ID:RB11A_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-11A; Short=Rab-11; AltName: Full=YL8; Flags: Precursor; FUNCTION: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). SUBUNIT: Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP- dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. INTERACTION: Q7L804:RAB11FIP2; NbExp=2; IntAct=EBI-745098, EBI-1049676; Q5T4F4:ZFYVE27; NbExp=4; IntAct=EBI-745098, EBI-3892947; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62491
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003091 renal water homeostasis GO:0007049 cell cycle GO:0007080 mitotic metaphase plate congression GO:0010634 positive regulation of epithelial cell migration GO:0010796 regulation of multivesicular body size GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0030953 astral microtubule organization GO:0031175 neuron projection development GO:0032402 melanosome transport GO:0032465 regulation of cytokinesis GO:0036258 multivesicular body assembly GO:0043687 post-translational protein modification GO:0045773 positive regulation of axon extension GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0048227 plasma membrane to endosome transport GO:0051223 regulation of protein transport GO:0051650 establishment of vesicle localization GO:0060627 regulation of vesicle-mediated transport GO:0072594 establishment of protein localization to organelle GO:0072659 protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090307 mitotic spindle assembly GO:0097711 ciliary basal body docking GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane GO:1903078 positive regulation of protein localization to plasma membrane GO:1990182 exosomal secretion
AK297549 - Homo sapiens cDNA FLJ61136 complete cds, highly similar to Ras-related protein Rab-11A. AK298961 - Homo sapiens cDNA FLJ57160 complete cds, highly similar to Ras-related protein Rab-11A. AK311770 - Homo sapiens cDNA, FLJ92031, Homo sapiens RAB11A, member RAS oncogene family (RAB11A), mRNA. BC013348 - Homo sapiens RAB11A, member RAS oncogene family, mRNA (cDNA clone MGC:1490 IMAGE:3510339), complete cds. AF000231 - Homo sapiens rab11a GTPase mRNA, complete cds. JD427006 - Sequence 408030 from Patent EP1572962. X56740 - H.sapiens mRNA for Rab11 gene. AK300008 - Homo sapiens cDNA FLJ51542 complete cds, highly similar to Ras-related protein Rab-11B. DL492121 - Novel nucleic acids. CR407669 - Homo sapiens full open reading frame cDNA clone RZPDo834B053D for gene RAB11A, RAB11A, member RAS oncogene family complete cds, without stopcodon. DQ896303 - Synthetic construct Homo sapiens clone IMAGE:100010763; FLH193100.01L; RZPDo839C1268D RAB11A, member RAS oncogene family (RAB11A) gene, encodes complete protein. BT020151 - Homo sapiens RAB11A, member RAS oncogene family mRNA, complete cds. BT020154 - Homo sapiens RAB11A, member RAS oncogene family mRNA, complete cds. DQ893054 - Synthetic construct clone IMAGE:100005684; FLH193104.01X; RZPDo839C1278D RAB11A, member RAS oncogene family (RAB11A) gene, encodes complete protein. KJ892615 - Synthetic construct Homo sapiens clone ccsbBroadEn_02009 RAB11A gene, encodes complete protein. AF498946 - Homo sapiens small GTP binding protein RAB11A (RAB11A) mRNA, complete cds. CR536493 - Homo sapiens full open reading frame cDNA clone RZPDo834F1017D for gene RAB11A, RAB11A, member RAS oncogene family; complete cds, incl. stopcodon. X53143 - Human YL8 mRNA for ras-like protein. DL490657 - Novel nucleic acids. JD019002 - Sequence 26 from Patent EP1572962. JD032833 - Sequence 13857 from Patent EP1572962. JD045220 - Sequence 26244 from Patent EP1572962. JD435790 - Sequence 416814 from Patent EP1572962. JD494523 - Sequence 475547 from Patent EP1572962. JD094311 - Sequence 75335 from Patent EP1572962. JD313373 - Sequence 294397 from Patent EP1572962. JD147871 - Sequence 128895 from Patent EP1572962. JD545545 - Sequence 526569 from Patent EP1572962. JD152524 - Sequence 133548 from Patent EP1572962. JD509214 - Sequence 490238 from Patent EP1572962. JD346022 - Sequence 327046 from Patent EP1572962. JD088798 - Sequence 69822 from Patent EP1572962. JD256552 - Sequence 237576 from Patent EP1572962. JD476736 - Sequence 457760 from Patent EP1572962. JD414849 - Sequence 395873 from Patent EP1572962. JD379695 - Sequence 360719 from Patent EP1572962. JD311826 - Sequence 292850 from Patent EP1572962. JD081627 - Sequence 62651 from Patent EP1572962. JD081628 - Sequence 62652 from Patent EP1572962. BC047114 - Homo sapiens cDNA clone IMAGE:5313062.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_rabPathway - Rab GTPases Mark Targets In The Endocytotic Machinery
Reactome (by CSHL, EBI, and GO)
Protein P62491 (Reactome details) participates in the following event(s):
R-HSA-8854759 TBC1D14 binds RAB11 and ULK1 R-HSA-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex R-HSA-5623513 ASAP1 stimulates GTPase activity of ARF4 R-HSA-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex R-HSA-5638014 RAB11A:GTP-containing Golgi vesicles recruit RAB3IP R-HSA-8870466 RGGT:CHM binds RABs R-HSA-5623521 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-8870469 RGGT geranylgeranylates RAB proteins R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-8854214 TBC/RABGAPs R-HSA-5620916 VxPx cargo-targeting to cilium R-HSA-9007101 Rab regulation of trafficking R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-8873719 RAB geranylgeranylation R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-199991 Membrane Trafficking R-HSA-5617833 Cilium Assembly R-HSA-597592 Post-translational protein modification R-HSA-445717 Aquaporin-mediated transport R-HSA-5653656 Vesicle-mediated transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-392499 Metabolism of proteins R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
