Human Gene RAB11FIP2 (ENST00000355624.8_7) from GENCODE V47lift37
  Description: RAB11 family interacting protein 2, transcript variant 1 (from RefSeq NM_014904.3)
Gencode Transcript: ENST00000355624.8_7
Gencode Gene: ENSG00000107560.12_10
Transcript (Including UTRs)
   Position: hg19 chr10:119,764,427-119,806,452 Size: 42,026 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr10:119,768,509-119,805,674 Size: 37,166 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:119,764,427-119,806,452)mRNA (may differ from genome)Protein (512 aa)
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-  Comments and Description Text from UniProtKB
  ID: RFIP2_HUMAN
DESCRIPTION: RecName: Full=Rab11 family-interacting protein 2; Short=Rab11-FIP2; AltName: Full=NRip11;
FUNCTION: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
SUBUNIT: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding. Interacts with NPC1L1.
INTERACTION: P62491:RAB11A; NbExp=2; IntAct=EBI-1049676, EBI-745098;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
PTM: Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
SIMILARITY: Contains 1 C2 domain.
SIMILARITY: Contains 1 FIP-RBD domain.
SEQUENCE CAUTION: Sequence=BAA76785.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.62 RPKM in Uterus
Total median expression: 292.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -429.90778-0.553 Picture PostScript Text
3' UTR -923.004082-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR019018 - Rab-bd_FIP-RBD

Pfam Domains:
PF00168 - C2 domain
PF09457 - FIP domain

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
144270 - Eferin C-derminal domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2GZD - X-ray MuPIT 2GZH - X-ray MuPIT 2K6S - NMR MuPIT 3TSO - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q7L804
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0003091 renal water homeostasis
GO:0015031 protein transport
GO:0030010 establishment of cell polarity
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0045055 regulated exocytosis
GO:1903078 positive regulation of protein localization to plasma membrane

Cellular Component:
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055038 recycling endosome membrane


-  Descriptions from all associated GenBank mRNAs
  AB023158 - Homo sapiens KIAA0941 mRNA for KIAA0941 protein.
AY037299 - Homo sapiens nRip11 mRNA, complete cds.
BC075073 - Homo sapiens RAB11 family interacting protein 2 (class I), mRNA (cDNA clone MGC:104137 IMAGE:30915593), complete cds.
BC075074 - Homo sapiens RAB11 family interacting protein 2 (class I), mRNA (cDNA clone MGC:103973 IMAGE:30915380), complete cds.
DQ013303 - Homo sapiens RAB11-FIP2 long isoform mRNA, complete cds, alternatively spliced.
AB384053 - Synthetic construct DNA, clone: pF1KSDA0941, Homo sapiens RAB11FIP2 gene for RAB11 family-interacting protein 2, complete cds, without stop codon, in Flexi system.
KJ898414 - Synthetic construct Homo sapiens clone ccsbBroadEn_07808 RAB11FIP2 gene, encodes complete protein.
BX647717 - Homo sapiens mRNA; cDNA DKFZp686L10277 (from clone DKFZp686L10277).
JD410882 - Sequence 391906 from Patent EP1572962.
JD273915 - Sequence 254939 from Patent EP1572962.
JD317156 - Sequence 298180 from Patent EP1572962.
JD410902 - Sequence 391926 from Patent EP1572962.
JD416534 - Sequence 397558 from Patent EP1572962.
JD300763 - Sequence 281787 from Patent EP1572962.
JD090868 - Sequence 71892 from Patent EP1572962.
JD237510 - Sequence 218534 from Patent EP1572962.
JD352352 - Sequence 333376 from Patent EP1572962.
JD273757 - Sequence 254781 from Patent EP1572962.
JD281224 - Sequence 262248 from Patent EP1572962.
JD531137 - Sequence 512161 from Patent EP1572962.
JD345329 - Sequence 326353 from Patent EP1572962.
JD494921 - Sequence 475945 from Patent EP1572962.
JD552740 - Sequence 533764 from Patent EP1572962.
JD236412 - Sequence 217436 from Patent EP1572962.
JD538571 - Sequence 519595 from Patent EP1572962.
JD511064 - Sequence 492088 from Patent EP1572962.
JD180923 - Sequence 161947 from Patent EP1572962.
JD504085 - Sequence 485109 from Patent EP1572962.
JD262720 - Sequence 243744 from Patent EP1572962.
JD437164 - Sequence 418188 from Patent EP1572962.
JD046599 - Sequence 27623 from Patent EP1572962.
JD226014 - Sequence 207038 from Patent EP1572962.
JD267558 - Sequence 248582 from Patent EP1572962.
JD561975 - Sequence 542999 from Patent EP1572962.
JD345300 - Sequence 326324 from Patent EP1572962.
JD073314 - Sequence 54338 from Patent EP1572962.
JD328380 - Sequence 309404 from Patent EP1572962.
JD317872 - Sequence 298896 from Patent EP1572962.
JD396956 - Sequence 377980 from Patent EP1572962.
JD520843 - Sequence 501867 from Patent EP1572962.
JD131545 - Sequence 112569 from Patent EP1572962.
JD074957 - Sequence 55981 from Patent EP1572962.
JD179163 - Sequence 160187 from Patent EP1572962.
JD474822 - Sequence 455846 from Patent EP1572962.
JD471708 - Sequence 452732 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7L804 (Reactome details) participates in the following event(s):

R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-445717 Aquaporin-mediated transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A6NEI4, ENST00000355624.1, ENST00000355624.2, ENST00000355624.3, ENST00000355624.4, ENST00000355624.5, ENST00000355624.6, ENST00000355624.7, KIAA0941, NM_014904, Q3I768, Q7L804, Q9Y2F0, RFIP2_HUMAN, uc317zea.1, uc317zea.2
UCSC ID: ENST00000355624.8_7
RefSeq Accession: NM_014904.3
Protein: Q7L804 (aka RFIP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.