Human Gene R3HDM2 (ENST00000402412.6_9) from GENCODE V47lift37
  Description: R3H domain containing 2, transcript variant 19 (from RefSeq NM_001394031.1)
Gencode Transcript: ENST00000402412.6_9
Gencode Gene: ENSG00000179912.21_15
Transcript (Including UTRs)
   Position: hg19 chr12:57,647,547-57,824,826 Size: 177,280 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr12:57,648,556-57,704,211 Size: 55,656 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,647,547-57,824,826)mRNA (may differ from genome)Protein (990 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: B5MCU0_HUMAN
DESCRIPTION: SubName: Full=R3H domain-containing protein 2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.28 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 688.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -160.57429-0.374 Picture PostScript Text
3' UTR -296.301009-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001374 - R3H_ss-bd
IPR024771 - SUZ

Pfam Domains:
PF01424 - R3H domain
PF12752 - SUZ domain

SCOP Domains:
82708 - R3H domain

ModBase Predicted Comparative 3D Structure on B5MCU0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding


-  Descriptions from all associated GenBank mRNAs
  AK293394 - Homo sapiens cDNA FLJ60419 complete cds, highly similar to R3H domain-containing protein 2.
BC041857 - Homo sapiens R3H domain containing 2, mRNA (cDNA clone MGC:43641 IMAGE:5270511), complete cds.
AB023219 - Homo sapiens mRNA for KIAA1002 protein, partial cds.
AX775761 - Sequence 31 from Patent WO03048202.
AX775763 - Sequence 33 from Patent WO03048202.
BC143605 - Homo sapiens R3H domain containing 2, mRNA (cDNA clone MGC:177135 IMAGE:9052118), complete cds.
BC104995 - Homo sapiens R3H domain containing 2, mRNA (cDNA clone MGC:132655 IMAGE:8143998), complete cds.
BC112226 - Homo sapiens R3H domain containing 2, mRNA (cDNA clone MGC:138431 IMAGE:8327694), complete cds.
KJ906074 - Synthetic construct Homo sapiens clone ccsbBroadEn_15744 R3HDM2 gene, encodes complete protein.
AB384552 - Synthetic construct DNA, clone: pF1KA1002, Homo sapiens R3HDM2 gene for R3H domain-containing protein 2, complete cds, without stop codon, in Flexi system.
X85326 - H.sapiens mRNA for non polymorphic CAG repeat (CAG6).
BC107434 - Homo sapiens cDNA clone IMAGE:6499407, partial cds.
BC008143 - Homo sapiens R3H domain containing 2, mRNA (cDNA clone IMAGE:3453090).
AF113695 - Homo sapiens clone FLB5224 PRO1365 mRNA, complete cds.
JD285121 - Sequence 266145 from Patent EP1572962.
JD128516 - Sequence 109540 from Patent EP1572962.
JD289404 - Sequence 270428 from Patent EP1572962.
JD259196 - Sequence 240220 from Patent EP1572962.
JD107663 - Sequence 88687 from Patent EP1572962.
JD560823 - Sequence 541847 from Patent EP1572962.
JD516481 - Sequence 497505 from Patent EP1572962.
JD365162 - Sequence 346186 from Patent EP1572962.
JD452469 - Sequence 433493 from Patent EP1572962.
JD397221 - Sequence 378245 from Patent EP1572962.
JD069893 - Sequence 50917 from Patent EP1572962.
DQ576498 - Homo sapiens piRNA piR-44610, complete sequence.
JD321804 - Sequence 302828 from Patent EP1572962.
JD155484 - Sequence 136508 from Patent EP1572962.
JD196788 - Sequence 177812 from Patent EP1572962.
JD211914 - Sequence 192938 from Patent EP1572962.
JD542409 - Sequence 523433 from Patent EP1572962.
JD560875 - Sequence 541899 from Patent EP1572962.
JD262015 - Sequence 243039 from Patent EP1572962.
JD087008 - Sequence 68032 from Patent EP1572962.
JD448868 - Sequence 429892 from Patent EP1572962.
JD139411 - Sequence 120435 from Patent EP1572962.
JD513703 - Sequence 494727 from Patent EP1572962.
JD295731 - Sequence 276755 from Patent EP1572962.
JD262357 - Sequence 243381 from Patent EP1572962.
JD154232 - Sequence 135256 from Patent EP1572962.
JD198776 - Sequence 179800 from Patent EP1572962.
JD492113 - Sequence 473137 from Patent EP1572962.
JD492114 - Sequence 473138 from Patent EP1572962.
JD492115 - Sequence 473139 from Patent EP1572962.
JD558441 - Sequence 539465 from Patent EP1572962.
JD448958 - Sequence 429982 from Patent EP1572962.
JD316756 - Sequence 297780 from Patent EP1572962.
JD541031 - Sequence 522055 from Patent EP1572962.
JD117600 - Sequence 98624 from Patent EP1572962.
DQ572726 - Homo sapiens piRNA piR-40838, complete sequence.
MP015202 - Sequence 405 from Patent WO2019016252.

-  Other Names for This Gene
  Alternate Gene Symbols: B5MCU0, B5MCU0_HUMAN, ENST00000402412.1, ENST00000402412.2, ENST00000402412.3, ENST00000402412.4, ENST00000402412.5, NM_001394031, R3HDM2 , uc319buo.1, uc319buo.2
UCSC ID: ENST00000402412.6_9
RefSeq Accession: NM_001394031.1
Protein: B5MCU0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.