ID:RAD18_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RAD18; EC=6.3.2.-; AltName: Full=Postreplication repair protein RAD18; Short=hHR18; Short=hRAD18; AltName: Full=RING finger protein 73; FUNCTION: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with UBE2A and UBE2B. Interacts with HLTF and SHPRH. Interacts with SPRTN; leading to enhance chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the RAD18 family. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SAP domain. SIMILARITY: Contains 1 UBZ-type zinc finger. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rad18/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS91
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006301 postreplication repair GO:0006513 protein monoubiquitination GO:0006974 cellular response to DNA damage stimulus GO:0009411 response to UV GO:0016567 protein ubiquitination GO:0042769 DNA damage response, detection of DNA damage GO:0051865 protein autoubiquitination GO:0051984 positive regulation of chromosome segregation GO:0060548 negative regulation of cell death
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
