ID:PTN13_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein phosphatase non-receptor type 13; EC=3.1.3.48; AltName: Full=Fas-associated protein-tyrosine phosphatase 1; Short=FAP-1; AltName: Full=PTP-BAS; AltName: Full=Protein-tyrosine phosphatase 1E; Short=PTP-E1; Short=hPTPE1; AltName: Full=Protein-tyrosine phosphatase PTPL1; FUNCTION: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus). INTERACTION: Q9BUL8:PDCD10; NbExp=3; IntAct=EBI-355227, EBI-740195; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. TISSUE SPECIFICITY: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 KIND domain. SIMILARITY: Contains 5 PDZ (DHR) domains. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. SEQUENCE CAUTION: Sequence=AAH39610.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTPN13ID41912ch4q21.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00102 - Protein-tyrosine phosphatase PF00373 - FERM central domain PF00595 - PDZ domain PF09379 - FERM N-terminal domain PF09380 - FERM C-terminal PH-like domain PF16599 - Unstructured linker region on PTN13 protein between PDZ PF17820 - PDZ domain
SCOP Domains: 47031 - Second domain of FERM 50156 - PDZ domain-like 50729 - PH domain-like 52799 - (Phosphotyrosine protein) phosphatases II 56112 - Protein kinase-like (PK-like) 54236 - Ubiquitin-like
ModBase Predicted Comparative 3D Structure on Q12923
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
