Human Gene PTK2 (ENST00000696786.1_5) from GENCODE V47lift37

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Description: protein tyrosine kinase 2, transcript variant 65 (from RefSeq NR_148037.2)
Gencode Transcript: ENST00000696786.1_5
Gencode Gene: ENSG00000169398.20_19
Transcript (Including UTRs)
Position: hg19 chr8:141,667,999-142,011,381 Size: 343,383 Total Exon Count: 36 Strand: -
Coding Region
Position: hg19 chr8:141,669,565-141,900,836 Size: 231,272 Coding Exon Count: 34

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:141,667,999-142,011,381)			mRNA (may differ from genome)		Protein (1096 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PTK2 Diseases sorted by gene-association score: glioblastoma multiforme (5), malignant glioma (5), lung cancer (4), colorectal cancer (4), melanoma (3), mitral valve disease (2), pancreatic cancer (2), cerebral hypoxia (2), hepatocellular carcinoma (2), prostate cancer (2), breast cancer (2), uveal melanoma (2), ovarian cancer, somatic (2), thrombasthenia (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C032881 lysophosphatidic acid D001151 Arsenic D001564 Benzo(a)pyrene D002211 Capsaicin D002945 Cisplatin D004317 Doxorubicin D019833 Genistein D006861 Hydrogen Peroxide D008274 Magnesium C045651 epigallocatechin gallate C001277 geldanamycin C014175 pyrazolo(3,4-d)pyrimidine C009687 wortmannin C539551 1,2,4,5-benzenetetraamine C049325 1,2-dithiol-3-thione C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one C436284 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole C011506 2-methyl-4-isothiazolin-3-one C027576 4-hydroxy-2-nonenal C068805 4-hydroxycoumarin D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D015124 8-Bromo Cyclic Adenosine Monophosphate D000082 Acetaminophen D000111 Acetylcysteine D020106 Acrylamide D000537 Aluminum Oxide D000643 Ammonium Chloride D000781 Anethole Trithione D001205 Ascorbic Acid D001285 Atropine C086539 BQ 788 D019328 Buthionine Sulfoximine D002104 Cadmium D002392 Catechin D004390 Chlorpyrifos D060729 Coal Ash D003042 Cocaine D003300 Copper D016578 Crack Cocaine D003474 Curcumin D003609 Dactinomycin D017292 Doxazosin D004726 Endosulfan D004958 Estradiol D004997 Ethinyl Estradiol D005419 Flavonoids D005472 Fluorouracil C062018 HU 211 D006221 Halothane D006493 Heparin D006812 Humic Substances D006820 Hyaluronic Acid D007213 Indomethacin D007649 Ketamine D007854 Lead D008070 Lipopolysaccharides D047311 Luteolin C070571 ML 7 D008353 Mannitol D008748 Methylcholanthrene D018817 N-Methyl-3,4-methylenedioxyamphetamine C093285 NOC 18 D009569 Nitric Oxide D015242 Ofloxacin D010126 Ozone D010705 Phosgene D010862 Pilocarpine D011205 Povidone C527556 Pt(O,O'-acac)(gamma-acac)(DMS) D011692 Puromycin Aminonucleoside D011794 Quercetin D017382 Reactive Oxygen Species D012834 Silver D018030 Silver Compounds D019821 Simvastatin D020123 Sirolimus D018038 Sodium Selenite D013629 Tamoxifen D013739 Testosterone D013749 Tetrachlorodibenzodioxin D013755 Tetradecanoylphorbol Acetate D013849 Thimerosal D014212 Tretinoin D014501 Uranium D014638 Vanadates C011512 alpha-naphthoflavone C517629 benzyloxycarbonyl-valyl-alanyl-aspartic acid C472645 blebbistatin C072247 cyclo(Trp-Asp-Pro-Val-Leu) C004742 daidzein C488369 dasatinib C041517 dibenzo(a,l)pyrene C067311 docetaxel C053629 fluoroaluminum C038958 gadolinium chloride C054597 garcinol C056507 gemcitabine C051890 irinotecan C022838 nickel chloride C029341 oxophenylarsine C042743 oxotremorine M C076994 perfluorooctane sulfonic acid C500434 phenyl caffeate C006253 pirinixic acid C079805 poly(N-isopropylacrylamide-N-tert-butylacrylamide)copolymer C027373 potassium chromate(VI) C059514 resveratrol C089730 rosiglitazone C017947 sodium arsenite C025462 sulindac sulfide C041359 terbinafine D020122 tert-Butylhydroperoxide C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate C020809 tetrathiomolybdate C005460 uranyl acetate C088658 zoledronic acid

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-107.60	279	-0.386	Picture	PostScript	Text
3' UTR	-370.40	1566	-0.237	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Descriptions from all associated GenBank mRNAs


	BC035404 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone MGC:34721 IMAGE:4999680), complete cds. BC028733 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone MGC:33483 IMAGE:4812915), complete cds. AL832961 - Homo sapiens mRNA; cDNA DKFZp666O0110 (from clone DKFZp666O0110). AK094999 - Homo sapiens cDNA FLJ37680 fis, clone BRHIP2012923, highly similar to FOCAL ADHESION KINASE 1 (EC 2.7.1.112). AK304356 - Homo sapiens cDNA FLJ61553 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). AB209083 - Homo sapiens mRNA for PTK2 protein tyrosine kinase 2 isoform b variant protein. AB209071 - Homo sapiens mRNA for PTK2 protein tyrosine kinase 2 isoform b variant protein. L13616 - Human focal adhesion kinase (FAK) mRNA, complete cds. AK301557 - Homo sapiens cDNA FLJ57218 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). L05186 - Homo sapiens focal adhesion kinase mRNA, complete cds. AK294873 - Homo sapiens cDNA FLJ57973 complete cds, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2). KJ904540 - Synthetic construct Homo sapiens clone ccsbBroadEn_13934 PTK2 gene, encodes complete protein. KF437463 - Homo sapiens focal adhesion kinase isoform FAK-Del33 (FAK) mRNA, complete cds, alternatively spliced. EU176794 - Synthetic construct Homo sapiens clone IMAGE:100011553; FLH195223.01L; RZPDo839A1284D PTK2 protein tyrosine kinase 2 (PTK2) gene, encodes complete protein. BC015361 - Homo sapiens, clone IMAGE:3886095, mRNA. AK124810 - Homo sapiens cDNA FLJ42820 fis, clone BRCAN2015719, highly similar to FOCAL ADHESION KINASE 1 (EC 2.7.1.112). JD055978 - Sequence 37002 from Patent EP1572962. JD503677 - Sequence 484701 from Patent EP1572962. JD516741 - Sequence 497765 from Patent EP1572962. JD280316 - Sequence 261340 from Patent EP1572962. JD202724 - Sequence 183748 from Patent EP1572962. JD530226 - Sequence 511250 from Patent EP1572962. JD110546 - Sequence 91570 from Patent EP1572962. JD523859 - Sequence 504883 from Patent EP1572962. JD441363 - Sequence 422387 from Patent EP1572962. JD138004 - Sequence 119028 from Patent EP1572962. JD273709 - Sequence 254733 from Patent EP1572962. AK055139 - Homo sapiens cDNA FLJ30577 fis, clone BRAWH2006760. BC043202 - Homo sapiens PTK2 protein tyrosine kinase 2, mRNA (cDNA clone IMAGE:5294745). JD056228 - Sequence 37252 from Patent EP1572962. JD057274 - Sequence 38298 from Patent EP1572962. JD406055 - Sequence 387079 from Patent EP1572962. JD458513 - Sequence 439537 from Patent EP1572962. JD461601 - Sequence 442625 from Patent EP1572962. JD406801 - Sequence 387825 from Patent EP1572962. JD461600 - Sequence 442624 from Patent EP1572962. JD129458 - Sequence 110482 from Patent EP1572962. JD191250 - Sequence 172274 from Patent EP1572962. JD389916 - Sequence 370940 from Patent EP1572962. JD191918 - Sequence 172942 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A8Q3WLM4, A0A8Q3WLM4_HUMAN, NR_148037, PTK2 , uc331bkq.1, uc331bkq.2 UCSC ID: ENST00000696786.1_5 RefSeq Accession: NM_001352702.2

Gene Model Information


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Methods, Credits, and Use Restrictions


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