Human Gene PTK2 (ENST00000696786.1_5) from GENCODE V47lift37

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Description: protein tyrosine kinase 2, transcript variant 65 (from RefSeq NR_148037.2)
Gencode Transcript: ENST00000696786.1_5
Gencode Gene: ENSG00000169398.20_19
Transcript (Including UTRs)
Position: hg19 chr8:141,667,999-142,011,381 Size: 343,383 Total Exon Count: 36 Strand: -
Coding Region
Position: hg19 chr8:141,669,565-141,900,836 Size: 231,272 Coding Exon Count: 34

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:141,667,999-142,011,381)			mRNA (may differ from genome)		Protein (1096 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PTK2 Diseases sorted by gene-association score: glioblastoma multiforme (5), malignant glioma (5), lung cancer (4), colorectal cancer (4), melanoma (3), mitral valve disease (2), pancreatic cancer (2), cerebral hypoxia (2), hepatocellular carcinoma (2), prostate cancer (2), breast cancer (2), uveal melanoma (2), ovarian cancer, somatic (2), thrombasthenia (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C032881 lysophosphatidic acid D001151 Arsenic D001564 Benzo(a)pyrene D002211 Capsaicin D002945 Cisplatin D004317 Doxorubicin D019833 Genistein D006861 Hydrogen Peroxide D008274 Magnesium C045651 epigallocatechin gallate more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-107.60	279	-0.386	Picture	PostScript	Text
3' UTR	-370.40	1566	-0.237	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Descriptions from all associated GenBank mRNAs


	BC035404 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone MGC:34721 IMAGE:4999680), complete cds. BC028733 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone MGC:33483 IMAGE:4812915), complete cds. AL832961 - Homo sapiens mRNA; cDNA DKFZp666O0110 (from clone DKFZp666O0110). AK094999 - Homo sapiens cDNA FLJ37680 fis, clone BRHIP2012923, highly similar to FOCAL ADHESION KINASE 1 (EC 2.7.1.112). AK304356 - Homo sapiens cDNA FLJ61553 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). AB209083 - Homo sapiens mRNA for PTK2 protein tyrosine kinase 2 isoform b variant protein. AB209071 - Homo sapiens mRNA for PTK2 protein tyrosine kinase 2 isoform b variant protein. L13616 - Human focal adhesion kinase (FAK) mRNA, complete cds. AK301557 - Homo sapiens cDNA FLJ57218 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). L05186 - Homo sapiens focal adhesion kinase mRNA, complete cds. AK294873 - Homo sapiens cDNA FLJ57973 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). KJ904540 - Synthetic construct Homo sapiens clone ccsbBroadEn_13934 PTK2 gene, encodes complete protein. KF437463 - Homo sapiens focal adhesion kinase isoform FAK-Del33 (FAK) mRNA, complete cds, alternatively spliced. EU176794 - Synthetic construct Homo sapiens clone IMAGE:100011553; FLH195223.01L; RZPDo839A1284D PTK2 protein tyrosine kinase 2 (PTK2) gene, encodes complete protein. BC015361 - Homo sapiens, clone IMAGE:3886095, mRNA. AK124810 - Homo sapiens cDNA FLJ42820 fis, clone BRCAN2015719, highly similar to FOCAL ADHESION KINASE 1 (EC 2.7.1.112). JD055978 - Sequence 37002 from Patent EP1572962. JD503677 - Sequence 484701 from Patent EP1572962. JD516741 - Sequence 497765 from Patent EP1572962. JD280316 - Sequence 261340 from Patent EP1572962. JD202724 - Sequence 183748 from Patent EP1572962. JD530226 - Sequence 511250 from Patent EP1572962. JD110546 - Sequence 91570 from Patent EP1572962. JD523859 - Sequence 504883 from Patent EP1572962. JD441363 - Sequence 422387 from Patent EP1572962. JD138004 - Sequence 119028 from Patent EP1572962. JD273709 - Sequence 254733 from Patent EP1572962. AK055139 - Homo sapiens cDNA FLJ30577 fis, clone BRAWH2006760. BC043202 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone IMAGE:5294745). JD056228 - Sequence 37252 from Patent EP1572962. JD057274 - Sequence 38298 from Patent EP1572962. JD406055 - Sequence 387079 from Patent EP1572962. JD458513 - Sequence 439537 from Patent EP1572962. JD461601 - Sequence 442625 from Patent EP1572962. JD406801 - Sequence 387825 from Patent EP1572962. JD461600 - Sequence 442624 from Patent EP1572962. JD129458 - Sequence 110482 from Patent EP1572962. JD191250 - Sequence 172274 from Patent EP1572962. JD389916 - Sequence 370940 from Patent EP1572962. JD191918 - Sequence 172942 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A8Q3WLM4, A0A8Q3WLM4_HUMAN, NR_148037, PTK2 , uc331bkq.1, uc331bkq.2 UCSC ID: ENST00000696786.1_5 RefSeq Accession: NM_001352702.2

Gene Model Information


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Methods, Credits, and Use Restrictions


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