ID:RBP2_HUMAN DESCRIPTION: RecName: Full=E3 SUMO-protein ligase RanBP2; EC=6.3.2.-; AltName: Full=358 kDa nucleoporin; AltName: Full=Nuclear pore complex protein Nup358; AltName: Full=Nucleoporin Nup358; AltName: Full=Ran-binding protein 2; Short=RanBP2; AltName: Full=p270; Includes: RecName: Full=Putative peptidyl-prolyl cis-trans isomerase; Short=PPIase; EC=5.2.1.8; AltName: Full=Rotamase; FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). PATHWAY: Protein modification; protein sumoylation. SUBUNIT: Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 but not SUMO2. Interacts with PARK2. Interacts with sumoylated RANGAP1. Interacts with CDCA8. INTERACTION: P04626:ERBB2; NbExp=3; IntAct=EBI-973138, EBI-641062; O60260:PARK2; NbExp=11; IntAct=EBI-973138, EBI-716346; Q53GG5:PDLIM3; NbExp=3; IntAct=EBI-973138, EBI-5658852; SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Note=Cytoplasmic filaments. DOMAIN: Contains F-X-F-G repeats. PTM: Polyubiquitinated by PARK2, which leads to proteasomal degradation. DISEASE: Defects in RANBP2 are the cause of encephalopathy acute infection-induced type 3 (IIAE3) [MIM:608033]. A rapidly progressive encephalopathy manifesting in susceptibile individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. Note=Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815). SIMILARITY: Contains 1 PPIase cyclophilin-type domain. SIMILARITY: Contains 4 RanBD1 domains. SIMILARITY: Contains 8 RanBP2-type zinc fingers. SIMILARITY: Contains 1 TPR repeat. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RANBP2ID483.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49792
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0000413 protein peptidyl-prolyl isomerization GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006457 protein folding GO:0006511 ubiquitin-dependent protein catabolic process GO:0006607 NLS-bearing protein import into nucleus GO:0007051 spindle organization GO:0015031 protein transport GO:0016032 viral process GO:0016925 protein sumoylation GO:0043547 positive regulation of GTPase activity GO:0046604 positive regulation of mitotic centrosome separation GO:0046907 intracellular transport GO:0051028 mRNA transport GO:0051642 centrosome localization
D42063 - Homo sapiens mRNA for RanBP2 (Ran-binding protein 2), complete cds. LP895392 - Sequence 256 from Patent EP3253886. JD247658 - Sequence 228682 from Patent EP1572962. JD490303 - Sequence 471327 from Patent EP1572962. AB209483 - Homo sapiens mRNA for RAN binding protein 2 variant protein. DQ578622 - Homo sapiens piRNA piR-46734, complete sequence. JD168593 - Sequence 149617 from Patent EP1572962. AK026993 - Homo sapiens cDNA: FLJ23340 fis, clone HEP13465, highly similar to HUMRANBP2 Human mRNA for RanBP2. U19240 - Human Ran binding protein mRNA, partial cds. AK025711 - Homo sapiens cDNA: FLJ22058 fis, clone HEP10089, highly similar to HUMRANBP2 Human mRNA for RanBP2 (Ran-binding protein 2). U19248 - Human Ran binding protein mRNA, partial cds. AY170822 - Homo sapiens transformation-related protein 1 mRNA, complete cds. JD023731 - Sequence 4755 from Patent EP1572962. AY170823 - Homo sapiens transformation-related protein 2 mRNA, complete cds. AK025462 - Homo sapiens cDNA: FLJ21809 fis, clone HEP00942, highly similar to HUMRANBP2 Human mRNA for RanBP2 (Ran-binding protein 2). JD555229 - Sequence 536253 from Patent EP1572962. JD284030 - Sequence 265054 from Patent EP1572962. JD509460 - Sequence 490484 from Patent EP1572962. JD285158 - Sequence 266182 from Patent EP1572962. JD548185 - Sequence 529209 from Patent EP1572962. JD411633 - Sequence 392657 from Patent EP1572962. JD299460 - Sequence 280484 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_npcPathway - Mechanism of Protein Import into the Nucleus h_ranbp2Pathway - Sumoylation by RanBP2 Regulates Transcriptional Repression h_ranPathway - Cycling of Ran in nucleocytoplasmic transport
Reactome (by CSHL, EBI, and GO)
Protein P49792 (Reactome details) participates in the following event(s):
R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC R-HSA-180622 Vpr binds nucleoporins R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore R-HSA-2990882 CDK1 phosphorylates NUP98 R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98 R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2 R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1 R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2 R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1 R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3 R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1 R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1 R-HSA-192627 Viral mRNA Export R-HSA-192925 Export of Spliced Viral mRNA R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-180746 Nuclear import of Rev protein R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-177243 Interactions of Rev with host cellular proteins R-HSA-176033 Interactions of Vpr with host cellular proteins R-HSA-2980766 Nuclear Envelope Breakdown R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-1169408 ISG15 antiviral mechanism R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-6784531 tRNA processing in the nucleus R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-162587 HIV Life Cycle R-HSA-162909 Host Interactions of HIV factors R-HSA-68875 Mitotic Prophase R-HSA-70171 Glycolysis R-HSA-168253 Host Interactions with Influenza Factors R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-211000 Gene Silencing by RNA R-HSA-72306 tRNA processing R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-3371556 Cellular response to heat stress R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-8953854 Metabolism of RNA R-HSA-162906 HIV Infection R-HSA-70326 Glucose metabolism R-HSA-168254 Influenza Infection R-HSA-913531 Interferon Signaling R-HSA-74160 Gene expression (Transcription) R-HSA-2990846 SUMOylation R-HSA-168255 Influenza Life Cycle R-HSA-2262752 Cellular responses to stress R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-5663205 Infectious disease R-HSA-71387 Metabolism of carbohydrates R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-597592 Post-translational protein modification R-HSA-8953897 Cellular responses to external stimuli R-HSA-1643685 Disease R-HSA-1430728 Metabolism R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
