Human Gene RAB15 (ENST00000533601.7_8) from GENCODE V47lift37
  Description: RAB15, member RAS oncogene family, transcript variant 2 (from RefSeq NM_001308154.2)
Gencode Transcript: ENST00000533601.7_8
Gencode Gene: ENSG00000139998.16_11
Transcript (Including UTRs)
   Position: hg19 chr14:65,412,534-65,439,054 Size: 26,521 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr14:65,415,072-65,438,794 Size: 23,723 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:65,412,534-65,439,054)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAB15_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-15;
FUNCTION: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal (By similarity).
SUBUNIT: The GTP bound form of RAB15 interacts with REP15.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 68.21 RPKM in Brain - Cerebellum
Total median expression: 529.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -151.30260-0.582 Picture PostScript Text
3' UTR -937.102538-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on P59190
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0006904 vesicle docking involved in exocytosis
GO:0009306 protein secretion
GO:0015031 protein transport
GO:1903307 positive regulation of regulated secretory pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC014511 - Homo sapiens RAB15, member RAS onocogene family, mRNA (cDNA clone IMAGE:4866926), with apparent retained intron.
BC040679 - Homo sapiens RAB15, member RAS onocogene family, mRNA (cDNA clone MGC:42319 IMAGE:4817835), complete cds.
BX248046 - human full-length cDNA clone CS0DI028YM11 of Placenta of Homo sapiens (human).
JD173645 - Sequence 154669 from Patent EP1572962.
JD271743 - Sequence 252767 from Patent EP1572962.
JD513280 - Sequence 494304 from Patent EP1572962.
JD433427 - Sequence 414451 from Patent EP1572962.
JD133719 - Sequence 114743 from Patent EP1572962.
JD133718 - Sequence 114742 from Patent EP1572962.
JD384934 - Sequence 365958 from Patent EP1572962.
JD539033 - Sequence 520057 from Patent EP1572962.
JD067077 - Sequence 48101 from Patent EP1572962.
JD204221 - Sequence 185245 from Patent EP1572962.
JD360493 - Sequence 341517 from Patent EP1572962.
JD357722 - Sequence 338746 from Patent EP1572962.
JD306239 - Sequence 287263 from Patent EP1572962.
JD423326 - Sequence 404350 from Patent EP1572962.
JD189056 - Sequence 170080 from Patent EP1572962.
JD217371 - Sequence 198395 from Patent EP1572962.
JD114895 - Sequence 95919 from Patent EP1572962.
JD038603 - Sequence 19627 from Patent EP1572962.
JD360945 - Sequence 341969 from Patent EP1572962.
JD288524 - Sequence 269548 from Patent EP1572962.
JD296467 - Sequence 277491 from Patent EP1572962.
BX640825 - Homo sapiens mRNA; cDNA DKFZp686J06205 (from clone DKFZp686J06205).
JD284597 - Sequence 265621 from Patent EP1572962.
JD208838 - Sequence 189862 from Patent EP1572962.
JD316336 - Sequence 297360 from Patent EP1572962.
JD135229 - Sequence 116253 from Patent EP1572962.
JD309179 - Sequence 290203 from Patent EP1572962.
JD315421 - Sequence 296445 from Patent EP1572962.
JD535319 - Sequence 516343 from Patent EP1572962.
JD353785 - Sequence 334809 from Patent EP1572962.
JD120068 - Sequence 101092 from Patent EP1572962.
JD099492 - Sequence 80516 from Patent EP1572962.
JD036674 - Sequence 17698 from Patent EP1572962.
JD330631 - Sequence 311655 from Patent EP1572962.
JD119677 - Sequence 100701 from Patent EP1572962.
JD121687 - Sequence 102711 from Patent EP1572962.
JD468380 - Sequence 449404 from Patent EP1572962.
JD510259 - Sequence 491283 from Patent EP1572962.
JD338196 - Sequence 319220 from Patent EP1572962.
JD229573 - Sequence 210597 from Patent EP1572962.
JD283748 - Sequence 264772 from Patent EP1572962.
JD094788 - Sequence 75812 from Patent EP1572962.
JD538616 - Sequence 519640 from Patent EP1572962.
JD488483 - Sequence 469507 from Patent EP1572962.
JD181194 - Sequence 162218 from Patent EP1572962.
JD158276 - Sequence 139300 from Patent EP1572962.
JD383573 - Sequence 364597 from Patent EP1572962.
JD104608 - Sequence 85632 from Patent EP1572962.
JD266318 - Sequence 247342 from Patent EP1572962.
JD194235 - Sequence 175259 from Patent EP1572962.
JD415938 - Sequence 396962 from Patent EP1572962.
JD345494 - Sequence 326518 from Patent EP1572962.
JD077136 - Sequence 58160 from Patent EP1572962.
AB678453 - Homo sapiens RAB15 mRNA for Ras-related protein Rab-15 isoform CN, complete cds.
JD071750 - Sequence 52774 from Patent EP1572962.
JD368642 - Sequence 349666 from Patent EP1572962.
JD060483 - Sequence 41507 from Patent EP1572962.
JD234583 - Sequence 215607 from Patent EP1572962.
AB672632 - Homo sapiens RAB15 mRNA for Ras-related protein Rab-15 isoform AN3, complete cds.
AB672631 - Homo sapiens RAB15 mRNA for Ras-related protein Rab-15 isoform AN2, complete cds.
AB678452 - Homo sapiens RAB15 mRNA for Ras-related protein Rab-15 isoform AN1, complete cds.
HQ447970 - Synthetic construct Homo sapiens clone IMAGE:100071335; CCSB010403_02 RAB15, member RAS onocogene family (RAB15) gene, encodes complete protein.
KJ896158 - Synthetic construct Homo sapiens clone ccsbBroadEn_05552 RAB15 gene, encodes complete protein.
CU691918 - Synthetic construct Homo sapiens gateway clone IMAGE:100020838 5' read RAB15 mRNA.
JD211109 - Sequence 192133 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P59190 (Reactome details) participates in the following event(s):

R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-8873719 RAB geranylgeranylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000533601.1, ENST00000533601.2, ENST00000533601.3, ENST00000533601.4, ENST00000533601.5, ENST00000533601.6, G5EMR7, NM_001308154, P59190, Q86TX7, Q8IW89, RAB15_HUMAN, uc324lso.1, uc324lso.2
UCSC ID: ENST00000533601.7_8
RefSeq Accession: NM_001308154.2
Protein: P59190 (aka RAB15_HUMAN or RB15_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.