Human Gene RAD52 (ENST00000358495.8_11) from GENCODE V47lift37
  Description: RAD52 homolog, DNA repair protein, transcript variant 1 (from RefSeq NM_134424.4)
Gencode Transcript: ENST00000358495.8_11
Gencode Gene: ENSG00000002016.18_15
Transcript (Including UTRs)
   Position: hg19 chr12:1,020,902-1,058,860 Size: 37,959 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr12:1,022,557-1,042,224 Size: 19,668 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:1,020,902-1,058,860)mRNA (may differ from genome)Protein (418 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.72 RPKM in Brain - Cerebellum
Total median expression: 200.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.40111-0.211 Picture PostScript Text
3' UTR -473.741655-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004585 - DNA_recomb/repair_Rad52
IPR007232 - Rad52_Rad22

Pfam Domains:
PF04098 - Rad52/22 family double-strand break repair protein

SCOP Domains:
54768 - dsRNA-binding domain-like

ModBase Predicted Comparative 3D Structure on Q5DR82
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
GO:0034599 cellular response to oxidative stress
GO:0045002 double-strand break repair via single-strand annealing

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC042136 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5802809), with apparent retained intron.
AF125948 - Homo sapiens DNA repair protein RAD52 delta isoform (RAD52) mRNA, alternatively spliced, complete cds.
L33262 - Homo sapiens DNA repair and recombination homologue (RAD52) gene, complete cds.
AF125949 - Homo sapiens DNA repair protein RAD52 gamma isoform (RAD52) mRNA, alternatively spliced, complete cds.
AK290047 - Homo sapiens cDNA FLJ77029 complete cds, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant alpha, mRNA.
AK299283 - Homo sapiens cDNA FLJ57177 complete cds, highly similar to DNA repair protein RAD52 homolog.
BC114507 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:40024511).
BC104015 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:40024504), partial cds.
BC104016 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:40024507).
BC104017 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:40024509), partial cds.
BC114954 - Homo sapiens RAD52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:40024512), complete cds.
AK294709 - Homo sapiens cDNA FLJ56674 complete cds, highly similar to DNA repair protein RAD52 homolog.
AK292160 - Homo sapiens cDNA FLJ76573 complete cds, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant gamma, mRNA.
AK312026 - Homo sapiens cDNA, FLJ92302, Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcriptvariant delta, mRNA.
U12134 - Human DNA damage repair and recombination protein RAD52 mRNA, complete cds.
U27516 - Human recombination protein RAD52 mRNA, complete cds.
BC144458 - Homo sapiens cDNA clone IMAGE:9052984.
JD172470 - Sequence 153494 from Patent EP1572962.
JD539568 - Sequence 520592 from Patent EP1572962.
JD523641 - Sequence 504665 from Patent EP1572962.
JD042671 - Sequence 23695 from Patent EP1572962.
JD215068 - Sequence 196092 from Patent EP1572962.
JD083432 - Sequence 64456 from Patent EP1572962.
JD047033 - Sequence 28057 from Patent EP1572962.
JD427305 - Sequence 408329 from Patent EP1572962.
JD241332 - Sequence 222356 from Patent EP1572962.
JD356864 - Sequence 337888 from Patent EP1572962.
JD313398 - Sequence 294422 from Patent EP1572962.
JD121135 - Sequence 102159 from Patent EP1572962.
JD456516 - Sequence 437540 from Patent EP1572962.
JD262215 - Sequence 243239 from Patent EP1572962.
JD376234 - Sequence 357258 from Patent EP1572962.
JD515941 - Sequence 496965 from Patent EP1572962.
JD293653 - Sequence 274677 from Patent EP1572962.
JD467500 - Sequence 448524 from Patent EP1572962.
JD192571 - Sequence 173595 from Patent EP1572962.
JD550399 - Sequence 531423 from Patent EP1572962.
JD329801 - Sequence 310825 from Patent EP1572962.
JD441728 - Sequence 422752 from Patent EP1572962.
AY540753 - Homo sapiens rhabdomyosarcoma antigen MU-RMS-40.23 (RAD52) mRNA, complete cds.
JD363125 - Sequence 344149 from Patent EP1572962.
JD046149 - Sequence 27173 from Patent EP1572962.
JD372371 - Sequence 353395 from Patent EP1572962.
JD288239 - Sequence 269263 from Patent EP1572962.
JD557107 - Sequence 538131 from Patent EP1572962.
JD454242 - Sequence 435266 from Patent EP1572962.
JD052003 - Sequence 33027 from Patent EP1572962.
JD267448 - Sequence 248472 from Patent EP1572962.
JD510925 - Sequence 491949 from Patent EP1572962.
BC160123 - Synthetic construct Homo sapiens clone IMAGE:100064155, MGC:193238 RAD52 homolog (S. cerevisiae) (RAD52) mRNA, encodes complete protein.
AB528581 - Synthetic construct DNA, clone: pF1KB0498, Homo sapiens RAD52 gene for RAD52 homolog, without stop codon, in Flexi system.
JD276870 - Sequence 257894 from Patent EP1572962.
JD203932 - Sequence 184956 from Patent EP1572962.
JD195461 - Sequence 176485 from Patent EP1572962.
JD492586 - Sequence 473610 from Patent EP1572962.
JD309660 - Sequence 290684 from Patent EP1572962.
JD068975 - Sequence 49999 from Patent EP1572962.
JD394808 - Sequence 375832 from Patent EP1572962.
JD463687 - Sequence 444711 from Patent EP1572962.
JD128975 - Sequence 109999 from Patent EP1572962.
JD050970 - Sequence 31994 from Patent EP1572962.
JD355565 - Sequence 336589 from Patent EP1572962.
AF125950 - Homo sapiens DNA repair protein RAD52 beta isoform (RAD52) mRNA, alternatively spliced, complete cds.
JD560068 - Sequence 541092 from Patent EP1572962.
JD182899 - Sequence 163923 from Patent EP1572962.
JD077853 - Sequence 58877 from Patent EP1572962.
JD378908 - Sequence 359932 from Patent EP1572962.
JD450438 - Sequence 431462 from Patent EP1572962.
CQ873742 - Sequence 161 from Patent WO2004076622.
DD413579 - Regulation of Mammalian Cells.
JD251509 - Sequence 232533 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000358495.1, ENST00000358495.2, ENST00000358495.3, ENST00000358495.4, ENST00000358495.5, ENST00000358495.6, ENST00000358495.7, hCG_25272 , NM_134424, Q5DR82, Q5DR82_HUMAN, RAD52 , uc318aow.1, uc318aow.2
UCSC ID: ENST00000358495.8_11
RefSeq Accession: NM_134424.4
Protein: Q5DR82

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.