Human Gene PTH2 (ENST00000270631.2_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: TIP39_HUMAN
DESCRIPTION: RecName: Full=Tuberoinfundibular peptide of 39 residues; Short=TIP39; AltName: Full=Parathyroid hormone 2; Flags: Precursor;
FUNCTION: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
SUBUNIT: Ligand of high affinity for the PTH2 receptor (PTH2R).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.
SIMILARITY: Belongs to the parathyroid hormone family.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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Pfam Domains:
PF14980 - TIP39 peptide
ModBase Predicted Comparative 3D Structure on Q96A98
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component:
GO:0005576 extracellular region
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Descriptions from all associated GenBank mRNAs
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AY037555 - Homo sapiens tuberoinfundibular 39 residue protein precursor (TIP39) mRNA, complete cds.
BC093997 - Homo sapiens parathyroid hormone 2, mRNA (cDNA clone MGC:121032 IMAGE:7939842), complete cds.
BC093995 - Homo sapiens parathyroid hormone 2, mRNA (cDNA clone MGC:121030 IMAGE:7939840), complete cds.
JD157423 - Sequence 138447 from Patent EP1572962.
KJ895244 - Synthetic construct Homo sapiens clone ccsbBroadEn_04638 PTH2 gene, encodes complete protein.
AY048588 - Homo sapiens tuberoinfundibular 39 residue protein precursor (TIP39) mRNA, partial cds.
JD242183 - Sequence 223207 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000270631.1, NM_178449, Q96A98, Q96DJ4, TIP39, TIP39_HUMAN, TIPF39, uc317iut.1, uc317iut.2
UCSC ID: ENST00000270631.2_7
RefSeq Accession: NM_178449.4
Protein: Q96A98
(aka TIP39_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
