Human Gene PYROXD2 (ENST00000370575.5_7) from GENCODE V47lift37
  Description: pyridine nucleotide-disulphide oxidoreductase domain 2 (from RefSeq NM_032709.3)
Gencode Transcript: ENST00000370575.5_7
Gencode Gene: ENSG00000119943.13_11
Transcript (Including UTRs)
   Position: hg19 chr10:100,143,325-100,174,939 Size: 31,615 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr10:100,143,555-100,174,892 Size: 31,338 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:100,143,325-100,174,939)mRNA (may differ from genome)Protein (581 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PYRD2_HUMAN
DESCRIPTION: RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; EC=1.-.-.-;
FUNCTION: Probable oxidoreductase (By similarity).
SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.94 RPKM in Adrenal Gland
Total median expression: 188.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.0047-0.298 Picture PostScript Text
3' UTR -49.60230-0.216 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01593 - Flavin containing amine oxidoreductase
PF13450 - NAD(P)-binding Rossmann-like domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
52440 - PreATP-grasp domain
51971 - Nucleotide-binding domain
51984 - MurCD N-terminal domain

ModBase Predicted Comparative 3D Structure on Q8N2H3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AF461898 - Homo sapiens FP3420 mRNA, complete cds.
AK074429 - Homo sapiens cDNA FLJ23849 fis, clone KAT11095.
AK123713 - Homo sapiens cDNA FLJ41719 fis, clone HLUNG2013204, moderately similar to Phytoene dehydrogenase-like.
BC006131 - Homo sapiens chromosome 10 open reading frame 33, mRNA (cDNA clone MGC:13047 IMAGE:3626506), complete cds.
BC035712 - Homo sapiens chromosome 10 open reading frame 33, mRNA (cDNA clone IMAGE:5587702), with apparent retained intron.
BC050574 - Homo sapiens chromosome 10 open reading frame 33, mRNA (cDNA clone IMAGE:5587655), containing frame-shift errors.
AK225637 - Homo sapiens mRNA for hypothetical protein LOC84795 variant, clone: STM00433.
AK075265 - Homo sapiens cDNA FLJ90784 fis, clone THYRO1001456.
JD229331 - Sequence 210355 from Patent EP1572962.
JD372172 - Sequence 353196 from Patent EP1572962.
JD531053 - Sequence 512077 from Patent EP1572962.
JD192551 - Sequence 173575 from Patent EP1572962.
KJ899829 - Synthetic construct Homo sapiens clone ccsbBroadEn_09223 PYROXD2 gene, encodes complete protein.
DQ893418 - Synthetic construct clone IMAGE:100006048; FLH199499.01X; RZPDo839E0782D chromosome 10 open reading frame 33 (C10orf33) gene, encodes complete protein.
DQ896787 - Synthetic construct Homo sapiens clone IMAGE:100011247; FLH199405.01L; RZPDo839E0781D chromosome 10 open reading frame 33 (C10orf33) gene, encodes complete protein.
AK022259 - Homo sapiens cDNA FLJ12197 fis, clone MAMMA1000875.
CU675263 - Synthetic construct Homo sapiens gateway clone IMAGE:100018367 5' read C10orf33 mRNA.
AK295699 - Homo sapiens cDNA FLJ58845 complete cds, highly similar to Probable oxidoreductase C10orf33 (EC 1.-.-.-).
HZ408895 - JP 2015528002-A/1492: CHIRAL CONTROL.
LG052229 - KR 1020150036642-A/1495: CHIRAL CONTROL.
HI965487 - Sequence 772 from Patent WO2010139812.
HI965860 - Sequence 180 from Patent WO2010139811.
HI966726 - Sequence 180 from Patent WO2010139810.
HV594845 - JP 2010539959-A/226: Micromirs.
HW413643 - WO 2014003053-A/92: Method for screening pancreatic cancer and test kit therefor.
HZ074675 - JP 2013535982-A/766: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
HZ083158 - JP 2015513906-A/515: Stem Cell Microparticles.
HZ157402 - JP 2015130862-A/226: Micromirs.
HZ436939 - JP 2015529450-A/515: Stem Cell Microparticles.
HZ479745 - JP 2015535430-A/251: TERMINALLY MODIFIED RNA.
HZ789676 - JP 2016504050-A/1421: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JA401525 - Sequence 772 from Patent WO2011080318.
JA402503 - Sequence 772 from Patent WO2011080315.
JA403510 - Sequence 772 from Patent WO2011080316.
JA406141 - Sequence 772 from Patent EP2336353.
JA429667 - Sequence 772 from Patent WO2011095623.
JA757968 - Sequence 101 from Patent WO2012010584.
JB049994 - Sequence 81 from Patent WO2013020926.
JB620860 - Sequence 840 from Patent WO2013063544.
JC172143 - Sequence 515 from Patent WO2013150303.
JC512408 - Sequence 2661 from Patent WO2014113089.
JC572954 - Sequence 515 from Patent WO2014125276.
JC582642 - Sequence 515 from Patent WO2014125277.
JE954338 - Sequence 515 from Patent WO2015052526.
JE956091 - Sequence 515 from Patent WO2015052527.
LF137843 - JP 2016507550-A/515: Method of Producing Microparticles.
LF160219 - JP 2016513950-A/285: Oligomers with improved off-target profile.
LF162808 - JP 2016513095-A/515: Stem Cell Microparticles and miRNA.
LF636390 - JP 2016519076-A/164: COMBINATION CANCER TREATMENTS UTILIZING MICRORNA AND EGFR-TKI INHIBITORS.
LF644469 - JP 2016144439-A/60: Method for assessing cell aging.
LF953560 - JP 2016534103-A/515: Stem Cell Microparticles and miRNA.
LG005905 - KR 1020150004822-A/515: STEM CELL MICROPARTICLES.
LG053601 - KR 1020150059168-A/515: STEM CELL MICROPARTICLES.
LG134547 - KR 1020150131312-A/165: COMBINATION CANCER TREATMENTS UTILIZING MICRORNAS AND EGFR-TKI INHIBITORS.
LG240840 - KR 1020160035087-A/515: STEM CELL MICROPARTICLES AND MIRNA.
LP715494 - Sequence 15 from Patent WO2016001030.
LP726486 - Sequence 180 from Patent EP2883966.
LP818756 - Sequence 180 from Patent EP3296406.
LP938698 - Sequence 180 from Patent EP3184651.
LP952266 - Sequence 32 from Patent WO2017157593.
LQ069996 - Sequence 320 from Patent EP2964234.
LQ724468 - Sequence 101 from Patent WO2018096084.
LV470925 - JP 2016534036-A/515: Stem Cell Microparticles and miRNA.
LY404910 - KR 1020160117535-A/215: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MA260149 - JP 2017505623-A/215: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MS834626 - Sequence 772 from Patent EP3112479.
AK123386 - Homo sapiens cDNA FLJ41392 fis, clone BRCAN2025712.
JD387663 - Sequence 368687 from Patent EP1572962.
MA643497 - JP 2017113010-A/1421: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA731381 - JP 2017140048-A/251: TERMINALLY MODIFIED RNA.
MP015175 - Sequence 378 from Patent WO2019016252.
MA800550 - JP 2018183181-A/1421: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MP129615 - Sequence 515 from Patent EP3470073.
MP162538 - Sequence 515 from Patent WO2019069093.
MP272126 - Sequence 74 from Patent WO2019157381.
LY624094 - KR 1020180128443-A/32: MAMMALIAN CELLS FOR PRODUCING A SECRETED PROTEIN.
MB420692 - JP 2019154320-A/60: Method for evaluating cell quality.
MP325459 - Sequence 6 from Patent EP3536789.

-  Other Names for This Gene
  Alternate Gene Symbols: C10orf33, D3DR61, ENST00000370575.1, ENST00000370575.2, ENST00000370575.3, ENST00000370575.4, NM_032709, PYRD2_HUMAN, PYROXD2 , Q5TAA9, Q8N2H3, Q9BRQ1, uc318img.1, uc318img.2
UCSC ID: ENST00000370575.5_7
RefSeq Accession: NM_032709.3
Protein: Q8N2H3 (aka PYRD2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.