ID:PTPRZ_HUMAN DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase zeta; Short=R-PTP-zeta; EC=3.1.3.48; AltName: Full=Protein-tyrosine phosphatase receptor type Z polypeptide 1; AltName: Full=Protein-tyrosine phosphatase receptor type Z polypeptide 2; AltName: Full=R-PTP-zeta-2; Flags: Precursor; FUNCTION: May be involved in the regulation of specific developmental processes in the CNS. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: The carbonic-anhydrase like domain binds to contactin (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. SIMILARITY: Contains 1 alpha-carbonic anhydrase domain. SIMILARITY: Contains 1 fibronectin type-III domain. SIMILARITY: Contains 2 tyrosine-protein phosphatase domains. CAUTION: Was termed (PubMed:8387522 and PubMed:2170109) RPTPase beta. CAUTION: The human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (on chr 7) and PTPRZ2 (on chr 1). However, PTPRZ2 probably does not exist and corresponds to PTPRZ1. SEQUENCE CAUTION: Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23471
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
