Human Gene PTMA (ENST00000409115.8_8) from GENCODE V47lift37
  Description: prothymosin alpha, transcript variant 2 (from RefSeq NM_002823.5)
Gencode Transcript: ENST00000409115.8_8
Gencode Gene: ENSG00000187514.17_17
Transcript (Including UTRs)
   Position: hg19 chr2:232,573,235-232,578,261 Size: 5,027 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr2:232,573,417-232,577,561 Size: 4,145 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:232,573,235-232,578,261)mRNA (may differ from genome)Protein (110 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTMA
Diseases sorted by gene-association score: hepatitis b (5), invasive malignant thymoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 807.59 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 13448.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.80182-0.274 Picture PostScript Text
3' UTR -164.50700-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004931 - Pro/parathymosin

Pfam Domains:
PF03247 - Prothymosin/parathymosin family

ModBase Predicted Comparative 3D Structure on Q53S24
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC022433 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:24712 IMAGE:4277490), complete cds.
AK314106 - Homo sapiens cDNA, FLJ94794, highly similar to Homo sapiens prothymosin, alpha (gene sequence 28) (PTMA), mRNA.
M14630 - Human prothymosin alpha mRNA, complete cds.
AK223605 - Homo sapiens mRNA for prothymosin, alpha (gene sequence 28) variant, clone: FCC132D11.
BC034921 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:45641 IMAGE:4335961), complete cds.
BC098420 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:104802 IMAGE:5017164), complete cds.
BC001624 - Homo sapiens prothymosin, alpha (gene sequence 28), mRNA (cDNA clone IMAGE:3357953), **** WARNING: chimeric clone ****.
BC070480 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:87813 IMAGE:6205582), complete cds.
BC051265 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:59657 IMAGE:3832454), complete cds.
BC003510 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:10549 IMAGE:3610808), complete cds.
BC071879 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:88552 IMAGE:6425103), complete cds.
BC071647 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:87812 IMAGE:5112610), complete cds.
JD386343 - Sequence 367367 from Patent EP1572962.
M26708 - Human prothymosin alpha mRNA (ProT-alpha), complete cds.
JD151489 - Sequence 132513 from Patent EP1572962.
M14483 - Human prothymosin alpha mRNA, complete cds.
BC066905 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone MGC:87078 IMAGE:4830132), complete cds.
JD458572 - Sequence 439596 from Patent EP1572962.
JD563848 - Sequence 544872 from Patent EP1572962.
M14794 - Human prothymosin alpha mRNA, lymphocyte clone pIF536.
JD079757 - Sequence 60781 from Patent EP1572962.
JD392395 - Sequence 373419 from Patent EP1572962.
JD134839 - Sequence 115863 from Patent EP1572962.
JD206730 - Sequence 187754 from Patent EP1572962.
JD099222 - Sequence 80246 from Patent EP1572962.
JD270634 - Sequence 251658 from Patent EP1572962.
JD270633 - Sequence 251657 from Patent EP1572962.
DQ896210 - Synthetic construct Homo sapiens clone IMAGE:100010670; FLH191207.01L; RZPDo839A1067D prothymosin, alpha (gene sequence 28) (PTMA) gene, encodes complete protein.
DQ892963 - Synthetic construct clone IMAGE:100005593; FLH191211.01X; RZPDo839A1077D prothymosin, alpha (gene sequence 28) (PTMA) gene, encodes complete protein.
KJ905883 - Synthetic construct Homo sapiens clone ccsbBroadEn_15553 PTMA gene, encodes complete protein.
KJ891945 - Synthetic construct Homo sapiens clone ccsbBroadEn_01339 PTMA gene, encodes complete protein.
AF348514 - Homo sapiens fetal thymus prothymosin alpha mRNA, complete cds.
AY169282 - Homo sapiens prothymosin alpha protein mRNA, complete cds.
AF452640 - Homo sapiens tissue-type testis hypothetical protein mRNA, complete cds.
BX647606 - Homo sapiens mRNA; cDNA DKFZp686G0115 (from clone DKFZp686G0115).
BC005228 - Homo sapiens cDNA clone IMAGE:3680553, **** WARNING: chimeric clone ****.
JD075879 - Sequence 56903 from Patent EP1572962.
JD064257 - Sequence 45281 from Patent EP1572962.
JD057361 - Sequence 38385 from Patent EP1572962.
JD406894 - Sequence 387918 from Patent EP1572962.
BC013859 - Homo sapiens prothymosin, alpha, mRNA (cDNA clone IMAGE:3918065).
JD259728 - Sequence 240752 from Patent EP1572962.
JD500929 - Sequence 481953 from Patent EP1572962.
JD495405 - Sequence 476429 from Patent EP1572962.
HZ408837 - JP 2015528002-A/1434: CHIRAL CONTROL.
HZ408838 - JP 2015528002-A/1435: CHIRAL CONTROL.
HZ408839 - JP 2015528002-A/1436: CHIRAL CONTROL.
LG052171 - KR 1020150036642-A/1437: CHIRAL CONTROL.
LG052172 - KR 1020150036642-A/1438: CHIRAL CONTROL.
LG052173 - KR 1020150036642-A/1439: CHIRAL CONTROL.
HI965542 - Sequence 827 from Patent WO2010139812.
HI965738 - Sequence 58 from Patent WO2010139811.
HI966604 - Sequence 58 from Patent WO2010139810.
HV594790 - JP 2010539959-A/171: Micromirs.
HW913260 - JP 2015504307-A/20: METHODS OF DIAGNOSING AND TREATING IDIOPATHIC PULMONARY FIBROSIS.
HW915050 - JP 2015504655-A/8: METHODS FOR DIAGNOSIS AND THERAPEUTIC FOLLOW-UP OF MUSCULAR DYSTROPHIES.
HZ074692 - JP 2013535982-A/783: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
HZ082983 - JP 2015513906-A/340: Stem Cell Microparticles.
HZ157347 - JP 2015130862-A/171: Micromirs.
HZ436764 - JP 2015529450-A/340: Stem Cell Microparticles.
HZ479677 - JP 2015535430-A/183: TERMINALLY MODIFIED RNA.
HZ789608 - JP 2016504050-A/1353: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JA401580 - Sequence 827 from Patent WO2011080318.
JA402558 - Sequence 827 from Patent WO2011080315.
JA403565 - Sequence 827 from Patent WO2011080316.
JA406196 - Sequence 827 from Patent EP2336353.
JA426907 - Sequence 240 from Patent WO2011072177.
JA429722 - Sequence 827 from Patent WO2011095623.
JB022400 - Sequence 242 from Patent WO2013026685.
JB023206 - Sequence 460 from Patent WO2013026684.
JB175279 - Sequence 311 from Patent WO2012101219.
JB620877 - Sequence 857 from Patent WO2013063544.
JB751126 - Sequence 8 from Patent WO2013087907.
JB778641 - Sequence 20 from Patent WO2013078283.
JC017594 - Sequence 32 from Patent WO2013093870.
JC171968 - Sequence 340 from Patent WO2013150303.
JC512340 - Sequence 2593 from Patent WO2014113089.
JC572779 - Sequence 340 from Patent WO2014125276.
JC582467 - Sequence 340 from Patent WO2014125277.
JE954163 - Sequence 340 from Patent WO2015052526.
JE955916 - Sequence 340 from Patent WO2015052527.
LF137668 - JP 2016507550-A/340: Method of Producing Microparticles.
LF160876 - JP 2016513950-A/942: Oligomers with improved off-target profile.
LF162633 - JP 2016513095-A/340: Stem Cell Microparticles and miRNA.
LF401888 - JP 2015502976-A/32: MICRORNAS FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION.
LF953385 - JP 2016534103-A/340: Stem Cell Microparticles and miRNA.
LG005730 - KR 1020150004822-A/340: STEM CELL MICROPARTICLES.
LG053426 - KR 1020150059168-A/340: STEM CELL MICROPARTICLES.
LG240665 - KR 1020160035087-A/340: STEM CELL MICROPARTICLES AND MIRNA.
LP726364 - Sequence 58 from Patent EP2883966.
LP818634 - Sequence 58 from Patent EP3296406.
LP938576 - Sequence 58 from Patent EP3184651.
LQ069928 - Sequence 252 from Patent EP2964234.
LV470750 - JP 2016534036-A/340: Stem Cell Microparticles and miRNA.
LY404855 - KR 1020160117535-A/160: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
LZ231645 - JP 2017186339-A/32: MICRORNAS FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION.
MA260094 - JP 2017505623-A/160: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MS673657 - Sequence 460 from Patent EP3135774.
MS834681 - Sequence 827 from Patent EP3112479.
MS901769 - Sequence 242 from Patent EP3156505.
MA643429 - JP 2017113010-A/1353: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA731313 - JP 2017140048-A/183: TERMINALLY MODIFIED RNA.
MA800482 - JP 2018183181-A/1353: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MP129440 - Sequence 340 from Patent EP3470073.
MP162363 - Sequence 340 from Patent WO2019069093.
LY648323 - KR 1020190009674-A/2: miR494 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY649606 - KR 1020190009675-A/2: miR1244 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY649615 - KR 1020190009676-A/2: miR6768 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY649624 - KR 1020190009677-A/2: miR4324 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY649633 - KR 1020190009678-A/2: miR4726 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY649642 - KR 1020190009679-A/2: miR501 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY663926 - KR 1020190009722-A/2: miR1226 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY663935 - KR 1020190009723-A/2: miR4767 as a biomarker for parkinson's disease and diagnostic kit using thereof.
LY663944 - KR 1020190009724-A/2: miR3064 as a biomarker for parkinson's disease and diagnostic kit using thereof.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000409115.1, ENST00000409115.2, ENST00000409115.3, ENST00000409115.4, ENST00000409115.5, ENST00000409115.6, ENST00000409115.7, NM_002823, PTMA , PTMAP7 , Q53S24, Q53S24_HUMAN, uc319fht.1, uc319fht.2
UCSC ID: ENST00000409115.8_8
RefSeq Accession: NM_002823.5
Protein: Q53S24

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.