Human Gene QRSL1 (ENST00000369046.8_4) from GENCODE V47lift37
  Description: glutaminyl-tRNA amidotransferase subunit QRSL1 (from RefSeq NM_018292.5)
Gencode Transcript: ENST00000369046.8_4
Gencode Gene: ENSG00000130348.11_6
Transcript (Including UTRs)
   Position: hg19 chr6:107,077,453-107,116,292 Size: 38,840 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr6:107,077,557-107,113,877 Size: 36,321 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:107,077,453-107,116,292)mRNA (may differ from genome)Protein (528 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GATA_HUMAN
DESCRIPTION: RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Short=Glu-AdT subunit A; EC=6.3.5.-; AltName: Full=Glutaminyl-tRNA synthase-like protein 1;
FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).
CATALYTIC ACTIVITY: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
SUBUNIT: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (PET112) and C (GATC) subunits.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the amidase family. GatA subfamily.
SEQUENCE CAUTION: Sequence=CAH72094.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: QRSL1
Diseases sorted by gene-association score: lymphogranuloma venereum (16), intestinal volvulus (6), mitochondrial disorders (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.98 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 156.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.40104-0.263 Picture PostScript Text
3' UTR -649.302415-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000120 - Amidase
IPR023631 - Amidase_dom
IPR004412 - GatA

Pfam Domains:
PF01425 - Amidase

SCOP Domains:
47807 - 5' to 3' exonuclease, C-terminal subdomain
75304 - Amidase signature (AS) enzymes

ModBase Predicted Comparative 3D Structure on Q9H0R6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004040 amidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

Biological Process:
GO:0006412 translation
GO:0031647 regulation of protein stability
GO:0032543 mitochondrial translation
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation

Cellular Component:
GO:0005739 mitochondrion
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex


-  Descriptions from all associated GenBank mRNAs
  AK225262 - Homo sapiens mRNA for glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 variant, clone: DMC05143.
AL136679 - Homo sapiens mRNA; cDNA DKFZp564C1278 (from clone DKFZp564C1278).
AK314694 - Homo sapiens cDNA, FLJ95548, highly similar to Homo sapiens glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 (QRSL1), mRNA.
AK225443 - Homo sapiens mRNA for glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 variant, clone: HRT02047.
BC014389 - Homo sapiens glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1, mRNA (cDNA clone MGC:907 IMAGE:3504569), complete cds.
AK001851 - Homo sapiens cDNA FLJ10989 fis, clone PLACE1001989, weakly similar to PUTATIVE AMIDASE (EC 3.5.1.4).
BC006084 - Homo sapiens glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1, mRNA (cDNA clone MGC:12589 IMAGE:3605968), complete cds.
AK022251 - Homo sapiens cDNA FLJ12189 fis, clone MAMMA1000841, moderately similar to PUTATIVE AMIDASE (EC 3.5.1.4).
AK023509 - Homo sapiens cDNA FLJ13447 fis, clone PLACE1002991, weakly similar to PUTATIVE AMIDASE (EC 3.5.1.4).
JF432225 - Synthetic construct Homo sapiens clone IMAGE:100073390 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 (QRSL1) gene, encodes complete protein.
KJ894176 - Synthetic construct Homo sapiens clone ccsbBroadEn_03570 QRSL1 gene, encodes complete protein.
CU675233 - Synthetic construct Homo sapiens gateway clone IMAGE:100019784 5' read QRSL1 mRNA.
JD490819 - Sequence 471843 from Patent EP1572962.
JD253365 - Sequence 234389 from Patent EP1572962.
JD025948 - Sequence 6972 from Patent EP1572962.
JD029074 - Sequence 10098 from Patent EP1572962.
AK055349 - Homo sapiens cDNA FLJ30787 fis, clone FEBRA2000928.
JD027101 - Sequence 8125 from Patent EP1572962.
JD030895 - Sequence 11919 from Patent EP1572962.
JD302895 - Sequence 283919 from Patent EP1572962.
JD305180 - Sequence 286204 from Patent EP1572962.
JD481241 - Sequence 462265 from Patent EP1572962.
JD208950 - Sequence 189974 from Patent EP1572962.
JD448560 - Sequence 429584 from Patent EP1572962.
JD352234 - Sequence 333258 from Patent EP1572962.
JD508230 - Sequence 489254 from Patent EP1572962.
JD084416 - Sequence 65440 from Patent EP1572962.
JD092550 - Sequence 73574 from Patent EP1572962.
JD430385 - Sequence 411409 from Patent EP1572962.
JD557489 - Sequence 538513 from Patent EP1572962.
JD557488 - Sequence 538512 from Patent EP1572962.
JD529550 - Sequence 510574 from Patent EP1572962.
JD529549 - Sequence 510573 from Patent EP1572962.
JD169888 - Sequence 150912 from Patent EP1572962.
JD169890 - Sequence 150914 from Patent EP1572962.
JD169889 - Sequence 150913 from Patent EP1572962.
JD306548 - Sequence 287572 from Patent EP1572962.
JD306549 - Sequence 287573 from Patent EP1572962.
JD258661 - Sequence 239685 from Patent EP1572962.
JD501042 - Sequence 482066 from Patent EP1572962.
JD049891 - Sequence 30915 from Patent EP1572962.
JD326294 - Sequence 307318 from Patent EP1572962.
JD147724 - Sequence 128748 from Patent EP1572962.
JD336637 - Sequence 317661 from Patent EP1572962.
JD373118 - Sequence 354142 from Patent EP1572962.
JD554959 - Sequence 535983 from Patent EP1572962.
JD119473 - Sequence 100497 from Patent EP1572962.
JD102421 - Sequence 83445 from Patent EP1572962.
JD195233 - Sequence 176257 from Patent EP1572962.
JD350000 - Sequence 331024 from Patent EP1572962.
JD298029 - Sequence 279053 from Patent EP1572962.
JD148175 - Sequence 129199 from Patent EP1572962.
JD232796 - Sequence 213820 from Patent EP1572962.
JD492936 - Sequence 473960 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
GLUTAMINDEG-PWY - L-glutamine degradation
PWY-5921 - glutaminyl-tRNAgln biosynthesis via transamidation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369046.1, ENST00000369046.2, ENST00000369046.3, ENST00000369046.4, ENST00000369046.5, ENST00000369046.6, ENST00000369046.7, GATA_HUMAN, NM_018292, Q5VWJ4, Q9H0R6, Q9HA60, Q9NV19, QRSL1 , uc318hhd.1, uc318hhd.2
UCSC ID: ENST00000369046.8_4
RefSeq Accession: NM_018292.5
Protein: Q9H0R6 (aka GATA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.