Human Gene PSTPIP2 (ENST00000409746.5_7) from GENCODE V47lift37
  Description: proline-serine-threonine phosphatase interacting protein 2 (from RefSeq NM_024430.4)
Gencode Transcript: ENST00000409746.5_7
Gencode Gene: ENSG00000152229.18_9
Transcript (Including UTRs)
   Position: hg19 chr18:43,563,502-43,652,226 Size: 88,725 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr18:43,568,676-43,652,154 Size: 83,479 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:43,563,502-43,652,226)mRNA (may differ from genome)Protein (334 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPIP2_HUMAN
DESCRIPTION: RecName: Full=Proline-serine-threonine phosphatase-interacting protein 2; Short=PEST phosphatase-interacting protein 2;
FUNCTION: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
PTM: Phosphorylated on tyrosine (By similarity).
SIMILARITY: Contains 1 FCH domain.
SEQUENCE CAUTION: Sequence=BAB14404.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.70 RPKM in Spleen
Total median expression: 214.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.7072-0.288 Picture PostScript Text
3' UTR -541.001923-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001060 - FCH

Pfam Domains:
PF00611 - Fes/CIP4, and EFC/F-BAR homology domain

SCOP Domains:
103657 - BAR/IMD domain-like

ModBase Predicted Comparative 3D Structure on Q9H939
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding

Biological Process:
GO:0007010 cytoskeleton organization
GO:0016477 cell migration

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC035395 - Homo sapiens proline-serine-threonine phosphatase interacting protein 2, mRNA (cDNA clone MGC:34175 IMAGE:4524856), complete cds.
DQ893199 - Synthetic construct clone IMAGE:100005829; FLH195179.01X; RZPDo839E0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
DQ893200 - Synthetic construct clone IMAGE:100005830; FLH195180.01X; RZPDo839F0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
DQ893201 - Synthetic construct clone IMAGE:100005831; FLH195181.01X; RZPDo839G0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
DQ893695 - Synthetic construct clone IMAGE:100006325; FLH195182.01X; RZPDo839H0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
KJ904616 - Synthetic construct Homo sapiens clone ccsbBroadEn_14010 PSTPIP2 gene, encodes complete protein.
DQ896527 - Synthetic construct Homo sapiens clone IMAGE:100010987; FLH195176.01L; RZPDo839B0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
DQ896528 - Synthetic construct Homo sapiens clone IMAGE:100010988; FLH195177.01L; RZPDo839C0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
DQ896529 - Synthetic construct Homo sapiens clone IMAGE:100010989; FLH195178.01L; RZPDo839D0684D proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) gene, encodes complete protein.
KU178455 - Homo sapiens proline-serine-threonine phosphatase interacting protein 2 isoform 1 (PSTPIP2) mRNA, partial cds, alternatively spliced.
KU178456 - Homo sapiens proline-serine-threonine phosphatase interacting protein 2 isoform 2 (PSTPIP2) mRNA, complete cds.
KU178457 - Homo sapiens proline-serine-threonine phosphatase interacting protein 2 isoform 3 (PSTPIP2) mRNA, complete cds, alternatively spliced.
BC026223 - Homo sapiens, proline-serine-threonine phosphatase interacting protein 2, clone IMAGE:4399480, mRNA.
AK023100 - Homo sapiens cDNA FLJ13038 fis, clone NT2RP3001272, weakly similar to Mus musculus mRNA for macrophage actin-associated-tyrosine-phosphorylated protein.
JD222284 - Sequence 203308 from Patent EP1572962.
JD530613 - Sequence 511637 from Patent EP1572962.
JD161259 - Sequence 142283 from Patent EP1572962.
JD153180 - Sequence 134204 from Patent EP1572962.
JD259724 - Sequence 240748 from Patent EP1572962.
JD418929 - Sequence 399953 from Patent EP1572962.
JD418827 - Sequence 399851 from Patent EP1572962.
JD049237 - Sequence 30261 from Patent EP1572962.
JD433134 - Sequence 414158 from Patent EP1572962.
JD522029 - Sequence 503053 from Patent EP1572962.
JD564826 - Sequence 545850 from Patent EP1572962.
JD042103 - Sequence 23127 from Patent EP1572962.
JD244269 - Sequence 225293 from Patent EP1572962.
JD283638 - Sequence 264662 from Patent EP1572962.
JD296501 - Sequence 277525 from Patent EP1572962.
JD300759 - Sequence 281783 from Patent EP1572962.
JD449370 - Sequence 430394 from Patent EP1572962.
JD316581 - Sequence 297605 from Patent EP1572962.
JD100750 - Sequence 81774 from Patent EP1572962.
JD326962 - Sequence 307986 from Patent EP1572962.
JD101568 - Sequence 82592 from Patent EP1572962.
JD212138 - Sequence 193162 from Patent EP1572962.
JD073305 - Sequence 54329 from Patent EP1572962.
JD520609 - Sequence 501633 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000409746.1, ENST00000409746.2, ENST00000409746.3, ENST00000409746.4, NM_024430, PPIP2_HUMAN, Q9H939, uc319gcx.1, uc319gcx.2
UCSC ID: ENST00000409746.5_7
RefSeq Accession: NM_024430.4
Protein: Q9H939 (aka PPIP2_HUMAN or PSP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.