Human Gene QRFPR (ENST00000394427.3_7) from GENCODE V47lift37
  Description: pyroglutamylated RFamide peptide receptor (from RefSeq NM_198179.3)
Gencode Transcript: ENST00000394427.3_7
Gencode Gene: ENSG00000186867.11_10
Transcript (Including UTRs)
   Position: hg19 chr4:122,249,797-122,302,173 Size: 52,377 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr4:122,250,469-122,301,802 Size: 51,334 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:122,249,797-122,302,173)mRNA (may differ from genome)Protein (431 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QRFPR_HUMAN
DESCRIPTION: RecName: Full=Pyroglutamylated RFamide peptide receptor; AltName: Full=AQ27; AltName: Full=G-protein coupled receptor 103; AltName: Full=Orexigenic neuropeptide QRFP receptor; AltName: Full=SP9155;
FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAL26488.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.86 RPKM in Brain - Hypothalamus
Total median expression: 4.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -164.10371-0.442 Picture PostScript Text
3' UTR -182.40672-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000611 - NPY_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q96P65
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
GO:0042277 peptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0032870 cellular response to hormone stimulus
GO:1901652 response to peptide

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB109629 - Homo sapiens AQ27 mRNA for QRFP receptor, complete cds.
BC128132 - Homo sapiens G protein-coupled receptor 103, mRNA (cDNA clone IMAGE:40112419).
BC128133 - Homo sapiens pyroglutamylated RFamide peptide receptor, mRNA (cDNA clone MGC:149217 IMAGE:40112420), complete cds.
JF810892 - Homo sapiens pyroglutamylated RFamide peptide receptor (QRFPR) mRNA, complete cds.
AF411117 - Homo sapiens G protein-coupled receptor (GPR103) mRNA, complete cds.
KJ903384 - Synthetic construct Homo sapiens clone ccsbBroadEn_12778 QRFPR gene, encodes complete protein.
AB528027 - Synthetic construct DNA, clone: pF1KE0644, Homo sapiens QRFPR gene for pyroglutamylated RFamide peptide receptor, without stop codon, in Flexi system.
AK309337 - Homo sapiens cDNA, FLJ99378.
JE973592 - Sequence 10 from Patent WO2015055857.
DL137677 - Novel nucleic acids.
JA611241 - Sequence 5 from Patent EP2374884.
KY994054 - Homo sapiens QXBT12 miRNA, complete sequence.
HI965323 - Sequence 608 from Patent WO2010139812.
HZ074782 - JP 2013535982-A/873: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
JA401361 - Sequence 608 from Patent WO2011080318.
JA402339 - Sequence 608 from Patent WO2011080315.
JA403346 - Sequence 608 from Patent WO2011080316.
JA405977 - Sequence 608 from Patent EP2336353.
JA427313 - Sequence 646 from Patent WO2011072177.
JA429503 - Sequence 608 from Patent WO2011095623.
JB620967 - Sequence 947 from Patent WO2013063544.
JC037755 - Sequence 283 from Patent EP2643479.
LQ278538 - Sequence 77 from Patent WO2016066288.
MS834462 - Sequence 608 from Patent EP3112479.
MA405545 - WO 2018155427-A/319: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96P65 (Reactome details) participates in the following event(s):

R-HSA-389424 The orphan QRFP receptor can bind neuropeptide QRFP
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000394427.1, ENST00000394427.2, GPR103, NM_198179, Q96P65, QRFPR_HUMAN, uc318wqf.1, uc318wqf.2
UCSC ID: ENST00000394427.3_7
RefSeq Accession: NM_198179.3
Protein: Q96P65 (aka QRFPR_HUMAN or QRFR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.