ID:PTH2_HUMAN DESCRIPTION: RecName: Full=Peptidyl-tRNA hydrolase 2, mitochondrial; Short=PTH 2; EC=3.1.1.29; AltName: Full=Bcl-2 inhibitor of transcription 1; Flags: Precursor; FUNCTION: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity). FUNCTION: Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N- substituted amino acid + tRNA. SUBUNIT: Monomer. INTERACTION: Q05397:PTK2; NbExp=2; IntAct=EBI-1056751, EBI-702142; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the PTH2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y3E5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
