Human Gene RAB24 (ENST00000303251.11_7) from GENCODE V47lift37
  Description: RAB24, member RAS oncogene family, transcript variant 2 (from RefSeq NM_130781.4)
Gencode Transcript: ENST00000303251.11_7
Gencode Gene: ENSG00000169228.14_12
Transcript (Including UTRs)
   Position: hg19 chr5:176,728,199-176,730,720 Size: 2,522 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr5:176,728,744-176,730,289 Size: 1,546 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:176,728,199-176,730,720)mRNA (may differ from genome)Protein (203 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAB24_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-24;
FUNCTION: May be involved in autophagy-related processes (By similarity).
SUBUNIT: Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about 20-25% is recovered in the particulate fraction.
INDUCTION: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).
PTM: Isoprenylation is inefficient compared to other Rab family members.
MISCELLANEOUS: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.90 RPKM in Whole Blood
Total median expression: 1414.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -226.70431-0.526 Picture PostScript Text
3' UTR -201.20545-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q969Q5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0006914 autophagy
GO:0015031 protein transport
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030667 secretory granule membrane


-  Descriptions from all associated GenBank mRNAs
  LF213791 - JP 2014500723-A/21294: Polycomb-Associated Non-Coding RNAs.
LF209799 - JP 2014500723-A/17302: Polycomb-Associated Non-Coding RNAs.
AF087904 - Homo sapiens rab24 mRNA, complete cds.
BC021263 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:29471 IMAGE:4329216), complete cds.
AL833898 - Homo sapiens mRNA; cDNA DKFZp761H152 (from clone DKFZp761H152).
BC010006 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:15055 IMAGE:4300377), complete cds.
BC015534 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:9474 IMAGE:3916832), complete cds.
AK021761 - Homo sapiens cDNA FLJ11699 fis, clone HEMBA1005047, highly similar to RAS-RELATED PROTEIN RAB-24.
AF258583 - Homo sapiens PP4748 mRNA, complete cds.
JD248570 - Sequence 229594 from Patent EP1572962.
JD112666 - Sequence 93690 from Patent EP1572962.
JD396383 - Sequence 377407 from Patent EP1572962.
JD266699 - Sequence 247723 from Patent EP1572962.
JD111017 - Sequence 92041 from Patent EP1572962.
AK308155 - Homo sapiens cDNA, FLJ98103.
JD317787 - Sequence 298811 from Patent EP1572962.
BT007268 - Homo sapiens RAB24, member RAS oncogene family mRNA, complete cds.
DQ891036 - Synthetic construct clone IMAGE:100003666; FLH168721.01X; RZPDo839C0694D RAB24, member RAS oncogene family (RAB24) gene, encodes complete protein.
DQ894215 - Synthetic construct Homo sapiens clone IMAGE:100008675; FLH168717.01L; RZPDo839C0693D RAB24, member RAS oncogene family (RAB24) gene, encodes complete protein.
EU831626 - Synthetic construct Homo sapiens clone HAIB:100066655; DKFZo007D1119 RAB24, member RAS oncogene family protein (RAB24) gene, encodes complete protein.
EU831711 - Synthetic construct Homo sapiens clone HAIB:100066740; DKFZo003D1120 RAB24, member RAS oncogene family protein (RAB24) gene, encodes complete protein.
JD448781 - Sequence 429805 from Patent EP1572962.
JD316968 - Sequence 297992 from Patent EP1572962.
JD356823 - Sequence 337847 from Patent EP1572962.
JD557140 - Sequence 538164 from Patent EP1572962.
JD563083 - Sequence 544107 from Patent EP1572962.
JD394536 - Sequence 375560 from Patent EP1572962.
JD345301 - Sequence 326325 from Patent EP1572962.
JD450271 - Sequence 431295 from Patent EP1572962.
JD229091 - Sequence 210115 from Patent EP1572962.
LF331750 - JP 2014500723-A/139253: Polycomb-Associated Non-Coding RNAs.
JD058131 - Sequence 39155 from Patent EP1572962.
JD219707 - Sequence 200731 from Patent EP1572962.
JD404593 - Sequence 385617 from Patent EP1572962.
JD408863 - Sequence 389887 from Patent EP1572962.
JD072752 - Sequence 53776 from Patent EP1572962.
JD141656 - Sequence 122680 from Patent EP1572962.
MA567327 - JP 2018138019-A/139253: Polycomb-Associated Non-Coding RNAs.
MA449368 - JP 2018138019-A/21294: Polycomb-Associated Non-Coding RNAs.
MA445376 - JP 2018138019-A/17302: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q969Q5 (Reactome details) participates in the following event(s):

R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-8873719 RAB geranylgeranylation
R-HSA-168256 Immune System
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R7N9, ENST00000303251.1, ENST00000303251.10, ENST00000303251.2, ENST00000303251.3, ENST00000303251.4, ENST00000303251.5, ENST00000303251.6, ENST00000303251.7, ENST00000303251.8, ENST00000303251.9, NM_130781, Q7Z4Z7, Q969Q5, RAB24_HUMAN, uc317nfa.1, uc317nfa.2
UCSC ID: ENST00000303251.11_7
RefSeq Accession: NM_001031677.4
Protein: Q969Q5 (aka RAB24_HUMAN or RB24_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.