ID:HACD3_HUMAN DESCRIPTION: RecName: Full=Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3; EC=4.2.1.134; AltName: Full=3-hydroxyacyl-CoA dehydratase 3; Short=HACD3; AltName: Full=Butyrate-induced protein 1; Short=B-ind1; Short=hB-ind1; AltName: Full=Protein tyrosine phosphatase-like protein PTPLAD1; AltName: Full=Protein-tyrosine phosphatase-like A domain-containing protein 1; FUNCTION: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression. CATALYTIC ACTIVITY: A very-long-chain (3R)-3-hydroxyacyl-[acyl- carrier protein] = a very-long-chain trans-2,3-dehydroacyl-[acyl- carrier protein] + H(2)O. SUBUNIT: Interacts with the condensation enzymes of the ELOVL family. Interacts with RAC1. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. INDUCTION: By AKAP12 and histone deacetylase inhibitors such as sodium butyrate. SIMILARITY: Belongs to the very long-chain fatty acids dehydratase HACD family. SIMILARITY: Contains 1 CS domain. SEQUENCE CAUTION: Sequence=AAF29085.1; Type=Frameshift; Positions=356; Sequence=BAC11249.1; Type=Frameshift; Positions=359;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 49764 - HSP20-like chaperones 81406 - Mitochondrial cytochrome c oxidase subunit IV
ModBase Predicted Comparative 3D Structure on Q9P035
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0007264 small GTPase mediated signal transduction GO:0007266 Rho protein signal transduction GO:0016601 Rac protein signal transduction GO:0030148 sphingolipid biosynthetic process GO:0030497 fatty acid elongation GO:0042761 very long-chain fatty acid biosynthetic process GO:0043547 positive regulation of GTPase activity GO:0045070 positive regulation of viral genome replication GO:0046726 positive regulation by virus of viral protein levels in host cell
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
