ID:RAC3_HUMAN DESCRIPTION: RecName: Full=Ras-related C3 botulinum toxin substrate 3; AltName: Full=p21-Rac3; Flags: Precursor; FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. INTERACTION: P03372:ESR1; NbExp=5; IntAct=EBI-767084, EBI-78473; Q9UHY1:NRBP1; NbExp=3; IntAct=EBI-767084, EBI-749731; SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. TISSUE SPECIFICITY: Highest levels in brain, also detected in heart, placenta and pancreas. INDUCTION: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60763
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007264 small GTPase mediated signal transduction GO:0014041 regulation of neuron maturation GO:0021894 cerebral cortex GABAergic interneuron development GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0030036 actin cytoskeleton organization GO:0031175 neuron projection development GO:0033630 positive regulation of cell adhesion mediated by integrin GO:0035556 intracellular signal transduction GO:0048873 homeostasis of number of cells within a tissue GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0051056 regulation of small GTPase mediated signal transduction GO:0051932 synaptic transmission, GABAergic GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
