The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16647
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0005515 protein binding GO:0008116 prostaglandin-I synthase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016853 isomerase activity GO:0020037 heme binding GO:0046872 metal ion binding
Biological Process: GO:0001516 prostaglandin biosynthetic process GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0007566 embryo implantation GO:0019371 cyclooxygenase pathway GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0045766 positive regulation of angiogenesis GO:0046697 decidualization GO:0050728 negative regulation of inflammatory response GO:0055114 oxidation-reduction process GO:0071347 cellular response to interleukin-1 GO:0071354 cellular response to interleukin-6 GO:0071456 cellular response to hypoxia GO:0097190 apoptotic signaling pathway GO:1900119 positive regulation of execution phase of apoptosis
BioCarta from NCI Cancer Genome Anatomy Project h_eicosanoidPathway - Eicosanoid Metabolism
Reactome (by CSHL, EBI, and GO)
Protein Q16647 (Reactome details) participates in the following event(s):
R-HSA-76496 PTGIS, CYP8A1 isomerise PGH2 to PGI2 R-HSA-192157 CYP8B1 12-hydroxylates 4CHOL7aOLONE R-HSA-193709 CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL R-HSA-193845 CYP8B1 12-hydroxylates 4CHOL7a,27DONE R-HSA-197264 Nicotinamide salvaging R-HSA-211979 Eicosanoids R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-196807 Nicotinate metabolism R-HSA-211897 Cytochrome P450 - arranged by substrate type R-HSA-2142753 Arachidonic acid metabolism R-HSA-192105 Synthesis of bile acids and bile salts R-HSA-211976 Endogenous sterols R-HSA-196849 Metabolism of water-soluble vitamins and cofactors R-HSA-211945 Phase I - Functionalization of compounds R-HSA-8978868 Fatty acid metabolism R-HSA-194068 Bile acid and bile salt metabolism R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-211859 Biological oxidations R-HSA-556833 Metabolism of lipids R-HSA-8957322 Metabolism of steroids R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
