ID:PTN1_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein phosphatase non-receptor type 1; EC=3.1.3.48; AltName: Full=Protein-tyrosine phosphatase 1B; Short=PTP-1B; FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. INTERACTION: P15116:Cdh2 (xeno); NbExp=3; IntAct=EBI-968788, EBI-397974; P10912:GHR; NbExp=5; IntAct=EBI-968788, EBI-286316; P63166:Sumo1 (xeno); NbExp=2; IntAct=EBI-968788, EBI-80152; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane. PTM: Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. PTM: Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. PTM: S-nitrosylation of Cys-215 inactivates the enzyme activity. PTM: Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18031
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006470 protein dephosphorylation GO:0006987 activation of signaling protein activity involved in unfolded protein response GO:0007257 activation of JUN kinase activity GO:0008286 insulin receptor signaling pathway GO:0009966 regulation of signal transduction GO:0009968 negative regulation of signal transduction GO:0016311 dephosphorylation GO:0030100 regulation of endocytosis GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030968 endoplasmic reticulum unfolded protein response GO:0031532 actin cytoskeleton reorganization GO:0033157 regulation of intracellular protein transport GO:0034976 response to endoplasmic reticulum stress GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035791 platelet-derived growth factor receptor-beta signaling pathway GO:0036498 IRE1-mediated unfolded protein response GO:0043407 negative regulation of MAP kinase activity GO:0046626 regulation of insulin receptor signaling pathway GO:0046627 negative regulation of insulin receptor signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway GO:0061098 positive regulation of protein tyrosine kinase activity GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903896 positive regulation of IRE1-mediated unfolded protein response GO:1903898 negative regulation of PERK-mediated unfolded protein response GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:2000646 positive regulation of receptor catabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
