ID:RARB_HUMAN DESCRIPTION: RecName: Full=Retinoic acid receptor beta; Short=RAR-beta; AltName: Full=HBV-activated protein; AltName: Full=Nuclear receptor subfamily 1 group B member 2; AltName: Full=RAR-epsilon; FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. SUBUNIT: Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts weakly with NCOR2. SUBCELLULAR LOCATION: Isoform Beta-1: Nucleus. SUBCELLULAR LOCATION: Isoform Beta-2: Nucleus. SUBCELLULAR LOCATION: Isoform Beta-4: Cytoplasm. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. SEQUENCE CAUTION: Sequence=CAA27637.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10826
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0003708 retinoic acid receptor activity GO:0005515 protein binding GO:0008144 drug binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0044877 macromolecular complex binding GO:0046872 metal ion binding GO:0046965 retinoid X receptor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001657 ureteric bud development GO:0002068 glandular epithelial cell development GO:0003148 outflow tract septum morphogenesis GO:0003406 retinal pigment epithelium development GO:0003417 growth plate cartilage development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007165 signal transduction GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0021756 striatum development GO:0022008 neurogenesis GO:0031641 regulation of myelination GO:0032331 negative regulation of chondrocyte differentiation GO:0035116 embryonic hindlimb morphogenesis GO:0035264 multicellular organism growth GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043068 positive regulation of programmed cell death GO:0043401 steroid hormone mediated signaling pathway GO:0045666 positive regulation of neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048048 embryonic eye morphogenesis GO:0048384 retinoic acid receptor signaling pathway GO:0048566 embryonic digestive tract development GO:0055012 ventricular cardiac muscle cell differentiation GO:0060041 retina development in camera-type eye GO:0060348 bone development GO:0061037 negative regulation of cartilage development
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
