ID:RALB_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Ral-B; Flags: Precursor; FUNCTION: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). SUBUNIT: Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=During late cytokinesis localizes at the midbody. PTM: Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs). SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11234
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001928 regulation of exocyst assembly GO:0001934 positive regulation of protein phosphorylation GO:0006915 apoptotic process GO:0007049 cell cycle GO:0007165 signal transduction GO:0007265 Ras protein signal transduction GO:0009267 cellular response to starvation GO:0032091 negative regulation of protein binding GO:0032092 positive regulation of protein binding GO:0051301 cell division GO:0060178 regulation of exocyst localization GO:0071360 cellular response to exogenous dsRNA GO:0071902 positive regulation of protein serine/threonine kinase activity GO:2000786 positive regulation of autophagosome assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
