ID:PTN14_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein phosphatase non-receptor type 14; EC=3.1.3.48; AltName: Full=Protein-tyrosine phosphatase pez; FUNCTION: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). TISSUE SPECIFICITY: Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15678
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
