Human Gene RAPGEF2 (ENST00000691494.1_5) from GENCODE V47lift37
  Description: Rap guanine nucleotide exchange factor 2, transcript variant 7 (from RefSeq NM_001394067.2)
Gencode Transcript: ENST00000691494.1_5
Gencode Gene: ENSG00000109756.10_18
Transcript (Including UTRs)
   Position: hg19 chr4:160,024,231-160,281,325 Size: 257,095 Total Exon Count: 30 Strand: +
Coding Region
   Position: hg19 chr4:160,025,315-160,279,291 Size: 253,977 Coding Exon Count: 30 

Page IndexSequence and LinksPrimersCTDGene AllelesMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:160,024,231-160,281,325)mRNA (may differ from genome)Protein (1660 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -624.001084-0.576 Picture PostScript Text
3' UTR -564.402034-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LP896321 - Sequence 1185 from Patent EP3253886.
JD407351 - Sequence 388375 from Patent EP1572962.
JD191249 - Sequence 172273 from Patent EP1572962.
JD191250 - Sequence 172274 from Patent EP1572962.
JD389916 - Sequence 370940 from Patent EP1572962.
AK294459 - Homo sapiens cDNA FLJ61094 partial cds, highly similar to Rap guanine nucleotide exchange factor 2.
AB002311 - Homo sapiens mRNA for KIAA0313 gene.
LP895493 - Sequence 357 from Patent EP3253886.
AB383844 - Synthetic construct DNA, clone: pF1KSDA0313, Homo sapiens RAPGEF2 gene for Rap guanine nucleotide exchange factor 2, complete cds, without stop codon, in Flexi system.
BC117321 - Homo sapiens Rap guanine nucleotide exchange factor (GEF) 2, mRNA (cDNA clone MGC:150930 IMAGE:40125872), complete cds.
AL117397 - Homo sapiens mRNA; cDNA DKFZp586O1422 (from clone DKFZp586O1422).
LF325672 - JP 2014500723-A/133175: Polycomb-Associated Non-Coding RNAs.
JD482887 - Sequence 463911 from Patent EP1572962.
JD439261 - Sequence 420285 from Patent EP1572962.
JD320154 - Sequence 301178 from Patent EP1572962.
JD356162 - Sequence 337186 from Patent EP1572962.
JD544224 - Sequence 525248 from Patent EP1572962.
JD218671 - Sequence 199695 from Patent EP1572962.
JD042490 - Sequence 23514 from Patent EP1572962.
JD415447 - Sequence 396471 from Patent EP1572962.
BC110355 - Homo sapiens cDNA clone IMAGE:5248072.
AF070570 - Homo sapiens clone 24473 mRNA sequence.
JD526871 - Sequence 507895 from Patent EP1572962.
JD507861 - Sequence 488885 from Patent EP1572962.
JD512192 - Sequence 493216 from Patent EP1572962.
JD085655 - Sequence 66679 from Patent EP1572962.
JD320668 - Sequence 301692 from Patent EP1572962.
JD295856 - Sequence 276880 from Patent EP1572962.
JD213961 - Sequence 194985 from Patent EP1572962.
JD554683 - Sequence 535707 from Patent EP1572962.
JD271787 - Sequence 252811 from Patent EP1572962.
JD531706 - Sequence 512730 from Patent EP1572962.
JD093525 - Sequence 74549 from Patent EP1572962.
JD375535 - Sequence 356559 from Patent EP1572962.
JD410964 - Sequence 391988 from Patent EP1572962.
JD566552 - Sequence 547576 from Patent EP1572962.
JD553410 - Sequence 534434 from Patent EP1572962.
JD516046 - Sequence 497070 from Patent EP1572962.
MA561249 - JP 2018138019-A/133175: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A8I5KZ40, A0A8I5KZ40_HUMAN, NM_001394067, RAPGEF2 , uc330wbe.1, uc330wbe.2
UCSC ID: ENST00000691494.1_5
RefSeq Accession: NM_001394067.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.