ID:PTPM1_HUMAN DESCRIPTION: RecName: Full=Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; EC=3.1.3.27; AltName: Full=PTEN-like phosphatase; AltName: Full=Phosphoinositide lipid phosphatase; AltName: Full=Protein-tyrosine phosphatase mitochondrial 1; EC=3.1.3.16; EC=3.1.3.48; Flags: Precursor; FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). CATALYTIC ACTIVITY: Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity). Note=Associated with the inner membrane (By similarity). SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. CAUTION: Was originally erroneously termed DUSP23. SEQUENCE CAUTION: Sequence=AAH14048.1; Type=Erroneous initiation; Sequence=AAK07545.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52799 - (Phosphotyrosine protein) phosphatases II
ModBase Predicted Comparative 3D Structure on Q8WUK0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
