Human Gene RABIF (ENST00000367262.4_7) from GENCODE V47lift37
  Description: RAB interacting factor (from RefSeq NM_002871.5)
Gencode Transcript: ENST00000367262.4_7
Gencode Gene: ENSG00000183155.5_9
Transcript (Including UTRs)
   Position: hg19 chr1:202,847,410-202,858,277 Size: 10,868 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr1:202,850,106-202,858,226 Size: 8,121 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:202,847,410-202,858,277)mRNA (may differ from genome)Protein (123 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MSS4_HUMAN
DESCRIPTION: RecName: Full=Guanine nucleotide exchange factor MSS4; AltName: Full=Rab-interacting factor;
FUNCTION: Guanine-nucleotide-releasing protein that acts on members of the SCE4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the DSS4/MSS4 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.27 RPKM in Testis
Total median expression: 214.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.6051-0.424 Picture PostScript Text
3' UTR -758.602696-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007515 - Mss4
IPR011057 - Mss4-like
IPR011323 - Mss4/transl-control_tumor

Pfam Domains:
PF04421 - Mss4 protein

SCOP Domains:
51316 - Mss4-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1FWQ - NMR MuPIT 2FU5 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P47224
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Ensembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0061025 membrane fusion

Cellular Component:
GO:0005829 cytosol
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC037392 - Homo sapiens RAB interacting factor, mRNA (cDNA clone MGC:34651 IMAGE:5191960), complete cds.
U74324 - Human guanine nucleotide exchange factor mss4 mRNA, complete cds.
JD241440 - Sequence 222464 from Patent EP1572962.
JD050869 - Sequence 31893 from Patent EP1572962.
JD097464 - Sequence 78488 from Patent EP1572962.
JD512536 - Sequence 493560 from Patent EP1572962.
JD350992 - Sequence 332016 from Patent EP1572962.
JD182514 - Sequence 163538 from Patent EP1572962.
JD331778 - Sequence 312802 from Patent EP1572962.
JD308757 - Sequence 289781 from Patent EP1572962.
JD096319 - Sequence 77343 from Patent EP1572962.
JD334167 - Sequence 315191 from Patent EP1572962.
JD350991 - Sequence 332015 from Patent EP1572962.
JD497934 - Sequence 478958 from Patent EP1572962.
JD120442 - Sequence 101466 from Patent EP1572962.
JD327174 - Sequence 308198 from Patent EP1572962.
JD472209 - Sequence 453233 from Patent EP1572962.
JD145384 - Sequence 126408 from Patent EP1572962.
JD136284 - Sequence 117308 from Patent EP1572962.
JD194921 - Sequence 175945 from Patent EP1572962.
JD279274 - Sequence 260298 from Patent EP1572962.
JD136283 - Sequence 117307 from Patent EP1572962.
JD537425 - Sequence 518449 from Patent EP1572962.
JD194920 - Sequence 175944 from Patent EP1572962.
JD110571 - Sequence 91595 from Patent EP1572962.
JD314653 - Sequence 295677 from Patent EP1572962.
JD277877 - Sequence 258901 from Patent EP1572962.
JD127542 - Sequence 108566 from Patent EP1572962.
JD091817 - Sequence 72841 from Patent EP1572962.
JD285775 - Sequence 266799 from Patent EP1572962.
JD144967 - Sequence 125991 from Patent EP1572962.
JD096129 - Sequence 77153 from Patent EP1572962.
JD241666 - Sequence 222690 from Patent EP1572962.
JD181092 - Sequence 162116 from Patent EP1572962.
JD383630 - Sequence 364654 from Patent EP1572962.
JD433812 - Sequence 414836 from Patent EP1572962.
JD474710 - Sequence 455734 from Patent EP1572962.
JD436678 - Sequence 417702 from Patent EP1572962.
JD338112 - Sequence 319136 from Patent EP1572962.
JD508676 - Sequence 489700 from Patent EP1572962.
JD307964 - Sequence 288988 from Patent EP1572962.
JD344989 - Sequence 326013 from Patent EP1572962.
S78873 - mss4=Zn2+ binding protein/guanine nucleotide exchange factor [human, brain, mRNA Partial, 922 nt].
JD281087 - Sequence 262111 from Patent EP1572962.
JD305045 - Sequence 286069 from Patent EP1572962.
JD302136 - Sequence 283160 from Patent EP1572962.
JD127385 - Sequence 108409 from Patent EP1572962.
JD127384 - Sequence 108408 from Patent EP1572962.
JD383249 - Sequence 364273 from Patent EP1572962.
BC018488 - Homo sapiens RAB interacting factor, mRNA (cDNA clone MGC:21266 IMAGE:4475846), complete cds.
JD082645 - Sequence 63669 from Patent EP1572962.
JD500349 - Sequence 481373 from Patent EP1572962.
AK223538 - Homo sapiens mRNA for RAB-interacting factor variant, clone: FCC125B06.
AK311900 - Homo sapiens cDNA, FLJ92166, Homo sapiens RAB interacting factor (RABIF), mRNA.
BT007133 - Homo sapiens RAB interacting factor mRNA, complete cds.
KJ891971 - Synthetic construct Homo sapiens clone ccsbBroadEn_01365 RABIF gene, encodes complete protein.
AB464114 - Synthetic construct DNA, clone: pF1KB8163, Homo sapiens RABIF gene for RAB interacting factor, without stop codon, in Flexi system.
DQ573044 - Homo sapiens piRNA piR-41156, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4P4, ENST00000367262.1, ENST00000367262.2, ENST00000367262.3, MSS4, MSS4_HUMAN, NM_002871, P47224, Q92992, RASGRF3, uc318ftx.1, uc318ftx.2
UCSC ID: ENST00000367262.4_7
RefSeq Accession: NM_002871.5
Protein: P47224 (aka MSS4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.