE:100004333; FLH184012.01X; RZPDo839B03144D proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1) gene, encodes complete protein.
CU677617 - Synthetic construct Homo sapiens gateway clone IMAGE:100017274 5' read PSMC1 mRNA.
CU674244 - Synthetic construct Homo sapiens gateway clone IMAGE:100018296 5' read PSMC1 mRNA.
CU688316 - Synthetic construct Homo sapiens gateway clone IMAGE:100022837 5' read PSMC1 mRNA.
AB451441 - Homo sapiens PSMC1 mRNA for proteasome 26S ATPase subunit 1, partial cds, clone: FLJ08170AAAF.
AB463195 - Synthetic construct DNA, clone: pF1KB3424, Homo sapiens PSMC1 gene for proteasome (prosome, macropain) 26S subunit, ATPase, 1, without stop codon, in Flexi system.
KJ905877 - Synthetic construct Homo sapiens clone ccsbBroadEn_15547 PSMC1 gene, encodes complete protein.
BT009826 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1 mRNA, complete cds.
KJ897408 - Synthetic construct Homo sapiens clone ccsbBroadEn_06802 PSMC1 gene, encodes complete protein.
KJ897409 - Synthetic construct Homo sapiens clone ccsbBroadEn_06803 PSMC1 gene, encodes complete protein.
AB451311 - Homo sapiens PSMC1 mRNA for proteasome 26S ATPase subunit 1, complete cds, clone: FLJ08170AAAN.
CR457044 - Homo sapiens full open reading frame cDNA clone RZPDo834C0318D for gene PSMC1, proteasome (prosome, macropain) 26S subunit, ATPase, 1; complete cds, incl. stopcodon.
BC018859 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1, mRNA (cDNA clone IMAGE:3141213).
BC073818 - Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 1, mRNA (cDNA clone MGC:88853 IMAGE:5456334), complete cds.
LF345492 - JP 2014500723-A/152995: Polycomb-Associated Non-Coding RNAs.
LF345493 - JP 2014500723-A/152996: Polycomb-Associated Non-Coding RNAs.
DQ185033 - Homo sapiens proteasome 26S subunit ATPase 1-like mRNA, partial sequence.
AK124201 - Homo sapiens cDNA FLJ42207 fis, clone THYMU2036207, highly similar to Mus musculus protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1).
LF345495 - JP 2014500723-A/152998: Polycomb-Associated Non-Coding RNAs.
LF345496 - JP 2014500723-A/152999: Polycomb-Associated Non-Coding RNAs.
JD480631 - Sequence 461655 from Patent EP1572962.
JD039132 - Sequence 20156 from Patent EP1572962.
JD181468 - Sequence 162492 from Patent EP1572962.
JD456852 - Sequence 437876 from Patent EP1572962.
AF401213 - Homo sapiens 26S protease regulatory subunit (PSMC1) mRNA, 3' untranslated region.
JD554512 - Sequence 535536 from Patent EP1572962.
JD208704 - Sequence 189728 from Patent EP1572962.
JD472385 - Sequence 453409 from Patent EP1572962.
MA581069 - JP 2018138019-A/152995: Polycomb-Associated Non-Coding RNAs.
MA581070 - JP 2018138019-A/152996: Polycomb-Associated Non-Coding RNAs.
MA581072 - JP 2018138019-A/152998: Polycomb-Associated Non-Coding RNAs.
MA581073 - JP 2018138019-A/152999: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261303.1, ENST00000261303.10, ENST00000261303.11, ENST00000261303.12, ENST00000261303.2, ENST00000261303.3, ENST00000261303.4, ENST00000261303.5, ENST00000261303.6, ENST00000261303.7, ENST00000261303.8, ENST00000261303.9, hCG_2029049 , NM_002802, PSMC1 , Q53XL8, Q53XL8_HUMAN, uc317goo.1, uc317goo.2
UCSC ID: ENST00000261303.13_4
RefSeq Accession: NM_002802.3
Protein: Q53XL8

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.